Results 111 to 120 of about 9,916,530 (325)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Control y tratamiento médico por ingestión de sustancias cáusticas Control and medical treatment for ingestion of caustic substances

open access: yesMedisan, 2010
Se comunica brevemente lo más actual sobre el control y tratamiento médico por la ingestión de sustancias cáusticas como ácidos y álcalis, así como de las personas que ingieren drogas con el objetivo de transportarlas de forma ilegal.A short report is ...
José Manuel Ricardo Ramírez
doaj  

Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation

open access: yesBiomolecules
The selective regulation of gene expression at the RNA level represents a rapidly evolving field offering substantial clinical potential. This review examines the molecular mechanisms of intracellular enzymatic systems that utilize single-stranded ...
Daria A. Chiglintseva   +2 more
doaj   +1 more source

Nutritive value of tomatillo fruit (Physalis ixocarpa Brot.)

open access: yesActa Societatis Botanicorum Poloniae, 2014
Tomatillo is widely cultivated in Mexico but is little known in other countries. The chemical composition of fruit from field grown plants was investigated during several vegetative seasons. Tomatillo contained a relatively high percentage of dry matter (
Joanna Ostrzycka   +4 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Comparison of Salivary pH, Buffering Capacity and Alkaline Phosphatase in Smokers and Healthy Non-Smokers : Retrospective cohort study

open access: yesSultan Qaboos University Medical Journal, 2016
Objectives: Saliva contains alkaline phosphatase (ALP)—a key intracellular enzyme related to destructive processes and cellular damage—and has buffering capacity (BC) against acids due to the presence of bicarbonate and phosphate ions.
Fatemeh Ahmadi-Motamayel   +3 more
doaj   +1 more source

The Composition of Arylstibonic Acids [PDF]

open access: yes, 2010
This thesis describes a detailed ESI-MS investigation into the arylstibonic acids, organo-antimony-containing compounds that are currently of interest as anticancer reagents. Four arylstibonic acids, of nominal formula RC6H4SbO3H2 [R = p-chloro-, p-tolyl-
Wright, Cody Elvin
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Perfil de ácidos grasos en pacientes oncológicos pediátricos Plasma fatty acids profile in paediatric cancer patients

open access: yesNutrición Hospitalaria, 2012
El reducido número de casos de cáncer en la edad pediátrica y las dificultades para la investigación, han contribuido a que existan escasos estudios sobre el estado metabólico y nutricional de estos pacientes.
M.ª J. de la Torre Aguilar   +4 more
doaj  

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