Results 91 to 100 of about 3,685,138 (295)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Acquired Resistance to Antituberculosis Drugs in England, Wales, and Northern Ireland, 2000–2015
Emerging Infectious Diseases, 2018 Among tuberculosis (TB) patients, acquired resistance to anti-TB drugs represents a failure in the treatment pathway. To improve diagnosis and care for patients with drug-resistant TB, we examined the epidemiology and risk factors associated with ...
Miranda G. Loutet +5 more
doaj +1 more source
Systemic Acquired Resistance [PDF]
The Plant Cell, 1996 J. A., Ryals +5 more
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Genetics of fungal resistance to systemic fungicides [PDF]
, 1977 Since the introduction of the systemic fungicides, fungicide resistance has become a serious problem in plant disease control. This study was carried out in order to contribute to the knowledge about the genetics of fungal resistance to fungicides both ...
Tuyl, J.M., van, van Tuyl, J.M.
core
Frontiers in ImmunologyDelta-like ligand 3 (DLL3) is the first tumor cell surface antigen in small cell lung cancer (SCLC) to support an approved T-cell-redirecting therapy with demonstrated survival benefit, namely the DLL3×CD3 bispecific T-cell engager tarlatamab.
Xitan Wang, Fuli Wang, Wei Tian
doaj +1 more source
Acquired Resistance of Treponema pallidum to Penicillin
Experimental Biology and Medicine, 1946 SummaryThe minimal curative dose of a commercial penicillin in aqueous solution by intramuscular injection 3 times a day for 10 doses in succession was apparently slightly more than 1000 units per kg (totalling 10,000 units) and probably somewhat less than 5000 units per dose (totalling 50,000 units) in the treatment of acute testicular syphilis of ...
J A, KOLMER, A M, RULE
openaire +2 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Increasing Resistance of Nosocomial and Community-Acquired Escherichia coli in Clinical Samples from Hospitals and Clinics in Sana’a City [PDF]
Antimicrobial resistance in Escherichia coli presents a global challenge associated with nosocomial infections and increased mortality rates. Understanding resistance profiles is crucial for guiding treatment strategies and ensuring effective antibiotic ...
Abdulrahman S Bazaid +8 more
core +1 more source