Results 51 to 60 of about 1,254 (143)

ACKR2 contributes to pulmonary dysfunction by shaping CCL5:CCR5-dependent recruitment of lymphocytes during influenza A infection in mice [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2020
Inflammation triggered by influenza A virus (IAV) infection is important for viral clearance, induction of adaptive responses, and return to lung homeostasis. However, an exaggerated immune response, characterized by the overproduction of chemokines, can lead to intense lung injury, contributing to mortality.
Luciana P. Tavares, Cristiana C. Garcia, Ana Paula F. Gonçalves, Lucas R. Kraemer, Eliza M. Melo, Fabrício M. S. Oliveira, Camila S. Freitas, Gabriel A. O. Lopes, Diego C. Reis, Geovanni D. Cassali, Alexandre M. Machado, Alberto Mantovani, Massimo Locati, Mauro M. Teixeira, Remo C. Russo   +14 more
openaire   +2 more sources

CXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide‐ and Dexamethasone‐Induced Muscle Atrophy in Cultured Myotubes and Mouse Models

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Skeletal muscle mass is regulated by secretory factors derived from myofibers and muscle‐resident cells. Identifying these factors and understanding their mechanisms is critical for combating muscle wasting disorders. This experimental study investigates the role of CXCL14, a chemokine primarily secreted by fibro‐adipogenic ...
Bagus Sarmito, Younjeong Oh, Nurkyz Alymkulova, Jeong Kyo Yoon   +3 more
wiley   +1 more source

The N-terminal Region of the Atypical Chemokine Receptor ACKR2 Is a Key Determinant of Ligand Binding [PDF]

Journal of Biological Chemistry, 2014
The atypical chemokine receptor, ACKR2 is a pivotal regulator of chemokine-driven inflammatory responses and works by binding, internalizing, and degrading inflammatory CC-chemokines. ACKR2 displays promiscuity of ligand binding and is capable of interacting with up to 14 different inflammatory CC-chemokines.
Hewit, Kay D., Fraser, Alasdair, Nibbs, Robert J.B., Graham, Gerard J.   +3 more
openaire   +3 more sources

Patient-Oriented Perspective on Chemokine Receptor Expression and Function in Glioma. [PDF]

, 2021
peer reviewedGliomas are severe brain malignancies, with glioblastoma (GBM) being the most aggressive one. Despite continuous efforts for improvement of existing therapies, overall survival remains poor. Over the last years, the implication of chemokines
Isci, Damla, D'Uonnolo, Giulia, Wantz, May, Rogister, Bernard, LOMBARD, Arnaud, Chevigné, Andy, Szpakowska, Martyna, Neirinckx, Virginie   +7 more
core   +1 more source

Genetically Determined Inflammation‐Related Proteins in Asthma and Type‐2 Signatures

Allergy, Volume 80, Issue 6, Page 1702-1714, June 2025.
This study investigates the association between genetic variation and inflammation‐related plasma proteins, and the differences in the proteins genetically determined between subjects with type‐2 signatures and/or asthma. Our findings suggest a strong contribution of genetic variation to the inflammation‐related proteome.
Natalia Hernandez‐Pacheco, Sophia Björkander, Simon Kebede Merid, Maura Kere, Ashish Kumar, Susanna Klevebro, Ida Mogensen, Sandra Ekström, Christer Janson, Lena Palmberg, Marianne van Hage, Anders Mälarstig, Anne‐Sophie Merritt, Göran Pershagen, Anna Bergström, Inger Kull, Jochen M. Schwenk, Erik Melén   +17 more
wiley   +1 more source

Cross-genetic determination of maternal and neonatal immune mediators during pregnancy. [PDF]

, 2018
BACKGROUND:The immune system plays a fundamental role in development during pregnancy and early life. Alterations in circulating maternal and neonatal immune mediators have been associated with pregnancy complications as well as susceptibility to ...
Ashwood, Paul, Croen, Lisa A, DeLorenze, Gerald N, Heuer, Luke S, Jones, Karen L, Kharrazi, Martin, Traglia, Michela, Van de Water, Judy, Weiss, Lauren A, Yolken, Robert   +9 more
core  

Resolution of inflammation: a new therapeutic frontier [PDF]

