Results 21 to 30 of about 3,156,736 (262)

Figure S1 from The Dual Androgen Receptor and Glucocorticoid Receptor Antagonist CB-03-10 as Potential Treatment for Tumors that have Acquired GR-mediated Resistance to AR Blockade

, 2023
<p>Caspase Activity in MDA-MB-231</p>
Mara Gerloni, Luigi Moro, Alessandro Mazzetti, Niccolette Rosette, Frances J. Agan, Caridad Rosette   +5 more
openaire   +1 more source

Supplementary Materials and Methods from The Dual Androgen Receptor and Glucocorticoid Receptor Antagonist CB-03-10 as Potential Treatment for Tumors that have Acquired GR-mediated Resistance to AR Blockade

, 2023
<p>Materials and Methods</p>
Mara Gerloni, Luigi Moro, Alessandro Mazzetti, Niccolette Rosette, Frances J. Agan, Caridad Rosette   +5 more
openaire   +1 more source

Next generation systemic acquired resistance [PDF]

, 2011
Systemic acquired resistance (SAR) is a plant immune response to pathogen attack. Recent evidence suggests that plant immunity involves regulation by chromatin remodeling and DNA methylation.
Luna Diez, Estrella, Victor Flors, Roberts, M. R., Toby J.A. Bruce, Bruce, T. J. A., Roberts, Michael, Jurriaan Ton, Luna, E., Flors, V., Ton, Jurriaan, Luna, Estrella, Estrella Luna, Flors, Victor, Bruce, Toby, Michael R. Roberts, Bruce, Toby J. A., Ton, J.   +16 more
core   +2 more sources

Pharmacokinetics of CB-03-10 from The Dual Androgen Receptor and Glucocorticoid Receptor Antagonist CB-03-10 as Potential Treatment for Tumors that have Acquired GR-mediated Resistance to AR Blockade

, 2023
<p>Pharmacokinetics of CB-03-10</p>
Mara Gerloni, Luigi Moro, Alessandro Mazzetti, Niccolette Rosette, Frances J. Agan, Caridad Rosette   +5 more
openaire   +1 more source

Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring [PDF]

, 1998
Low birth weight in humans is predictive of insulin resistance and diabetes in adult life. The molecular mechanisms underlying this link are unknown but fetal exposure to excess glucocorticoids has been implicated, The fetus is normally protected from ...
Kenyon, C J, Seckl, J R, C J Kenyon, Burchell, A, R S Lindsay, A Burchell, J R Seckl, Lindsay, R S, M J Nyirenda, Nyirenda, M J   +9 more
core   +1 more source

Chronic Stress and Glucocorticoid Receptor Resistance in Asthma.

Clinical Therapeutics, 2020
PURPOSE Chronic and persistent exposure to negative stress can lead to adverse consequences on health. Particularly, psychosocial factors were found to increase the risk and outcome of respiratory diseases like asthma.
María Laura Palumbo, Andrés Prochnik, M. Wald, A. Genaro   +3 more
semanticscholar   +1 more source

Glucocorticoid receptor activation by long acting steroids and its modification by inflammation [PDF]

, 2007
s: Glucocorticoids have an effective anti-inflammatory, anti-proliferative and immunomodulatory activity. Therefore this class of drugs is used worldwide for the treatment of inflammatory diseases and to prevent rejection following organ transplantation.
Yang, Jing-Qing
core   +1 more source

GR Dimerization and the Impact of GR Dimerization on GR Protein Stability and Half-Life

Frontiers in Immunology, 2019
Pharmacologically, glucocorticoids, which mediate their effects via the glucocorticoid receptor (GR), are a most effective therapy for inflammatory diseases despite the fact that chronic use causes side-effects and acquired GC resistance.
Ann Louw
doaj   +1 more source

Mifepristone reduces insulin resistance in patient volunteers with adrenal incidentalomas that secrete low levels of cortisol : a pilot study [PDF]

, 2013
Background: Incidental adrenal masses are commonly detected during imaging for other pathologies. 10% of the elderly population has an ‘adrenal incidentaloma’, up to 20% of these show low-grade autonomous cortisol secretion and 60% of patients with ...
Rita Chadarevian, Eastell, R. (Richard), Richard J Ross, Richard Eastell (153287), Chadarevian, Rita, Debono, M., Newell-Price, John, Rita Chadarevian (399995), Richard J. Ross (399996), Richard Eastell, Randeva, Harpal S., Chadarevian, R., John Newell-Price (399997), Newell-Price, J., Ross, R.J., Miguel Debono (399994), Ross, Richard J. M., Miguel Debono, John Newell-Price, Eastell, R.   +19 more
core   +1 more source

Nonclassic lipoid congenital adrenal hyperplasia masquerading as familial glucocorticoid deficiency [PDF]

, 2009
Context: Familial glucocorticoid deficiency (FGD) is an autosomal recessive disorder resulting from resistance to the action of ACTH on the adrenal cortex.
Racine, M, Naville, D., Nurnberg, G., Green, J, Metherell, L. A., Nurnberg, P, Krone, NP, Krone, N. P., Arlt, W, Tomlinson, Jeremy, Achermann, JC, Halaby, G, Tomlinson, J. W., Clark, A. J. L., Krone, Nils, Naville, D, Berney, D. M., Begeot, M., Huebner, A., Halaby, G., Green, J., Berney, DM, Clark, AJ, Lin, L, Lin, L., Racine, M., Arlt, Wiebke, Achermann, J. C., Arlt, W., Nurnberg, G, Metherell, LA, Tomlinson, JW, Begeot, M, Huebner, A, Nurnberg, P., Clark, AJL   +35 more
core   +1 more source