Acidosis Is a Key Regulator of Osteoblast Ecto-Nucleotidase Pyrophosphatase/Phosphodiesterase 1 (NPP1) Expression and Activity [PDF]
, 2015 Previous work has shown that acidosis prevents bone nodule formation by osteoblasts in vitro by inhibiting mineralisation of the collagenous matrix.
Arnett, T R +4 more
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Glucose availability and sensitivity to anoxia of isolated rat peripheral nerve [PDF]
, 1991 The contrast between resistance to ischemia and ischemic lesions in peripheral nerves of diabetic patients was explored by in vitro experiments. Isolated and desheathed rat peroneal nerves were incubated in the following solutions with different glucose ...
DYCK P. J. +11 more
core +1 more source
Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia [PDF]
, 2011 OBJECTIVE: Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral ...
Bodmer, Michael +4 more
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Journal of Clinical Sciences, 2020 Background: Estimation of the serum pH and base excess as determinants of the adequacy of resuscitation may predict the patient outcome in peritonitis. Materials, Patients and Methods: This was a prospective study conducted in University College Hospital,
O Oludolapo Afuwape +2 more
doaj +1 more source
HMG-CoA Lyase Deficiency: A Retrospective Study of 62 Saudi Patients
Frontiers in Genetics, 2022 3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency (HMG-CoA lyase) is a rare inborn error of leucine degradation and ketone body synthesis, caused by homozygous or compound heterozygous disease-causing variants in HMGCL.
Majid Alfadhel +15 more
doaj +1 more source
EEG Discontinuity and Neonatal Acidosis
Pediatric Neurology Briefs, 1994 The effect of acidosis on cerebral function was evaluated by computerized online EEG monitoring in 14 ventilated preterm infants less than 32 weeks’ gestation at the Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School ...
J Gordon Millichap
doaj +1 more source
Risk factors for fatality in HIV-infected patients with dideoxynucleoside-induced severe hyperlactataemia or lactic acidosis. [PDF]
, 2011 BACKGROUND: Lactic acidosis (LA) and severe hyperlactataemia (HL) are infrequent but serious complications of antiretroviral therapy that have been associated with a high fatality rate.
Arenas-Pinto, Alejandro +12 more
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Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation [PDF]
, 2010 Objective Mitochondrial disturbances of energy-generating systems in childhood are a heterogeneous group of disorders. The aim of this multi-site survey was to characterise the natural course of a novel mitochondrial disease with ATP synthase deficiency ...
Bodamer, O +15 more
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Physiological Reports, 2021 Aim Exercise is able to increase both muscle protein synthesis and mitochondrial biogenesis. However, acidosis, which can occur in pathological states as well as during high‐intensity exercise, can decrease mitochondrial function, whilst its impact on ...
Amanda J. Genders +7 more
doaj +1 more source
Effect of induction of subacute ruminal acidosis on milk fat profile and rumen parameters [PDF]
, 2010 High-concentrate diets can lead to subacute ruminal acidosis and are known to result in changes of the ruminal fermentation pattern and mammary secretion of fatty acids.
Colman, Ellen +5 more
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