Results 11 to 20 of about 143,662 (295)

Ammonium chloride administration prior to exercise has muscle‐specific effects on mitochondrial and myofibrillar protein synthesis in rats

Physiological Reports, 2021
Aim Exercise is able to increase both muscle protein synthesis and mitochondrial biogenesis. However, acidosis, which can occur in pathological states as well as during high‐intensity exercise, can decrease mitochondrial function, whilst its impact on ...
Amanda J. Genders, Evelyn C. Marin, Joseph J. Bass, Jujiao Kuang, Nicholas J. Saner, Ken Smith, Philip J. Atherton, David J. Bishop   +7 more
doaj   +1 more source

Lactic Acidosis [PDF]

New England Journal of Medicine, 2014
Lactic acidosis results from the accumulation of lactate and protons in the body fluids and is often associated with poor clinical outcomes. The effect of lactic acidosis is governed by its severity and the clinical context. Mortality is increased by a factor of nearly three when lactic acidosis accompanies low-flow states or sepsis,1 and the higher ...
Ingelfinger, Julie R, Kraut, Jeffrey A, Madias, Nicolaos E   +2 more
openaire   +9 more sources

Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans

Physiological Reports, 2021
Ischemic skeletal muscle conditions are known to augment exercise‐induced increases in blood pressure (BP). Aging is also a factor that enhances the pressor response to exercise.
Daisuke Hasegawa, Amane Hori, Yukiko Okamura, Reizo Baba, Kenichi Suijo, Masaki Mizuno, Jun Sugawara, Koji Kitatsuji, Hisayoshi Ogata, Kaoru Toda, Norio Hotta   +10 more
doaj   +1 more source

Impact of SARS-CoV-2 Infection on Unvaccinated Pregnant Women: Non-Reassuring Fetal Heart Rate Tracing Because of Placentitis

Viruses, 2023
In 2020, a new coronavirus, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. SARS-CoV-2 infection has been shown to be highly morbid in pregnant women, being a risk factor for several obstetric conditions leading to ...
Alexandra Claudet, Daniele De Luca, Elie Mosnino, Jérémie Mattern, Olivier Picone, Jeanne Sibiude, Estelle Wafo, Vassilis Tsatsaris, Emilie Giral, Irène Grefenstette, Julie Carrara, Dominique A. Badr, Marie-Hélène Saint-Frison, Sophie Prevot, Alexandra Benachi, Alexandre J. Vivanti   +15 more
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Optimal Parameters for Return of Spontaneous Circulation in Resuscitating Out-of-hospital Cardiac Arrest Patients

International Journal of Gerontology, 2009
Background: To study the parameters of out-of-hospital cardiac arrest (OHCA) patients to improve the return of spontaneous circulation (ROSC) rate during resuscitation.
Yu-Jang Su, Yen-Chun Lai
doaj   +1 more source

Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective study

Journal of Clinical Sciences, 2020
Background: Estimation of the serum pH and base excess as determinants of the adequacy of resuscitation may predict the patient outcome in peritonitis. Materials, Patients and Methods: This was a prospective study conducted in University College Hospital,
O Oludolapo Afuwape, Omobolaji Ayandipo, Samuel Aroso   +2 more
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HMG-CoA Lyase Deficiency: A Retrospective Study of 62 Saudi Patients

Frontiers in Genetics, 2022
3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency (HMG-CoA lyase) is a rare inborn error of leucine degradation and ketone body synthesis, caused by homozygous or compound heterozygous disease-causing variants in HMGCL.
Majid Alfadhel, Majid Alfadhel, Basma Abadel, Hind Almaghthawi, Muhammad Umair, Zuhair Rahbeeni, Eissa Faqeih, Mohammed Almannai, Ali Alasmari, Mohammed Saleh, Wafaa Eyaid, Wafaa Eyaid, Ahmed Alfares, Ahmed Alfares, Fuad Al Mutairi, Fuad Al Mutairi   +15 more
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EEG Discontinuity and Neonatal Acidosis

Pediatric Neurology Briefs, 1994
The effect of acidosis on cerebral function was evaluated by computerized online EEG monitoring in 14 ventilated preterm infants less than 32 weeks’ gestation at the Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School ...
J Gordon Millichap
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CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH

Cell Reports, 2022
Summary: Unlike most cell types, many cancer cells survive at low extracellular pH (pHe), a chemical signature of tumors. Genes that facilitate survival under acid stress are therefore potential targets for cancer therapies.
Johanna Michl, Yunyi Wang, Stefania Monterisi, Wiktoria Blaszczak, Ryan Beveridge, Esther M. Bridges, Jana Koth, Walter F. Bodmer, Pawel Swietach   +8 more
doaj   +1 more source

L-DOS47 Elevates Pancreatic Cancer Tumor pH and Enhances Response to Immunotherapy

Biomedicines
Acidosis is an important immunosuppressive mechanism that leads to tumor growth. Therefore, we investigated the neutralization of tumor acidity to improve immunotherapy response. L-DOS47, a new targeted urease immunoconjugate designed to neutralize tumor
Bruna Victorasso Jardim-Perassi, Pietro Irrera, Oluwaseyi E. Oluwatola, Dominique Abrahams, Veronica C. Estrella, Bryce Ordway, Samantha R. Byrne, Andrew A. Ojeda, Christopher J. Whelan, Jongphil Kim, Matthew S. Beatty, Sultan Damgaci-Erturk, Dario Livio Longo, Kim J. Gaspar, Gabrielle M. Siegers, Barbara A. Centeno, Justin Y. C. Lau, Shari A. Pilon-Thomas, Arig Ibrahim-Hashim, Robert J. Gillies   +19 more
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