Results 11 to 20 of about 65,295 (252)
Dexamethasone associated with lactic acidosis in a stroke patient with meningioma-associated vasogenic edema: a case report [PDF]
Journal of Medical Case ReportsBackground Corticosteroids are commonly used to manage a multitude of conditions, ranging from autoimmune to neurological diseases, including central nervous system vasculitis and vasogenic edema from large strokes.
Joon Sin Ser, Tze Chao Wee
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New England Journal of Medicine, 2014 Lactic acidosis results from the accumulation of lactate and protons in the body fluids and is often associated with poor clinical outcomes. The effect of lactic acidosis is governed by its severity and the clinical context. Mortality is increased by a factor of nearly three when lactic acidosis accompanies low-flow states or sepsis,1 and the higher ...
Ingelfinger, Julie R +2 more
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Metformin-Associated Lactic Acidosis [PDF]
Endocrinology and Metabolism, 2015 Introduction Metformin is a first line oral medication for diabetes mellitus shown to decrease cardiovascular morbidity and mortality. Though the prevalence of metformin-associated lactic acidosis (MALA) is low, mortality is high, ranging from 25-50 ...
Sunghwan Suh
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Saudi Pharmaceutical Journal, 2022 Linezolid is an oxazolidinone antibiotic. Linezolid-associated lactic acidosis has been reported in 6.8% of linezolid-treated patients. Lactic acidosis is associated with poor clinical outcomes, with high blood lactate levels resulting in organ ...
Naiju Zhang +5 more
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The genomic analysis of lactic acidosis and acidosis response in human cancers. [PDF]
PLoS Genetics, 2008 The tumor microenvironment has a significant impact on tumor development. Two important determinants in this environment are hypoxia and lactic acidosis.
Julia Ling-Yu Chen +8 more
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Kidney International, 1986 Lactic acidosis is a metabolic disturbance characterized by an increase of the production/clearance ratio of lactate. Lactate is a catabolite of glycolysis when this takes place under anaerobic conditions. Clinically LA is characterized by: signs of acidosis, venous blood lactate greater than 5 mMol/l, arterial pH less than 7.25.
MOLINATTI GM +3 more
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Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. [PDF]
PLoS Genetics, 2010 Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional responses of breast cancer
Julia Ling-Yu Chen +9 more
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Type B Lactic Acidosis in A Child with Relapsed non-Hodgkin Lymphoma
Journal of Pediatric Emergency and Intensive Care Medicine, 2023 Lactic acidosis is a major cause of metabolic acidosis in critically ill patients. Herein we report a child with relapsed non-Hodgkin’s lymphoma admitted to the pediatric intensive care unit (PICU) with profound lactic acidosis.
Tolga Besci +5 more
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Scientific Reports, 2020 Extracellular acidosis is considered as a hallmark of most human tumors, which plays an important role in promoting tumor malignant and aggressive phenotype in tumorigenesis. Acidosis and lactic acidosis can induce different responses in tumors. Previous
Jiayue Gao +8 more
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Severe drug-induced liver injury associated with prolonged use of Linezolid [PDF]
, 2010 This study aims to describe a patient developing concomitant severe liver failure and lactic acidosis after long-term treatment with linezolid. A 55-year-old Caucasian woman developed concomitant severe liver failure and lactic acidosis after a treatment
Benoit, Dominique +7 more
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