Results 111 to 120 of about 430,684 (299)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Covering 40–50% of world’s arable lands, acidic soils pose a major constraint on global crop productivity by severely restricting root development and nutrient acquisition.
Jia Yuan Ye +11 more
doaj +1 more source
Phosphogypsum (PG) is a bulk solid waste characterized by high acidity and toxic elements, causing environmental pollution risks. This study proposes a targeted solidification/stabilization (S/S) method using quicklime as an alkaline regulator and ...
Yiting Wang +4 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
The degree of commitment to regulator independence: measurement and impact [PDF]
This study computes measures of the degree of independence in practice of telecommunications regulators for Latin American and Caribbean countries in a new data set for 23 countries between 1990 and 2004.
Miguel Angel Montoya, Francesc Trillas
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Abscisic acid (ABA) is a core regulator in plant growth and development, yet its roles in fruit ripening and quality formation remains poorly characterized in passion fruit.
Jinglei Xu +5 more
doaj +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Poster promoting a concert featuring the punk and indie rock bands Regulator Watts, Ethel Meserve, Hurl, and Cole.
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