International Journal of Food Properties, 2023 The rising prevalence and detrimental impact of inflammatory diseases have spurred the exploration of novel therapeutic approaches to tackle these conditions. Fuzi, lateral root of Aconitum carmichaelii Debx.
Zufeng Zhang +7 more
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Pharmacological effects, molecular mechanisms, and pharmacokinetics of benzoylaconine: a systematic review [PDF]
Frontiers in PharmacologyBenzoylaconine (BAC), a key active metabolite in traditional Chinese medicine, is derived from the subsoil roots of Fuzi (Aconitum carmichaelii Debx [Ranunculaceae, Aconitum carmichaelii Debx roots]).
Huamei Zhuang +3 more
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Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling [PDF]
Frontiers in PharmacologyBackground: Mesaconitine (MA), a diester-diterpenoid alkaloid extracted from the medicinal herb Aconitum carmichaelii, is commonly used to treat various diseases. Previous studies have indicated the potent toxicity of aconitum despite its pharmacological
Xiaohuang Lin +15 more
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Divergent multifunctional P450s-empowered biosynthesis of bioactive tripterifordin and cryptic atiserenoids in Aconitum implies convergent evolution [PDF]
Nature CommunicationsDiterpenoids exhibit remarkable structural diversity and bioactivities, shaped primarily by the tandem actions of skeleton-forming terpene synthases (TPSs) and cytochrome P450 monooxygenases.
Fei Luo +6 more
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Biological ControlSouthern blight and root rot were two main soil-borne diseases of Aconitum carmichaelii Debeaux, a famous medicinal plant rich in alkaloids. Beneficial microbe based biological control has been a promising and sustainable alternative for disease control.
Qian Wang +7 more
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Genetic diversity and marker–trait association analysis for agronomic traits in Aconitum carmichaelii Debeaux [PDF]
Biotechnology & Biotechnological Equipment, 2017 The root of Aconitum carmichaelii Debeaux is used in Oriental folk medicine, but its cultivation is very labour intensive. Therefore, it is important to dissect the genetic mechanism of agronomic traits to breed elite cultivars for commercial cultivation.
Ma Yu +9 more
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Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis [PDF]
Drug Design, Development and TherapyYidong Cui,1 Qingming Liu,2 Qiqiang Zhang,3 Xuemei Di,3 Hai Zhang3 1Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, People’s Republic of China;
Cui Y, Liu Q, Zhang Q, Di X, Zhang H
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Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids [PDF]
, 2021 Diterpenoid alkaloids are natural compounds having complex structural features with many stereo-centres originating from the amination of natural tetracyclic diterpenes and produced primarily from plants in the Aconitum, Delphinium, Consolida genera ...
Bufo S. A. +4 more
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Journal of Ethnopharmacology, 2023 ETHNOPHARMACOLOGICAL RELEVANCE The lateral root of Aconitum carmichaelii Debx is known as Fuzi in Chinese. It is traditionally valued and used for dispelling cold, relieving pain effects, restoring 'Yang,' and treating shock despite its high toxicity ...
G. He +7 more
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BMEMat, 2023 Background Aconitum carmichaelii, the mother root of Aconitum, has a long‐applied history for treating many diseases in China. Increased use of it has prompted significant concerns regarding its extensive cardiotoxicity and neurotoxicity.
Meijun Pang +10 more
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