Die Beeinflussung des akuten und chronischen Ischämie-Reperfusionsschadens in der Niere durch das Chemokin-bindende Molekül ACKR2 [PDF]
Nach einem Ischämie-Reperfusionsschaden in der Niere erlaubt ein Rückgang der Entzündungsreaktion eine Regeneration und Heilung des Tubulusepithels. Wenn die Entzündungsreaktion aber persistiert oder gar voranschreitet, kommt es zu einem andauernden ...
Lux, Moritz
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The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens [PDF]
Immunology & Cell Biology, 2014 Chemokine‐directed leukocyte migration is a critical component of all innate and adaptive immune responses. The atypical chemokine receptor ACKR2 is expressed by lymphatic endothelial cells and scavenges pro‐inflammatory CC chemokines to indirectly subdue leukocyte migration.
Hansell, Chris AH +9 more
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Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2 [PDF]
Journal of Investigative Dermatology, 2017 Elucidating the poorly defined mechanisms by which inflammatory lesions are spatially restricted in vivo is of critical importance in understanding skin disease. Chemokines are the principal regulators of leukocyte migration and are essential in the initiation and maintenance of inflammation.
Shams, K +9 more
openaire +7 more sources
Targeting the atypical chemokine receptor 2 (<i>Ackr2</i>) improves the benefit of anti-PD-1 immunotherapy in melanoma mouse model. [PDF]
OncoimmunologyImmune checkpoint blockade (ICB) therapies, such as anti-PD-1, have transformed cancer treatment, but many patients do not respond due to a non-inflammatory tumor microenvironment (TME). Here, we investigated the impact of targeting Atypical Chemokine Receptor 2 (ACKR2), which scavenges key chemokines involved in immune cell recruitment, on the ...
Noman MZ +9 more
europepmc +4 more sources
A guide to chemokines and their receptors [PDF]
, 2018 The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A +11 more
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Extended repertoire of CXC chemokines acting as agonists and antagonists of the human and murine atypical chemokine receptor ACKR2. [PDF]
J Leukoc BiolAbstract Atypical chemokine receptors are a subfamily of important regulators of chemokine functions. Among them, ACKR2 has long been considered a scavenger of multiple inflammatory chemokines exclusively from the CC family. Recently, we demonstrated the ability of ACKR2 to scavenge the CXC chemokine CXCL10, previously reported to bind ...
Luís R +3 more
europepmc +3 more sources
Chemokine receptors coordinately regulate macrophage dynamics and mammary gland development [PDF]
, 2020 Macrophages are key regulators of developmental processes, including those involved in mammary gland development. We previously demonstrated that the atypical chemokine receptor, ACKR2, contributes to control of ductal epithelial branching in the ...
Fukuoka, Ayumi +6 more
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Functional characterization of a short peptidoglycan recognition protein from Chinese giant salamander (Andrias davidianus) [PDF]
, 2017 This work was supported by the National Natural Science Foundation of China (Grant no. 31302221, 31172408 and 31272666) and Jiangsu Province (Grant no.
Chang, Mingxian +8 more
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Distinct Differentiation Programs Triggered by IL-6 And LPS in Teleost IgM+ B Cells in the Absence of Germinal Centers [PDF]
, 2016 We would like to thank Lucia Gonzalez and Maria Sanz for technical assistance. Professor Øystein Evensen is also acknowledged for providing us with the inactivated IPNV.
Abós, Beatriz +9 more
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Identification of the salmonid IL-17A/F1a/b, IL-17A/F2b, IL-17A/F3 and IL-17N genes and analysis of their expression following in vitro stimulation and infection [PDF]
, 2015 Peer ...
Husain, Mansourah +5 more
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