Enhanced Hybridization Selectivity Using Structured GammaPNA Probes
Molecules, 2020 High affinity nucleic acid analogues such as gammaPNA (γPNA) are capable of invading stable secondary and tertiary structures in DNA and RNA targets but are susceptible to off-target binding to mismatch-containing sequences.
Taylor D. Canady +6 more
doaj +1 more source
Fluorinated esters of polycarboxylic acids [PDF]
, 1973 Fluorine containing esters of polycarboxylic acids are discussed.
Breed, L. L., Elliott, R. L.
core +1 more source
Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis [PDF]
, 2007 Epidemiological, biochemical, animal model and clinical trial data described in this overview strongly suggest that polyunsaturated fatty acids, particularly n-6 fatty acids, have a role in the pathogenesis and treatment of multiple sclerosis (MS).
Copeland +16 more
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Characterization of Cupriavidus eutrophus В-10646 Culture Synthesizing Polyhydroxyalkanoates Grown on Sugars And Lipidic Substrates [PDF]
Журнал Сибирского федерального университета: Серия Биология, 2014 Growth, polyhydroxyalkanoates (PHAs) accumulation and total fatty acid composition of the lipids of Cupriavidus eutrophus B-10646 were studied, using various carbon sources (fructose, glucose, oleic acid, sunflower seed oil).
Natalia O. Zhila +2 more
doaj
The balance between fumarate and malate plays an important role in plant development and postharvest quality in tomato fruit [PDF]
, 2018 Organic acids, produced as intermediates of the tricarboxylic cycle, play a crucial role in the plant primary metabolism and are considered as being ones of the most important quality traits in edible fruits.
Fernie, Alisdair R +5 more
core
Distances and classification of amino acids for different protein secondary structures
, 2003 Window profiles of amino acids in protein sequences are taken as a description of the amino acid environment. The relative entropy or Kullback-Leibler distance derived from profiles is used as a measure of dissimilarity for comparison of amino acids and ...
J. Garnier +10 more
core +2 more sources
Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase [PDF]
, 2015 Background Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized.
Ala-Korpela, M +25 more
core +2 more sources
Cell, 2010 The mTORC1 kinase promotes growth in response to growth factors, energy levels, and amino acids, and its activity is often deregulated in disease.
Y. Sancak +5 more
semanticscholar +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source