Results 21 to 30 of about 3,685,138 (295)

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Naomi Walsh, Martin Clynes, Rizwan Sheikh, Sheikh, Rizwan, O'Connor, Robert A., Robert O’Connor, Ray McDermott, O'Connor, Robert, Clynes, Martin, Walsh, Naomi, McDermott, Ray   +10 more
core   +1 more source

Genetic Basis of Tetracycline Resistance in Bifidobacterium animalis subsp lactis [PDF]

, 2010
All strains of Bifidobacterium animalis subsp. lactis described to date show medium level resistance to tetracycline. Screening of 26 strains from a variety of sources revealed the presence of tet(W) in all isolates. A transposase gene upstream of tet(W)
van Hoek, A.H.A.M., Hoek, A.H.A.M., van, de los Reyes-Gavilan, C.G., Stroman, P., Stuer-Lauridsen, B., Gueimonde, M., Reyes-Gavilan, C.G., de los, Florez, A.B., Margolles, A.   +8 more
core   +1 more source

Acquired Antibiotic Resistance Genes: An Overview [PDF]

Frontiers in Microbiology, 2011
In this review an overview is given on antibiotic resistance (AR) mechanisms with special attentions to the AR genes described so far preceded by a short introduction on the discovery and mode of action of the different classes of antibiotics. As this review is only dealing with acquired resistance, attention is also paid to mobile genetic elements ...
Angela H.A.M. van Hoek, Dik eMevius, Dik eMevius, Beatriz eGuerra, Peter eMullany, Adam Paul Roberts, Henk J.M. Aarts   +6 more
openaire   +5 more sources

Antiviral and quality effects of chemical elictors and Cucumber Mosaic Virus (CMV) infection on tomato plants and fruits [PDF]

, 2012
Cucumber mosaic virus (CMV) has emerged as one of the most serious threats to tomato cultivation in Greece. In the present study the effects of Benzothiadiazoles (BTH) and pyraclostrobin against mechanically or aphid-transmitted CMV in tomato plants ...
Kalogirou, Maria
core   +7 more sources

Statement on how to interpret the QPS qualification on ‘Acquired antimicrobial resistance genes’

EFSA Journal, 2023
The qualified presumption of safety (QPS) approach was developed to provide a regularly updated generic pre‐evaluation of the safety of microorganisms intended for use in the food or feed chains.
EFSA Panel on Biological Hazards (BIOHAZ), Konstantinos Koutsoumanis, Ana Allende, Avelino Álvarez‐Ordóñez, Declan Bolton, Sara Bover‐Cid, Marianne Chemaly, Alessandra De Cesare, Friederike Hilbert, Roland Lindqvist, Maarten Nauta, Romolo Nonno, Luisa Peixe, Giuseppe Ru, Marion Simmons, Panagiotis Skandamis, Elisabetta Suffredini, Pier Sandro Cocconcelli, Juan Evaristo Suárez, Estefanía Noriega Fernández, Frédérique Istace, Jaime Aguillera, Rosella Brozzi, Ernesto Liébana, Beatriz Guerra, Sandra Correia, Lieve Herman   +26 more
doaj   +1 more source

Acquired Resistance to the Shwartzman Phenomenon

Experimental Biology and Medicine, 1951
Summary and conclusions1. The resistance to the Shwartzman phenomenon which develops when the reaction is elicited at short intervals is transient, disappearing after a rest period of 21-28 days. 2. This resistance was found to be effective against Shwartzman active materials from heterologous bacterial species. 3.
L E, CLUFF, I L, BENNET
openaire   +2 more sources

Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance [PDF]

, 2004
Drug-resistant tuberculosis can be transmitted (primary) or develop during the course of treatment (secondary). We investigated risk factors for each type of resistance.
Glynn, JR, Story, A, Hayward, AC, Watson, JM, Conaty, SJ, Drobniewski, FA   +5 more
core   +1 more source

Mutation and Transmission Profiles of Second-Line Drug Resistance in Clinical Isolates of Drug-Resistant Mycobacterium tuberculosis From Hebei Province, China

Frontiers in Microbiology, 2019
The emergence of drug-resistant tuberculosis (TB) is involved in ineffective treatment of TB, especially multidrug resistant/extensively resistant TB (MDR/XDR-TB), leading to acquired resistance and transmission of drug-resistant strains.
Qianlin Li, Huixia Gao, Zhi Zhang, Yueyang Tian, Tengfei Liu, Yuling Wang, Jianhua Lu, Yuzhen Liu, Erhei Dai   +8 more
doaj   +1 more source

Managing Acquired Resistance to Third-Generation EGFR Tyrosine Kinase Inhibitors Through Co-Targeting MEK/ERK Signaling

Lung Cancer: Targets and Therapy, 2021
Danlei Yu,1,2,* Wen Zhao,2,3,* Karin A Vallega,2 Shi-Yong Sun2 1Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Hematology and Medical Oncology, Emory ...
Yu D, Zhao W, Vallega KA, Sun SY
doaj  

Drug Resistance to molecular targeted therapy and its consequences for the treatment decisions in non-small-cell lung cancer

Frontiers in Oncology, 2014
Our ability to detect and directly target the oncogenic alterations responsible for tumor proliferation has contributed significantly to the management of lung cancer in the last decade.
Johanna N Spaans, Glenwood Dillon Goss, Glenwood Dillon Goss, Glenwood Dillon Goss   +3 more
doaj   +1 more source