Results 21 to 30 of about 38,696 (225)

Recurrent lactic acidosis and hypoglycemia with inadvertent metformin use: a case of look-alike pills

Endocrinology, Diabetes & Metabolism Case Reports, 2018
Metformin is recommended as the first-line agent for the treatment of type 2 diabetes. Although this drug has a generally good safety profile, rare but potentially serious adverse effects may occur.
Tess Jacob, Renee Garrick, Michael D Goldberg   +2 more
doaj   +1 more source

Severe Metabolic Acidemia in a Patient with Aleukemic Leukemia

Case Reports in Nephrology, 2018
Malignancy associated lactic acidosis is a rare metabolic complication that may accompany various types of malignancies. To date, most cases that have been reported are associated with hematologic malignancies (lymphoma and leukemia).
Moutaz Ghrewati, Faiza Manji, Varun Modi, Chandra Chandran, Michael Maroules   +4 more
doaj   +1 more source

Hemodialysis for lactic acidosis

Indian Journal of Critical Care Medicine, 2017
Lactic acidosis (Type A) is common in critically ill patients and usually treated by correcting the underlying etiology. We present the case of a young female who presented with life-threatening lactic acidosis secondary to hematological malignancy. Timely initiation of hemodialysis was lifesaving. The case highlights the importance of considering Type
Karthiraj, N., Ramakrishnan, Nagarajan, Mani, Ashwin K.   +2 more
openaire   +2 more sources

Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study.

PLoS ONE, 2018
BackgroundMetformin constitutes first-line treatment of type 2 diabetes mellitus. It is presumed to have lactic acidosis as a dangerous, but rare, side effect.ObjectivesTo estimate the incidence rate of lactic acidosis in patients with type 2 diabetes ...
Abdellatif Aharaz, Anton Pottegård, Daniel Pilsgaard Henriksen, Jesper Hallas, Henning Beck-Nielsen, Annmarie Touborg Lassen   +5 more
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Lactic Acidosis in Diabetes [PDF]

BMJ, 1969
Lactic acidosis is occasionally responsible for metabolic acidosis in diabetics. It may occur in the presence of normal blood levels of the ketone bodies, and such cases are often described as having “non-ketotic diabetic acidosis.” Lactic acid may contribute to the metabolic acidosis in patients with true diabetic ketoacidosis, but the blood lactate ...
P J, Watkins, J S, Smith, M G, Fitzgerald, J M, Malins   +3 more
openaire   +2 more sources

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source

Dexamethasone associated with lactic acidosis in a stroke patient with meningioma-associated vasogenic edema: a case report

Journal of Medical Case Reports
Background Corticosteroids are commonly used to manage a multitude of conditions, ranging from autoimmune to neurological diseases, including central nervous system vasculitis and vasogenic edema from large strokes.
Joon Sin Ser, Tze Chao Wee
doaj   +1 more source

Warburg′s effect on solid tumors

Saudi Journal of Kidney Diseases and Transplantation, 2014
Lactic acidosis is the result of imbalance between the systemic formation of lactate and its hepatic metabolism. In cancer patients, lactic acidosis is mainly associated with hematologic malignancies (leukemia and lymphomas) and the mechanism is known as
Talal El Imad, Lara El Khoury, Abdallah Sassine Geara   +2 more
doaj   +1 more source

pH‐Responsive Synthetic Cells for Programmable In Situ Protein Synthesis and Release

Advanced Materials, EarlyView.
A synthetic cell is engineered to convert environmental acidification into nucleic acid signaling that activates protein synthesis. By coupling proton‐channel sensing, pH‐responsive DNA transduction, and toehold‐regulated translation, the platform enables acid‐triggered protein production within hydrogel‐embedded synthetic cells.
Sung‐Won Hwang, Yudan Li, Alexander A. Green, Allen P. Liu   +3 more
wiley   +1 more source