Results 31 to 40 of about 3,156,736 (262)

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair. [PDF]

Adv Sci (Weinh)
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Souali-Crespo S, Rizk JG, Calvano E, Sahu R, Colovic E, Chabba I, Gilbart V, Grandgirard E, Morlet B, Cai Q, Metzger D, Duteil D.   +11 more
europepmc   +2 more sources

Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2 [PDF]

, 2010
Context: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder as a result of mutation in genes encoding either the ACTH receptor [melanocortin 2 receptor (MC2R)] or its accessory protein [melanocortin 2 receptor accessory ...
Metherell, LA, Chung, TTLL, Clark, AJ, Chung, TT, Chan, LF, Clark, AJL   +5 more
core   +1 more source

Molecular mechanisms contributing to glucocorticoid resistance in lymphoid malignancies

Cancer Drug Resistance, 2019
Despite the introduction of many novel therapies into the clinic to target hematological malignancies, glucocorticoids (GCs) still remain one of the cornerstone drugs in first-line treatment of lymphoid tumors.
B. Scheijen
semanticscholar   +1 more source

Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]

, 1987
Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Strähle, Uwe, Boshart, Michael, Schmid, Wolfgang, Miksicek, Richard, Jansen, Hans-Michael, Gloss, Bernd, Schlitz, Günther, Stewart, Francis   +7 more
core   +1 more source

Abstract A123: Reversal of glucocorticoid resistance in pediatric acute lymphoblastic leukemia is dependent on restoring BIM expression

Drug Resistance and Modifiers, 2019
Introduction: Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Glucocorticoids (e.g. dexamethasone, prednisolone) form a critical component of chemotherapy regimens for pediatric ALL and initial resistance to glucocorticoid ...
R. Lock, C. Toscan, Duo-Hui Jing, C. Mayoh   +3 more
semanticscholar   +1 more source

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Kenyon, C J, Joel K. Elmquist, Elmquist, Joel K., Flier, Jeffrey S., Jonathan R. Seckl, Yamamoto, H, Yamamoto, Hiroshi, Mullins, J J, John J. Mullins, Shinyama, H, Shinyama, Hiroshi, Masuzaki, H, Nicholas M. Morton, Janice M. Paterson, Paterson, Janice M., Sharp, M G F, Jeffrey S. Flier, Seckl, J R, Sharp, Matthew G. F., Masuzaki, Hiroaki, Paterson, J M, Matthew G.F. Sharp, Seckl, Jonathan R., Hiroshi Yamamoto, Morton, Nicholas M., Stewart Fleming, Elmquist, J K, Morton, N M, Hiroaki Masuzaki, Flier, J S, Mullins, John J., Fleming, S, Hiroshi Shinyama, Fleming, Stewart, Kenyon, Christopher J., Christopher J. Kenyon   +35 more
core   +1 more source

Targeting the glucocorticoid receptor signature gene Mono Amine Oxidase-A enhances the efficacy of chemo- and anti-androgen therapy in advanced prostate cancer

Oncogene, 2021
Despite increasing options for treatment of castration-resistant prostate cancer, development of drug resistance is inevitable. The glucocorticoid receptor (GR) is a prime suspect for acquired therapy resistance, as prostate cancer (PCa) cells are able ...
M. Puhr, A. Eigentler, F. Handle, H. Hackl, Christian Ploner, I. Heidegger, G. Schaefer, M. Brandt, J. Hoefer, G. van der Pluijm, H. Klocker   +10 more
semanticscholar   +1 more source

Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain [PDF]

, 2012
Total glucocorticoid hormone levels in plasma of various species, including humans, follow a circadian rhythm that is made up from an underlying series of hormone pulses. In blood most of the glucocorticoid is bound to corticosteroid-binding globulin and
Linthorst, Astrid C E, Droste, Susanne K, Reul, Johannes M H M, Qian, Xiaoxiao, Lightman, Stafford L   +4 more
core   +1 more source

Contribution of Dendritic Cell Responses to Sepsis-Induced Immunosuppression and to Susceptibility to Secondary Pneumonia

Frontiers in Immunology, 2018
Dendritic cells (DCs) are bone marrow derived cells which continuously seed in peripheral tissue. During infection, DCs play an essential interface between innate and adaptive immunity.
Marwan Bouras, Marwan Bouras, Karim Asehnoune, Karim Asehnoune, Antoine Roquilly, Antoine Roquilly   +5 more
doaj   +1 more source

Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1:physiological regulator and pharmacological target for energy partitioning [PDF]

, 2007
The major glucocorticoid in man, cortisol, plays important roles in regulating fuel metabolism, energy partitioning and body fat distribution.
Walker, Brian R
core   +1 more source