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GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
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Regulation of mTOR by phosphatidic acid
Trends in Endocrinology & Metabolism, 2023mTORC1, the mammalian target of rapamycin complex 1, is a key regulator of cellular physiology. The lipid metabolite phosphatidic acid (PA) binds to and activates mTORC1 in response to nutrients and growth factors. We review structural findings and propose a model for PA activation of mTORC1.
Maria A. Frias +2 more
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Regulation of Bile Acid Biosynthesis
Current Pharmaceutical Design, 1997Abstract: An elevated concentration of low density lipoprotein (LDL) cholesterol is an independent risk factor for cardiovascular disease. The only quantitatively significant way by which cholesterol is removed from the body is via the bile, either directly or after conversion to bile acids. Therapeutic modalities which increase bile acid biosynthesis,
Princen, H.M.G., Post, S.M., Twisk, J.
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Regulation of bile acid synthesis
Hepatology, 1991HEPATIC CHOLESTEROL HOMEOSTASIS The liver plays a central role in the regulation of cholesterol homeostasis. Under normal conditions, cholesterol input into the body equals output; cholesterol homeostasis is maintained. Under pathologic conditions, enhancement of cholesterol input into the liver or a reduction in hepatic cholesterol output may ...
Z R, Vlahcevic +2 more
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REGULATION OF BILE ACID BIOSYNTHESIS
Gastroenterology Clinics of North America, 1999This article provides a review of the pathways through which cholesterol is degraded to bile acids. Regulation of key enzymes in the bile acid biosynthestic pathways is discussed. The important role of these pathways in the maintenance of cholesterol homeostasis and the possible therapeutic implications for the treatment of hypercholesterolemia are ...
Z R, Vlahcevic +2 more
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Regulation of Gastric Acid Secretion
Current Opinion in Gastroenterology, 1998This paper summarizes important developments, published over the past year, that improve our understanding of the regulation of gastric acid secretion at the central, peripheral, and intracellular levels and mechanisms by which various neurotransmitters, paracrine agents, and hormones regulate gastric secretion and are themselves regulated.
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Acid-base regulation by the kidneys
The American Journal of Medicine, 1950Abstract The kidney participates in the regulation of body neutrality by stabilizing the plasma concentration of bicarbonate-bound base at a level of 25 to 27 mEq. /L. The respiratory system participates by stabilizing the plasma carbonic acid level at 1.25 to 1.35 mEq. /L.
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REGULATION OF FATTY ACID SYNTHESIS
Annual Review of Plant Physiology and Plant Molecular Biology, 1997▪ Abstract All plant cells produce fatty acids from acetyl-CoA by a common pathway localized in plastids. Although the biochemistry of this pathway is now well understood, much less is known about how plants control the very different amounts and types of lipids produced in different tissues.
John B., Ohlrogge, Jan G., Jaworski
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Regulation of Gastric Acid Secretion
Annual Review of Physiology, 1979The three stimulants of gastric acid secretion likely to have physiological roles in regulation of secretion are acetylcholine, gastrin, and histamine. Acetylcholine is released by vagal and intramucosal reflex stimulation, acting directly on the parietal cell.
A H, Soll, J H, Walsh
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Acid-base regulation in pregnancy
American Journal of Physiology-Legacy Content, 1976Plasma bicarbonate decreases during normal pregnancy. To assess what roles increased extra cellular volume or alterations in parathyroid hormone levels (iPTH) have in the maintenance of this decrement, we evaluated acid-base metabolism in eleven 3rd-trimester women. Base-line pH and PCO2 were 7.44 and 27.3 mmHg, respectively. Mean tubular reabsorption
V S, Lim, A I, Katz, M D, Lindheimer
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