MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2 [PDF]
Journal of Biological Chemistry, 2018 Chemokines are the principal regulators of leukocyte migration and are essential for initiation and maintenance of inflammation. Atypical chemokine receptor 2 (ACKR2) binds and scavenges proinflammatory CC-chemokines, regulates cutaneous T-cell ...
Burden, AD +5 more
core +6 more sources
Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice [PDF]
Journal of Diabetes Research, 2016 In diabetic nephropathy (DN) proinflammatory chemokines and leukocyte infiltration correlate with tubulointerstitial injury and declining renal function.
Shirong Zheng +6 more
doaj +3 more sources
Integrated bioinformatics analysis reveals that CCBP2 and GPR87 are new GPCR-associated biomarkers for preeclampsia [PDF]
Reproductive Biology and EndocrinologyBackground Preeclampsia (PE) is a multifaceted pregnancy syndrome marked by multiple system involvement and a significant contributor to maternal mortality.
Jie Li +3 more
doaj +2 more sources
Eosinophils promote monocyte to macrophage differentiation and anti-bacterial immunity [PDF]
Chemokine receptors control cell migration within the body. Here we reveal a novel interaction between eosinophils and monocytes in the bone marrow, indirectly controlled by the atypical chemokine receptor ACKR2.
Wilson GJ +10 more
europepmc +2 more sources
Enhanced CCR2 expression by ACKR2-deficient NK cells enhances increases tumoricidal cell therapy efficacy [PDF]
Journal of Leukocyte BiologyChemokines regulate leukocyte navigation to inflamed sites and specific tissue locales and may therefore be useful for ensuring accurate homing of cell therapeutic products.
Bartolini, Robin +14 more
core +3 more sources
THE NEUTROPHIL ANTI-TUMORAL RESPONSE IN CANCER: ROLE OF ACKR2 AND CHEMOKINE RECEPTORS [PDF]
, 2018 Chemokines are key mediators of inflammation and are involved in both extrinsic and intrinsic pathway of cancer. Their main function is to induce leukocyte migration through the binding of specific seven transmembrane receptors.
M. Massara
core +2 more sources
Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation. [PDF]
Mediators InflammAutoimmune disorders encompass a varied range of diseases in which the immune system mistakenly targets and attacks the body’s own tissues. The causes of the conditions are unknown. It is presumed that various genetic, environmental, and immune factors all play a part.
Farahani H +4 more
europepmc +2 more sources
Corrigendum: ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology [PDF]
Frontiers in Immunology, 2017 Ornella Bonavita +9 more
doaj +2 more sources
Bystander Expression of Atypical Chemokine Receptor 2 Protects T Cells from Chemoattraction towards Cancer-Associated Fibroblasts. [PDF]
Eur J ImmunolCancer‐associated fibroblasts (CAFs) secrete chemokines that attract T cells. Here we show that the overexpression of atypical chemokine receptor 2 (ACKR2) by bystander cells scavenges key chemokines secreted by CAFs, including previously unreported ligands CXCL12 and CXCL1, and thereby protects T cells from chemoattraction by CAFs.
Tang R +7 more
europepmc +2 more sources