Results 81 to 90 of about 3,685,138 (295)
Identification of the cir1 disease resistance gene in Arabidopsis thaliana [PDF]
, 2012 Includes bibliographical references.Plants rely on an elaborate multi-layered defence system to perceive and effectively respond to disease causing pathogens.
Diener, Anastashia
core +1 more source
Treating EGFR mutation resistance in non-small cell lung cancer – role of osimertinib
The Application of Clinical Genetics, 2017 Valentina Mazza,1 Federico Cappuzzo1,2 1Department of Oncology-Hematology, 2Department of Medical Oncology, AUSL Romagna, Ravenna, Italy Abstract: The discovery of mutations in EGFR significantly changed the treatment paradigm of patients with EGFR ...
Mazza V, Cappuzzo F
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Hospital management of community-acquired pneumonia in Malta [PDF]
, 2012 Community-acquired pneumonia (CAP) remains a common diagnosis requiring hospital admission and a leading cause of death worldwide. No local guideline is currently available for the management of CAP.
Mamo, Jonathan +3 more
core
Non-small cell lung cancer research: advances and persistent challenges
Frontiers in OncologyNon-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, prompting significant advancements in therapeutic and precision medicine.
Lin Zhou, Jiakang Jiang
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Neuroendocrine transdifferentiation in human cancer: molecular mechanisms and therapeutic targets
MedCommNeuroendocrine transdifferentiation (NEtD), also commonly referred to as lineage plasticity, emerges as an acquired resistance mechanism to molecular targeted therapies in multiple cancer types, predominately occurs in metastatic epidermal growth factor ...
Jun Jiang +5 more
doaj +1 more source
CDK4/6 inhibition in cancer: the cell cycle splicing connection
Molecular & Cellular Oncology, 2019 Cyclin-dependent kinase −4 and −6 (CDK4/6) inhibitors are currently being assessed in clinical trials for the treatment of many cancers including melanoma.
Karen E. Sheppard, Shatha AbuHammad
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A comprehensive review of mechanisms underlying resistance to immune checkpoint inhibitors
Frontiers in ImmunologyImmune checkpoint inhibitors (ICIs) have revolutionized the management of multiple malignancies, offering durable clinical benefit in a subset of patients.
Alexandre Bertucci +6 more
doaj +1 more source