Results 231 to 240 of about 9,968 (290)

Phosphatidylcholine coordinates ER-autonomous and ER-nonautonomous adaptations to unfolded protein response dysfunction. [PDF]

J Biol Chem
Tong H, Li W, Yuan P, Wang X, Pang S, Tang H.   +5 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Maintenance and Decline of Neuronal Lysosomal Function in Aging. [PDF]

Cells
Zhong R, Richardson CE.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Topographic modulation of soil functional indicators in shaded coffee agroforestry systems: a multivariate and network-based approach. [PDF]

Sci Rep
Crespo CMG, Piscoya VC, de Melo RCP, Pereira LM, Santos LDV, Holanda FSR, Pedrotti A, da Silva SAB, Filho MC, de Araújo Filho RN.   +9 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in <i>C. elegans</i>. [PDF]

Sci Adv
Zhai Y, Wang T, Han J, Wu M, Gong M, Li W, Zhang Z.   +6 more
europepmc   +1 more source

Reactive nitrogen-driven atmospheric multiphase buffering induces unintended concomitant pollution. [PDF]

Nat Commun
Wei Y, Gao J, Wang H, Xu H, Feng Y, Shi G, Shi G, Song S, Russell AG.   +8 more
europepmc   +1 more source

AI-Assisted Detection of Early Gastric Cancer via Visualization of Mucosal Acidity Compromise During Endoscopy. [PDF]

Adv Sci (Weinh)
Yan H, Li Z, Zhao J, Su L, Jin Z, Zhao W, Duan R, Zhou S, Wang L, Mao J, Lu X, Gai W, Du Y, Du Q, Fang C, Zhao Y, You Y, Cai J, Li C.   +18 more
europepmc   +1 more source