Results 31 to 40 of about 2,391 (154)

Transforming Growth Factor‐Beta Signaling in Cancer: Therapeutic Implications, Challenges, and Pathways to Progress

MedComm – Oncology, Volume 4, Issue 3, September 2025.
TGF‐β inhibition is emerging as a promising cancer therapy, yet translating laboratory success to bedside implementation has suffered significant setbacks. The associated challenges include adverse drug reactions, inadequate predictive models, and activation of alternative signaling pathways.
Faizah A. Alabi, Izuchukwu F. Okpalanwaka, Adenike Oyegbesan, Ebenezar Okoyeocha, Mariam Oladejo, Sikiru O. Imodoye   +5 more
wiley   +1 more source

SAPHO Syndrome [PDF]

, 2018
SAPHO syndrome is an entity that associates musculoskeletal disorders with dermatological alterations. The most characteristic clinical manifestation of the SAPHO syndrome is pain in the anterior chest wall, due to the involvement of the sternoclavicular
Díaz, José Ángel López, Luna, Sara Alcántara, Rubio, Luis Geniz   +2 more
core   +1 more source

Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration

JOR SPINE, Volume 8, Issue 2, June 2025.
The abnormal lipotoxic condition in nucleus pulposus (NP) cells from advanced‐stage intervertebral disc degeneration (IDD) was identified through untargeted LC/MS metabolomics and magnetic resonance spectroscopy. The palmitic acid accumulation resulted in endoplasmic reticulum stress, mitochondrial damage, lipid droplet accumulation, and senescence of ...
Shuangshuang Tu, Yijun Dong, Chuanfu Li, Mingxin Jiang, Liqun Duan, Wenzhi Zhang, Xi Chen   +6 more
wiley   +1 more source

Impact of Working From Home on the Psychological Well‐Being of 365 European Patients With Rheumatic Diseases During COVID‐19 Pandemic. Results of the REUMAVID Study

Musculoskeletal Care, Volume 23, Issue 2, June 2025.
ABSTRACT Objective To evaluate the impact of home working on the psychological well‐being of European patients with Rheumatic and Musculoskeletal Diseases (RMDs) during the COVID‐19 pandemic. Methods REUMAVID is a cross‐sectional study that collected data through an online survey in seven European countries during the COVID‐19 pandemic: Phase 1 (April ...
Marco Garrido‐Cumbrera, Helena Marzo‐Ortega, José Correa‐Fernández, Laura Christen, Victoria Navarro‐Compán   +4 more
wiley   +1 more source

Prenatal Diagnosis of Proteus Syndrome: About a Case

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Proteus syndrome (PS) is a rare disorder (< 1/1000000), marked by progressive overgrowth commonly impacting the skeleton, skin, adipose tissue, and central nervous system. Clinical criteria were established in 2019. PS arises from a somatic activating variation in the AKT1 gene.
Luana Giovannangeli, Virginie Magry, Florence Jobic, Kahia Messaoudi, Walaa Darwiche, Marianne Perriere, Alexis Billes, Ségolène Delmas Lanta, Alice Masurel, Gilles Morin, Guillaume Jedraszak   +10 more
wiley   +1 more source

Preadult Living Conditions During Sociopolitical Transition in Quebrada Chupacigarro Cemetery (500–400 bc), Supe Valley, Peru: Childhood Morbidity and Sociopolitical Change in Prehistoric Central Andes

International Journal of Osteoarchaeology, Volume 35, Issue 2, March/April 2025.
ABSTRACT Through a detailed assessment of nonspecific stress markers in 67 individuals (47 under 8 years old), this paper investigates the health conditions of preadults in Quebrada Chupacigarro Cemetery (QCC), North‐Central Coast of Peru, during the transition between the Middle and Late Formative periods (500–400 bc), a critical time of ...
Luis Pezo‐Lanfranco, Maria Inés Barreto, José Filippini, Karoline Silva, Aldemar Crispín, Marco Machacuay, Pedro Novoa, Ruth Shady   +7 more
wiley   +1 more source

Pre-Colombian treponemal infection in Denmark - a paleopathological and archaeometric approach [PDF]

, 2013
The aim of this paper is to investigate five new cases of possible treponematosis in early medieval Denmark. A total of 1018 skeletons from Danish and present day German cemeteries have been examined, and five candidates of pre-Columbian individuals have
Rasmussen, Kaare Lund, Schwarz, Susanne, Skytte, Lilian   +2 more
core   +1 more source

Evidence of Pellagra on 19th Century Human Crania From Northern Italy by Combining Stable Isotope and Paleopathological Analyses

International Journal of Osteoarchaeology, Volume 35, Issue 2, March/April 2025.
ABSTRACT Pellagra is a disease caused by a nutritional deficiency, with fatal outcome due to multiple‐organ failure, that affected European rural areas until the early decades of the 20th century, especially Veneto region (Italy). At the skeletal level, previous studies pointed out that pathological signs left by the disease are generic and typical of ...
Nicola Carrara, Gregorio Dal Sasso, Anna Addis, Anna Domanico, Nereo Preto, Elisa Saler, Telmo Pievani, Gilberto Artioli, Cinzia Scaggion   +8 more
wiley   +1 more source

The Genetic Architecture of High Bone Mass [PDF]

, 2020
The phenotypic trait of high bone mass (HBM) is an excellent example of the nexus between common and rare disease genetics. HBM may arise from carriage of many 'high bone mineral density [BMD]'-associated alleles, and certainly the genetic architecture ...
Duncan, Emma L, Gregson, Celia L
core   +2 more sources

Glycerophospholipids: Roles in Cell Trafficking and Associated Inborn Errors

Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.
ABSTRACT Glycerophospholipids (GPLs) are the main lipid components of cellular membranes. They are implicated in membrane structure, vesicle trafficking, neurotransmission, and cell signalling. GPL molecules are amphiphilic, organized around the three carbons of glycerol. Positions sn‐1 and sn‐2 are each esterified to a fatty acid (FA).
Foudil Lamari, Francis Rossignol, Grant A. Mitchell   +2 more
wiley   +1 more source