Results 51 to 60 of about 1,015 (136)

Fig. 2. Key 1H–1H in Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/ P-STAT3 pathways

, 2023
Fig. 2. Key 1H–1H COSY and HMBC correlations of 1–6.Published as part of Zhou, Yin-Lin, Zhang, Duan-Na, Qiao, Ji-Xu, Wu, Jing, Yan, Yong-Ming, Cao, Zhi-Xing, Peng, Cheng & Tan, Yu-Zhu, 2023, Diverse alkaloids from the aerial parts of Aconitum ...
Wu, Jing, Cao, Zhi-Xing, Zhou, Yin-Lin, Zhang, Duan-Na, Yan, Yong-Ming, Peng, Cheng, Tan, Yu-Zhu, Qiao, Ji-Xu   +7 more
core   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Reducing Neuroinflammation via Inhibition of Fibrinogen Deposition and Microglial Activation as an Underlying Mechanism of Paning I Decoction in Ameliorating Parkinson's Disease Symptoms

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
Paning I decoction alleviated neuroinflammation in Parkinson's disease. ABSTRACT Background Parkinson's disease (PD) is a major neurodegenerative disorder. Some patients show limited response to standard therapies, driving the need for new complementary treatments.
Yan‐Jun Chen, Jing‐Wen Chen, Ming‐Rong Xie, Rui‐Zhen Wang, Yu‐Ling Wan, Jie Zeng, Bing‐Wu Zhong, Sheng‐Qiang Zhou, Fang Liu   +8 more
wiley   +1 more source

Integrating Traditional Wisdom With Modern Science: Ginsenosides as Antiheart Failure Agents

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Heart failure (HF), as the terminal stage of various cardiovascular diseases, remains a global health challenge with persistently high morbidity and mortality rates. Although current therapies—including angiotensin receptor–neprilysin inhibitors, sodium‐glucose cotransporter‐2 inhibitors, and cardiac resynchronization therapy—have improved outcomes ...
Li Zhou, Yanhua Li, Wenjie Yin, Xi Gu, Jiana Shi, Fan Yang, Satabdi Datta Choudhury   +6 more
wiley   +1 more source

Pharmacological effects, molecular mechanisms, and pharmacokinetics of benzoylaconine: a systematic review

Frontiers in Pharmacology
Benzoylaconine (BAC), a key active metabolite in traditional Chinese medicine, is derived from the subsoil roots of Fuzi (Aconitum carmichaelii Debx [Ranunculaceae, Aconitum carmichaelii Debx roots]).
Huamei Zhuang, Huamei Zhuang, Hong Yao, Hong Yao   +3 more
doaj   +1 more source

Chinese Herbal Medicines for Diabetic Cardio‐Cerebrovascular Diseases: Key Bioactive Metabolites and Action Mechanisms

Journal of Nutrition and Metabolism, Volume 2026, Issue 1, 2026.
Currently, the global incidence of diabetes is increasing, particularly in populous developing regions. In China, over 290 million people are affected by diabetic cardio‐cerebrovascular diseases. These diseases account for more than 40% of deaths and impose a significant economic burden on both society and families.
Ying Su, Shuwen Luo, Wei Li, Cuicui Cheng, Wei Liu, Xinyu Yang, Zhen Xing, Eric Gumpricht   +7 more
wiley   +1 more source

Identification of antagonistic fungi and their antifungal activities against aconite root rot pathogens

Plant Signaling & Behavior, 2023
Root rot is one of the main diseases affecting Aconitum carmichaelii Debx. during cultivation, seriously limiting yields of this herb. Currently, there is no effective control measure for aconite root rot.
Ran Liu, Maoting Chen, Jing Gao, Min Luo, Guangzhi Wang   +4 more
doaj   +1 more source

Identification of Anti‐Inflammatory and Analgesic Mechanisms of Naru‐3 Wei Pill Using Animal Models, UHPLC‐QE‐MS, and Integrated Network Pharmacology

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Naru‐3 Wei Pill is a traditional Mongolian Medicine (TMM) that has anti‐inflammatory, analgesic, and antibacterial effects. The present study aimed to demonstrate the anti‐inflammatory and analgesic effect of Naru‐3 Wei Pill, identify the core components and key targets and determine the pharmacological basis and mechanism of its blood‐borne
Zhiqiang Han, Husile Kang, Aidi Zhang, Qigeqin, Baolechaolu, Wulanqiqige, Huan Wang, Yanhua Xu, HaSi, Anda, Lan Xue, K. Sony Reddy   +11 more
wiley   +1 more source

Pharmacokinetics of 10-Hydroxy Mesaconitine in Rat Plasma by Ultra-Performance Liquid Chromatography-Tandem Quadrupole Mass Spectrometry

Journal of Analytical Methods in Chemistry, 2021
Mesaconitine is the predominant active ingredient in Aconitum carmichaelii Debx. The compound 10-hydroxy mesaconitine is one known metabolite of mesaconitine and is toxic.
Jinzhao Yang, Guowu Zeng, Jianshe Ma, Xianqin Wang, Quan Zhou   +4 more
doaj   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source