Results 71 to 80 of about 1,015 (136)

Preventive Effect of Shenfu Injection on Arrhythmia After Percutaneous Coronary Intervention in Patients With ST‐Segment Elevation Myocardial Infarction: A Prospective Randomized Controlled Trial

Cardiovascular Therapeutics, Volume 2025, Issue 1, 2025.
Background and Aims Arrhythmias and major adverse cardiac events remain significant complications following ST‐segment elevation myocardial infarction (STEMI). Shenfu injection, a traditional Chinese medicine formulation, has shown cardioprotective effects in preclinical studies.
Xiaohan Qiu, Yue Wang, Jiahan Ke, Min Wang, Huasu Zeng, Huafang Zhu, Jun Gu, Hangang Yu   +7 more
wiley   +1 more source

ZIF‐8 Selective Dispersive Solid‐Phase Extraction‐LC‐MS/MS Method for the Determination of Aconitine alkaloids in Rat Plasma: Application in Pharmacokinetic Studies

Journal of Analytical Methods in Chemistry, Volume 2025, Issue 1, 2025.
Objective: Aconitine alkaloids, as the principal bioactive constituents of Fuzi, pose a significant challenge to its clinical application due to their toxicity. This study aimed to establish a rapid, efficient, and stable method for quantifying monoester‐type and diester‐type alkaloids in raw Fuzi using zeolitic imidazolate framework‐8 (ZIF‐8).
Yang Yang, Liu Renyan, Xin Lingyi, Feng Baodong, Zhang Yu, Su Linqi, Ming Tingwen, Liu Jingjian, Chen Qinhua, Adrián Gutiérrez-Serpa   +9 more
wiley   +1 more source

Aqueous extract of Aconitum carmichaelii Debeaux attenuates sepsis-induced acute lung injury via regulation of TLR4/NF-ΚB pathway

, 2020
Purpose: To investigate the therapeutic effect of aqueous extract of Aconitum carmichaelii Debeaux (AEACD) on sepsis-induced acute lung injury (ALI), as well as explore the underlying mechanism of action.
Li, Wenmei, Wang, Jinmei, Jiang, Lijuan, You, Qinghai, Chang, Yuanmin   +4 more
core   +1 more source

Fig. 4. Compound 1 in Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/ P-STAT3 pathways

, 2023
Fig. 4. Compound 1 inhibited invasion of HCT116 colon cancer cells in a transwell assay, which showed by representative images (A) and attached data (B). Cells were incubated with compound 1 (a) 0 μM, (b) 5 μM, (c) 10 μM for 24 h (original magnification,
Wu, Jing, Cao, Zhi-Xing, Zhou, Yin-Lin, Zhang, Duan-Na, Yan, Yong-Ming, Peng, Cheng, Tan, Yu-Zhu, Qiao, Ji-Xu   +7 more
core   +1 more source

EXPRESSION OF CONCERN: The Cardiovascular Protective Function of Natural Compounds Through AMPK/SIRT1/PGC‐1α Signaling Pathway

Food Science &Nutrition, Volume 12, Issue 12, Page 9998-10009, December 2024.
Cardiovascular disease (CVD) is a major threat to human health and imposes a heavy burden on individuals, society, and healthcare systems. A key goal of our search was to find natural compounds that target this biological pathway and have beneficial effects on CVD.
Sohrab Rahmani, Ali Roohbakhsh, Vahid Pourbarkhordar, Gholamreza Karimi   +3 more
wiley   +1 more source

Unlocking the hidden potential: enhancing the utilization of stems and leaves through metabolite analysis and toxicity assessment of various parts of Aconitum carmichaelii

Ethnopharmacological relevance: Aconitum carmichaelii is widely used in traditional Chinese medicine clinics as a bulk medicinal material. It has been used in China for more than two thousand years.
Wu, Jing, Wang, Yulan, Chu, Tianzhe, Qu, Can, Tan, Yuzhu, Kang, Qinzhao, Peng, Cheng, Zhou, Yinlin, Yan, Hongling   +8 more
core   +1 more source

An Optimized Two-Dimensional Quantitative Nuclear Magnetic Resonance Strategy for the Rapid Quantitation of Diester-Type C₁₉-Diterpenoid Alkaloids from Aconitum carmichaelii

, 2023
With the development of nuclear magnetic resonance (NMR) spectrometers and probes, two-dimensional quantitative nuclear magnetic resonance (2D qNMR) technology with a high signal resolution and great application potential has become increasingly ...
Chunwang Meng (15709671), Liang Xiong (1426411), Juan Liu (6492), Qiao Lin (1943722), Jie Liu (15128), Qinmei Zhou (15709674), Cheng Peng (118834), Fei Liu (21082)   +7 more
core   +1 more source

Matrix Metalloproteinases on Skin Photoaging

Journal of Cosmetic Dermatology, Volume 23, Issue 12, Page 3847-3862, December 2024.
ABSTRACT Background Skin aging is characterized by an imbalance between the generation and degradation of extracellular matrix molecules (ECM). Matrix metalloproteinases (MMPs) are the primary enzymes responsible for ECM breakdown. Intrinsic and extrinsic stimuli can induce different MMPs.
Chao Feng, Xianglong Chen, Xiuqing Yin, Yanfei Jiang, Chunyue Zhao   +4 more
wiley   +1 more source

Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition

, 2022
The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount of waste material, especially leaves.
Fu, Yu-Ping, Inngjerdingen, Kari Tvete, Peng, Xi, Wangensteen, Helle, Li, Cen-Yu, Zou, Yuan-Feng   +5 more
core   +1 more source

Integration of pharmacochemistry, pharmacodynamics and metabolomics to reveal active ingredients and mechanism of Nan Bao detox capsule alleviating methamphetamine addiction

Addiction Biology, Volume 29, Issue 11, November 2024.
Experimental flowchart: NBDC is composed of various medicinal materials such as ginseng, astragalus and polygala. UPLC‐MS is used to analyse the components of NBDC. MA addiction rats is administered with NBDC. Blood samples are subjected to metabolomic analysis.
Bin Zhang, Chen Yang, Yuxiao Zheng, Xinliang Li, Xingguo Wang, Li Yuehui   +5 more
wiley   +1 more source