Results 11 to 20 of about 3,685,138 (295)

Next-Generation Systemic Acquired Resistance     [PDF]

Plant Physiology, 2011
AbstractSystemic acquired resistance (SAR) is a plant immune response to pathogen attack. Recent evidence suggests that plant immunity involves regulation by chromatin remodeling and DNA methylation. We investigated whether SAR can be inherited epigenetically following disease pressure by Pseudomonas syringae pv tomato DC3000 (PstDC3000).
Luna, E., Bruce, T. J. A., Roberts, M. R., Flors, V., Ton, J.   +4 more
core   +10 more sources

Activity of tarloxotinib‐E in cells with EGFR exon‐20 insertion mutations and mechanisms of acquired resistance

Thoracic Cancer, 2021
Background Approximately 10% of non‐small cell lung cancers (NSCLCs) that harbor epidermal growth factor receptor (EGFR) gene mutations have in‐frame insertions in exon 20 of the EGFR gene.
Masaya Nishino, Kenichi Suda, Takamasa Koga, Shuta Ohara, Toshio Fujino, Junichi Soh, Vijaya Tirunagaru, Avanish Vellanki, Robert C. Doebele, Tetsuya Mitsudomi   +9 more
doaj   +1 more source

Understanding Lineage Plasticity as a Path to Targeted Therapy Failure in EGFR-Mutant Non-small Cell Lung Cancer

Frontiers in Genetics, 2020
Somatic alterations in the epidermal growth factor receptor gene (EGFR) result in aberrant activation of kinase signaling and occur in ∼15% of non-small cell lung cancers (NSCLC).
Tatiana Shaurova, Letian Zhang, David W. Goodrich, Pamela A. Hershberger   +3 more
doaj   +1 more source

Antimicrobial Resistance: Is There a ‘Light’ at the End of the Tunnel?

Antibiotics, 2023
In recent years, with the increases in microorganisms that express a multitude of antimicrobial resistance (AMR) mechanisms, the threat of antimicrobial resistance in the global population has reached critical levels.
Leon G. Leanse, Sanjay Marasini, Carolina dos Anjos, Tianhong Dai   +3 more
doaj   +1 more source

The Central Role of Salivary Metalloproteases in Host Acquired Resistance to Tick Feeding

Frontiers in Cellular and Infection Microbiology, 2020
During feeding on vertebrate hosts, ticks secrete saliva composed of a rich cocktail of bioactive molecules modulating host immune responses. Although most of the proteinaceous fraction of tick saliva is of little immunogenicity, repeated feeding of ...
Jan Perner, Dominic Helm, Per Haberkant, Tereza Hatalova, Sara Kropackova, Jose M. Ribeiro, Petr Kopacek   +6 more
doaj   +1 more source

HSP90 inhibition overcomes EGFR amplification‐induced resistance to third‐generation EGFR‐TKIs

Thoracic Cancer, 2021
Background Patients with non‐small cell lung cancer (NSCLC) harboring activating EGFR mutations are sensitive to epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKIs) but inevitably develop resistance to the inhibitors mostly through ...
Sho Watanabe, Yasushi Goto, Hiroyuki Yasuda, Takashi Kohno, Noriko Motoi, Yuichiro Ohe, Hiroyoshi Nishikawa, Susumu S. Kobayashi, Kazuyoshi Kuwano, Yosuke Togashi   +9 more
doaj   +1 more source

Targeting the EMT transcription factor Snail overcomes resistance to osimertinib in EGFR‐mutant non‐small cell lung cancer

Thoracic Cancer, 2021
Background The resistance mechanism of the third generation of epidermal growth factor (EGFR) tyrosine kinase inhibitor (TKI) osimertinib is complex. Epithelial mesenchymal transition (EMT) is a common mechanism of EGFR‐TKI acquired resistance.
Qiong Qin, Xiaoqing Li, Xingmei Liang, Lili Zeng, Jing Wang, Linlin Sun, Diansheng Zhong   +6 more
doaj   +1 more source

Systemic Acquired Resistance [PDF]

Plant Signaling & Behavior, 2006
Upon infection with necrotizing pathogens many plants develop an enhanced resistance to further pathogen attack also in the uninoculated organs. This type of enhanced resistance is referred to as systemic acquired resistance (SAR). In the SAR state, plants are primed (sensitized) to more quickly and more effectively activate defense responses the ...
openaire   +2 more sources

Acquired resistance mechanisms to immunotherapy [PDF]

Annals of Translational Medicine, 2016
Harnessing the immune system to act against malignant tumors has long been investigated. Recently, checkpoint blockade mechanisms were identified as possible targets to be used in the immunotherapy field.
Teresa, Amaral, Claus, Garbe
openaire   +2 more sources

PRMT5 promotes chemotherapy‐induced neuroendocrine differentiation in NSCLC

Thoracic Cancer, 2023
Background In response to therapeutic treatments, cancer cells can exhibit a variety of resistance phenotypes including neuroendocrine differentiation (NED).
Qi Shen, Yi Liu, Xuehong Deng, Chang‐Deng Hu   +3 more
doaj   +1 more source