Results 41 to 50 of about 3,156,736 (262)
Critical reviews in oncology/hematologyImmune thrombocytopenia (ITP) is a common acquired autoimmune hemorrhagic disorder characterized by both accelerated platelet destruction and defective thrombopoiesis.
Xin Zhou, Ning-ning Shan
semanticscholar +1 more source
Mixed-model QSAR at the glucocorticoid and liver X receptors [PDF]
, 2009 The presence of hormonally active compounds in the biosphere has become a worldwide environmental concern, and measures such as policy acts and regulations try to address the problem, both in Europe and in the United States.
Spreafico, Morena
core +1 more source
Brain Miffed by Macrophage Migration Inhibitory Factor
International Journal of Cell Biology, 2012 Macrophage migration inhibitory factor (MIF) is a cytokine which also exhibits enzymatic properties like oxidoreductase and tautomerase. MIF plays a pivotal role in innate and acquired immunity as well as in the neuroendocrine axis.
Nic E. Savaskan +3 more
doaj +1 more source
An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation [PDF]
, 2010 Includes bibliographical references (leaves 134-151).The glucocorticoid receptor (GR) is a ligand-activated transcription factor which, due to its central role in anti-inflammatory responses, is a target of many therapeutically prescribed drugs.
Hadley, Katie Emma
core +1 more source
Selective non-steroidal glucocorticoid receptor agonists attenuate inflammation but do not impair intestinal epithelial cell restitution in vitro [PDF]
, 2012 Introduction: Despite the excellent anti-inflammatory and immunosuppressive action of glucocorticoids (GCs), their use for the treatment of inflammatory bowel disease (IBD) still carries significant risks in terms of frequently occurring severe side ...
Kerstin C Reuter +14 more
core +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer
Endocrine-Related Cancer, 2015 Resistance to docetaxel is a major clinical problem in advanced prostate cancer (PCa). Although glucocorticoids (GCs) are frequently used in combination with docetaxel, it is unclear to what extent GCs and their receptor, the glucocorticoid receptor (GR),
Jan Kroon +13 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Navigating glucocorticoid resistance: From GR isoforms to nuclear condensates
Cell InvestigationGlucocorticoids (GCs) are widely prescribed for their anti-inflammatory and pro-apoptotic effects, mediated primarily through the glucocorticoid receptor (GR).
Chen Wang +5 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns +2 more
wiley +1 more source