Results 11 to 20 of about 38,696 (225)

Mechanistic Population Pharmacokinetic Modeling of Extended-Release Metformin in Obese South African Women Living with HIV on Dolutegravir. [PDF]

open access: yesClin Pharmacol Ther
Regulatory limits on metformin co‐administered with dolutegravir (DTG) derive from healthy‐volunteer studies in which DTG increased metformin exposure by 79% through organic cation transporter 2 inhibition, prompting a 1,000 mg/day metformin dose restriction.
Benecke RM   +3 more
europepmc   +2 more sources

A patient with metformin-associated lactic acidosis successfully treated with continuous renal replacement therapy: a case report

open access: yesJournal of Medical Case Reports, 2019
Background Metformin has been widely used as a first-line agent to treat type 2 diabetes mellitus. Lactic acidosis is a rare but serious adverse effect in patients treated with metformin.
Hiroki Kinoshita   +4 more
doaj   +1 more source

Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature

open access: yesCase Reports in Medicine, 2009
Lactic acidosis is commonly observed in clinical situations such as shock and sepsis, as a result of tissue hypoperfusion and hypoxia. Lymphoma and leukemia are among other clinical situations where lactic acidosis has been reported. We present a case of
Farn Huei Chan   +2 more
doaj   +1 more source

Type B lactic acidosis associated with diffuse large B-cell lymphoma and the Warburg effect

open access: yesJournal of International Medical Research, 2022
Type B lactic acidosis is a rare complication of non-tissue perfusion abnormalities caused by solid tumors or hematologic malignancies. Herein, we present the case of a 42-year-old man with type B lactic acidosis and hypoglycemia who was found to have a ...
Chunhua Wang, Zanmei Lv, Yanwei Zhang
doaj   +1 more source

Chronic Skull Base Erosion from Temporomandibular Joint Disease Causes Generalized Seizure and Profound Lactic Acidosis

open access: yesCase Reports in Critical Care, 2018
This report displays a rare presentation of lactic acidosis in the setting of status epilepticus (SE). The differential diagnosis of lactic acidosis is broad and typically originates from states of shock; however, this report highlights an alternative ...
Mark A. Dobish   +7 more
doaj   +1 more source

Lactic acidosis occurrence during exercises in the smoke chamber in a 53-year-old firefighter with no significant medical history

open access: yesInternational Journal of Occupational Medicine and Environmental Health, 2014
Lactic acidosis is a form of metabolic acidosis with a high anion gap, reduced rate of arterial blood pH under 7.35 mmol/l, and lactic acid concentration over 7 mmol/l.
Agata Bronisz   +2 more
doaj   +1 more source

Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case report

open access: yesJournal of Medical Case Reports, 2023
Background Type B lactic acidosis is a rare but serious side effect of metformin use. The risk of metformin-associated lactic acidosis is elevated in renal or liver impairment, heart failure and in metformin overdose. Metformin-associated lactic acidosis
Diana Yusim   +5 more
doaj   +1 more source

Metformin Intoxication, Lactic Acidosis and Death: Case Report

open access: yesJournal of Basic and Applied Research in Biomedicine, 2022
Metformin is an oral antidiabetic agent used as  in the treatment of T2DM. A fearsome complication of the use of metformin is lactic acidosis. A nineteen-year-old woman was unconscious and cyanotic in her home.
Zafer Pekkolay   +4 more
doaj  

A Rare Case of Severe Lactic Acidosis in a Patient With Mantle Cell Lymphoma

open access: yesJournal of Investigative Medicine High Impact Case Reports, 2021
Lactic acidosis is an extremely rare paraneoplastic manifestation of hematological malignancies, and often carries an extremely poor prognosis. Mantle cell lymphoma is an aggressive and rare form of non-Hodgkin lymphoma.
Kok Hoe Chan MD   +5 more
doaj   +1 more source

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