Results 11 to 20 of about 3,156,736 (262)

A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants. [PDF]

PLoS Pathogens, 2006
Many biological processes are controlled by intricate networks of transcriptional regulators. With the development of microarray technology, transcriptional changes can be examined at the whole-genome level. However, such analysis often lacks information
Dong Wang, Nita Amornsiripanitch, Xinnian Dong   +2 more
doaj   +2 more sources

Clinical Characteristics and Risk Factors for Mortality in Candidemia: A Retrospective Single-Center Study in China [PDF]

Infection and Drug Resistance
Sihai ZhouXin ZhangKaixuan YuanYong LingJiahuan ZhangBenshun TianXiao ZhangDepartment of Clinical Laboratory, Suzhou Ninth People’s Hospital Affiliated to Soochow University, Suzhou, Jiangsu, 215200, People’s Republic of ChinaDepartment of Hepatobiliary ...
Zhou S, Zhang X, Yuan K, Ling Y, Zhang J, Tian B, Zhang X   +6 more
doaj   +2 more sources

Effect of EPA on Hsp90 and GRα protein expression in multiple myeloma drug-resistant cells

BMC Cancer, 2021
Background Approximately 20% of MM patients harbor glucocorticoid (GC) resistance and are not responsive to therapeutic effect. Chaperoneheat-shock proteins Hsp90 is needed for ligand docking, The imbalance of Hsp90/GRα (glucocorticoid receptor α) may be
Shenghao Wu, Yuemiao Chen, Xueshuang Wang, Shanshan Weng, Wenjin Zhou, Zhen Liu   +5 more
doaj   +1 more source

Association Between NR3C1 Mutations and Glucocorticoid Resistance in Children With Acute Lymphoblastic Leukemia

Frontiers in Pharmacology, 2021
Treatment outcomes in children with acute lymphoblastic leukemia (ALL) have been improved substantially, with a cure rate exceeding 80% using conventional therapy.
Haiyan Liu, Ziping Li, Ziping Li, Fei Qiu, Chunjie Li, Xiaojing Lin, Yingyi He, Maoxiang Qian, Yuanbin Song, Hui Zhang   +9 more
doaj   +1 more source

Monitoring Glucocorticoid Receptor in Plasma-derived Extracellular Vesicles as a Marker of Resistance to Androgen Receptor Signaling Inhibition in Prostate Cancer

Cancer Research Communications, 2023
Disease progression following androgen ablation was shown to be associated with upregulation of the glucocorticoid receptor (GR). Longitudinal monitoring of GR expression in circulating extracellular vesicles (EV) may reflect changes in the tumor cell ...
Emanuela Gentile, A. Hahn, Jian H. Song, A. Hoang, Peter D. A. Shepherd, S. Ramachandran, N. Navone, E. Efstathiou, Mark Titus, P. Corn, Sue-Hwa Lin, Christopher J. Logothetis, T. Panaretakis   +12 more
semanticscholar   +1 more source

Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance–associated protein 1 and provokes high levels of cross‐resistance to glucocorticoids [PDF]

Arthritis & Rheumatism, 2006
AbstractObjectiveTo explore the onset and molecular mechanism of resistance to the antimalarial disease‐modifying antirheumatic drug (DMARD) chloroquine (CQ) in human CEM T cells.MethodsHuman CEM cells were used as an in vitro model system to study the development of CQ resistance by growing cells in stepwise increasing concentrations of CQ.ResultsOver
Oerlemans, Ruud, van der Heijden, Joost, Vink, Josefien, Dijkmans, Ben A C, Kaspers, Gertjan J L, Lems, Willem F, Scheffer, George L, Ifergan, Ilan, Scheper, Rik J, Cloos, Jacqueline, Assaraf, Yehuda G, Jansen, Gerrit   +11 more
openaire   +2 more sources

Reduced expression of glycolate oxidase leads to enhanced disease resistance in rice [PDF]

PeerJ, 2013
Glycolate oxidase (GLO) is a key enzyme in photorespiration, catalyzing the oxidation of glycolate to glyoxylate. Arabidopsis GLO is required for nonhost defense responses to Pseudomonas syringae and for tobacco Pto/AvrPto-mediated defense responses.
Mawsheng Chern, Wei Bai, Xuewei Chen, Patrick E. Canlas, Pamela C. Ronald   +4 more
doaj   +2 more sources

The Role of Immunotherapy in the Treatment of Adrenocortical Carcinoma

Biomedicines, 2021
Adrenocortical carcinoma (ACC) is a rare epithelial neoplasm, with a high tendency for local invasion and distant metastases, with limited treatment options. Surgical treatment is the method of choice.
Izabela Karwacka, Łukasz Obołończyk, Sonia Kaniuka-Jakubowska, Krzysztof Sworczak   +3 more
doaj   +1 more source

MicroRNA-124a contributes to glucocorticoid resistance in acute-on-chronic liver failure by negatively regulating glucocorticoid receptor alpha

Annals of Hepatology, 2020
Introduction and objectives: Glucocorticoid resistance frequently associating with inflammation, may severely compromise the therapeutic effect of glucocorticoids.
Xin Wang, Hongrui Xu, Yadong Wang, Chuan Shen, Luyuan Ma, Caiyan Zhao   +5 more
doaj   +1 more source

Data from The Dual Androgen Receptor and Glucocorticoid Receptor Antagonist CB-03-10 as Potential Treatment for Tumors that have Acquired GR-mediated Resistance to AR Blockade

, 2023
<div>Abstract<p>CB-03–10 (cortexolone 17α-valerate-21-propionate) is a synthetic steroidal compound derived from cortexolone (11-deoxycortisone), an intermediate in cortisol biosynthesis. Characterization of the activity of CB-03-10 and its main related compound CB-03–05 (cortexolone 17α-valerate) included <i>in vitro</i> ...
Mara Gerloni, Luigi Moro, Alessandro Mazzetti, Niccolette Rosette, Frances J. Agan, Caridad Rosette   +5 more
openaire   +1 more source