, 2016
Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success.
A Ariel, A Ariel, A Basran, A Boasso, A Chatterjee, A Devitt, A Kovalenko, A Recchiuti, A Recchiuti, A Rossi, AB Shyu, AE Leitch, AE Leitch, AG Rossi, AG Rossi, AG Rossi, AG Rossi, AI Medeiros, AJ Degraaf, AJ O'Brien, AL Alessandri, AL Alessandri, AL Robertson, AP Cope, AW Segal, B Amulic, B Bondue, B Geering, B Gemici, B Leon, BA Zabel, BJ Evans, C Favas, C Godson, C Qin, C Schauer, C von Roretz, C Yao, CA Wijbrandts, CC Mihalache, CD Buckley, CD Buckley, CD Gregory, CE Clay, CH Fong, CN Serhan, CN Serhan, CN Serhan, CW Yang, D Bhaumik, D El Kebir, D Park, DA Isenberg, DA Sawatzky, DC Cara, Derek W. Gilroy, DH Rodrigues, DR Gude, DS Straus, DW Gilroy, DW Gilroy, DW Gilroy, E Carballo, E Carballo, E Perdiguero, E Tili, EB Wilson, EE McGrath, EL Hahn, ES Mocarski, EY Chung, F Mariani, FJ Sheedy, FK Chan, FK Swirski, FM Menzies, FN Gavins, FS Machado, G D'Agostino, G Fredman, G Song, G Stoecklin, GA Rabinovich, GJ Bellingan, GJ Graham, GJ Graham, GL Bannenberg, H Braley-Mullen, H Muhl, H Nakano, H Seki, HJ Anders, HT Chung, I Allaeys, I McConnell, I Mitroulis, I Mitroulis, I Sauer, IK Poon, J Bystrom, J Bystrom, J Bystrom, J Gong, J Hopkins, J Liang, J Liu, J Liu, J Newson, J Savill, J Savill, J Seok, James N. Fullerton, JD Langereis, JD Pollock, JL Cash, JL Wallace, JM Gonzalez-Navajas, JM Schwab, JP Vago, JR Brown, JR Teijaro, JW Zmijewski, K Ersland, K Horino, K Lauber, K Linker, K Matsushita, K Miles, K Phillips, K Sasaki, K Takao, K Uchida, K Vyas, KD Taganov, KE Blume, KH Weylandt, KP High, L Arnold, L Chen, L Li, L Sun, LJ Harvey, LM Wakim, LP Sousa, LP Sousa, LR Prince, LS van Rijt, M Back, M Brittan, M Drechsler, M Feoktistova, M Kool, M Lagarde, M Mavers, M Perretti, M Perretti, M Piecyk, M Romano, M Romano, M Rosas, M Singh, M Vukmanovic-Stejic, MA Nahid, MC Martin, MF Schmidt, MG Johnston, MM Chan, MM Matzelle, MM Perry, MR Elliott, MR Jones, MR Junttila, MS Bynoe, MS Chapman, MT Elola, N Chiang, N Chiang, N Dufton, NC Henderson, NM Reddy, P Anderson, P Anderson, P Libby, P Ramachandran, P Sampath, PA Insel, Q Remijsen, R Gyurko, R Mounier, R Mukhopadhyay, R Pettipher, R Rajakariar, R Rajakariar, R Tomasini, RJ Nibbs, RL Ogilvie, RL Ogilvie, RM Day, RM Dores, RM Thurlings, RN Cahill, S Bala, S Brown, S Divanovic, S Krishnamoorthy, S Mi, S Parathath, S Schif-Zuck, S Uderhardt, S Yazid, S Yona, SB Berger, SG Trivedi, SJ Gardai, SJ Nicholls, SW Jones, SW Ryter, T Brzoska, T Hisada, T Lawrence, T Montero-Melendez, T Shay, T Vanden Berghe, U Koedel, UE Knies, V Deretic, VA Fadok, VA Fadok, VA Fadok, VA Fadok, VA Fadok, W Jenner, WH Shao, WJ Kim, WR Hansen, Y Fang, Y Fang, Y Okabe, Y Uehara, YL Chen   +239 more
core   +1 more source

Relationship Between MCP‐1 Levels in GCF and Periodontitis: A Systematic Review With Meta‐Analysis and Analysis of Molecular Interactions

Journal of Cellular and Molecular Medicine, Volume 29, Issue 9, May 2025.
ABSTRACT Monocyte chemoattractant protein 1 (MCP‐1) is involved in monocyte chemotaxis, endothelial activation and regulation of leukocyte function in biological activities that promote inflammation, such as in periodontitis. A systematic review and meta‐analysis was conducted with the primary objective of investigating the roles of MCP‐1 in the ...
Mario Alberto Alarcón‐Sánchez, Ruth Rodríguez‐Montaño, Sarah Monserrat Lomelí‐Martínez, Artak Heboyan   +3 more
wiley   +1 more source

The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury [PDF]

, 2017
The atypical chemokine receptor ACKR2 promotes resolution of acute inflammation by operating as a scavenger receptor for inflammatory CC chemokines in several experimental models of inflammatory disorders, however its role in the brain remains unclear ...
B. Savino, B.D. Semple, C. Sobacchi, M. Locati, M. Massara, M.C. Morganti-Kossmann, N. Bye, R. Besio, T. Frugier, T.M. Woodcock, T.T. Nguyen   +10 more
core   +4 more sources

DOWN-REGULATION OF ATYPICAL CHEMOKINE RECEPTOR ACKR2/D6 EXPRESSION BY HEMATOPOIETIC PROGENITORS PROMOTES MYELOID CELL MOBILIZATION AND DIFFERENTIATION [PDF]

, 2017
Chemokines and chemokine receptors are key mediators of inflammation and important regulators of leukocyte migration in homeostatic conditions as well as during infection and cancer.
O. Bonavita
core   +1 more source