Results 71 to 80 of about 965 (148)

Integration of pharmacochemistry, pharmacodynamics and metabolomics to reveal active ingredients and mechanism of Nan Bao detox capsule alleviating methamphetamine addiction

Addiction Biology, Volume 29, Issue 11, November 2024.
Experimental flowchart: NBDC is composed of various medicinal materials such as ginseng, astragalus and polygala. UPLC‐MS is used to analyse the components of NBDC. MA addiction rats is administered with NBDC. Blood samples are subjected to metabolomic analysis.
Bin Zhang, Chen Yang, Yuxiao Zheng, Xinliang Li, Xingguo Wang, Li Yuehui   +5 more
wiley   +1 more source

Bioactive polysaccharides and phenolic compounds from two Aconitum plants: Aconitum carmichaelii and Aconitum septentrionale

, 2023
The traditional use and poisonous properties of Aconitum species are mainly due to the presence of alkaloids, which have been extensively studied. However, limited attention has been paid to their low-toxic natural products. In this thesis, diverse bioactive non-starch polysaccharides, including mannans, pectin, and/or xyloglucans, were shown to be ...
openaire   +2 more sources

Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling

Frontiers in Pharmacology
Background: Mesaconitine (MA), a diester-diterpenoid alkaloid extracted from the medicinal herb Aconitum carmichaelii, is commonly used to treat various diseases. Previous studies have indicated the potent toxicity of aconitum despite its pharmacological
Xiaohuang Lin, Jian Zhang, Jian Zhang, Zekai Wu, Yuan Shi, Mengting Chen, Maodong Li, Hong Hu, Kun Tian, Xiaoqi Lv, Chutao Li, Yang Liu, Xinyue Gao, Qiaomei Yang, Kunqi Chen, An Zhu   +15 more
doaj   +1 more source

Therapeutic potential and molecular mechanisms of Yi-Yi-Fu-Zi-Bai-Jiang-San in the treatment of colorectal cancer

Frontiers in Pharmacology
Colorectal cancer (CRC) is one of the most common gastrointestinal tumors with elevated prevalence and high mortality rates, posing a serious threat to human health.
Jinxiao Li, Jinxiao Li, Keke Jiang, Shuhan Wang, Yuju Cai, Luorui Shang, Fangyuan Zhou, Yuqing Wang, Jianghua Huang, Shan Hu, Qian Yan, Qian Yan, Shenglan Yang   +12 more
doaj   +1 more source

Effects of an Isolate of Bacillus subtilis on Southern Blight Severity of Aconitum carmichaelii Debeaux and Its Rhizosphere Microbial Community

Plants
Southern blight caused by Sclerotium rolfsii is a devastating soil-borne disease of Aconitum carmichaelii, a medicinal plant widely cultivated in China. Biological control using beneficial bacteria offers a sustainable alternative to chemical fungicides.
Xiaofang Sun, Yong Liu, Pengsheng Ye, Lian He, Shundong Dai, Zaiyin Kuang, Qiuping Jiang, Hualan Zeng   +7 more
doaj   +1 more source

Virome Analysis of Aconitum carmichaelii Reveals Infection by Eleven Viruses, including Two Potentially New Species. [PDF]

Int J Mol Sci, 2023
Yang J, Lan PX, Wang Y, Li JM, Li R, Wylie S, Chen XJ, Yang GH, Cai H, Li F.   +9 more
europepmc   +1 more source

Assembly and Comparative Analysis of Aconitum soongaricum Mitochondrial Genome Provides Insights into Its Identification and Function

Horticulturae
Aconitum soongaricum, a medicinal plant endemic to the Tianshan Mountains in Xinjiang, China, produces numerous natural compounds with potential medicinal value. Mitochondria function as energy hubs and play critical roles in plant development and stress
Shimeng Cui, Jingyuan Ren, Yangyang Chen, Ziling Liu, Jieru Chen, Fengru Lv, Sixuan Li, Jiayu Zhou, Xiaozhu Zhao, Hai Liao   +9 more
doaj   +1 more source

Aconitum carmichaelii Debx. Attenuates Heart Failure through Inhibiting Inflammation and Abnormal Vascular Remodeling. [PDF]

Int J Mol Sci, 2023
Xing Z, Chen J, Yu T, Li X, Dong W, Peng C, Li D.   +6 more
europepmc   +1 more source

Aconitum carmichaelii: a clinical-regulatory synthesis of traditional use, toxicological evidence, and global safety governance

Frontiers in Pharmacology
Aconitum carmichaelii Debeaux (Ranunculaceae), commonly used as Aconiti Lateralis Radix Praeparata (Fuzi), is a clinically important but highly toxic herb in traditional Chinese medicine.
Ru Ya Tan, Pin Jun Ooi, Xiangyang Xu, Xu Wei, Xu Wen, Qiyue Qiu, Mun Fei Yam, Mun Fei Yam   +7 more
doaj   +1 more source

Processed lateral root of Aconitum carmichaelii Debx.: A review of cardiotonic effects and cardiotoxicity on molecular mechanisms. [PDF]

Front Pharmacol, 2022
Zhang J, Li D, Zhong D, Zhou Q, Yin Y, Gao J, Peng C.   +6 more
europepmc   +1 more source