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Lactic acidosis is a form of metabolic acidosis with a high anion gap, reduced rate of arterial blood pH under 7.35 mmol/l, and lactic acid concentration over 7 mmol/l.
Agata Bronisz +2 more
doaj +1 more source
Background Type B lactic acidosis is a rare but serious side effect of metformin use. The risk of metformin-associated lactic acidosis is elevated in renal or liver impairment, heart failure and in metformin overdose. Metformin-associated lactic acidosis
Diana Yusim +5 more
doaj +1 more source
Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis. [PDF]
Debate exists regarding the safety of metformin and the risk of metformin-associated lactic acidosis, particularly in the setting of kidney dysfunction.
Kalantar-Zadeh, Kamyar, Rhee, Connie M
core +1 more source
A novel mutation in NDUFB11 unveils a new clinical phenotype associated with lactic acidosis and sideroblastic anemia [PDF]
NDUFB11, a component of mitochondrial complex I, is a relatively small integral membrane protein, belonging to the 'supernumerary' group of subunits, but proved to be absolutely essential for the assembly of an active complex I.
Bertini, Enrico +21 more
core +2 more sources
Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis [PDF]
Introduction:\ud \ud Acute metabolic acidosis of non-renal origin is usually a result of either lactic or ketoacidosis, both of which are associated with a high anion gap. There is increasing recognition, however, of a group of acidotic patients who have
Forni, L.G. +5 more
core +2 more sources
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/32231/1/0000292 ...
openaire +4 more sources
Metformin Intoxication, Lactic Acidosis and Death: Case Report
Metformin is an oral antidiabetic agent used as in the treatment of T2DM. A fearsome complication of the use of metformin is lactic acidosis. A nineteen-year-old woman was unconscious and cyanotic in her home.
Zafer Pekkolay +4 more
doaj
Seizure Disorders in Goats and Sheep. [PDF]
BackgroundGoats and sheep are more likely to be presented for examination for seizures than are cattle, possibly as a consequence of their relatively smaller body size.
Aleman, M, Chigerwe, M
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A Rare Case of Severe Lactic Acidosis in a Patient With Mantle Cell Lymphoma
Lactic acidosis is an extremely rare paraneoplastic manifestation of hematological malignancies, and often carries an extremely poor prognosis. Mantle cell lymphoma is an aggressive and rare form of non-Hodgkin lymphoma.
Kok Hoe Chan MD +5 more
doaj +1 more source
Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]
BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach +18 more
core +4 more sources

