Results 61 to 70 of about 18,364 (206)

ZAN, IZUMO1, and TMEM95 Protein Domains Identify the Physiological Status of the Sperm

Andrology, EarlyView.
ABSTRACT Background Infertility is a growing concern, which has led to an increase in the use of assisted reproductive techniques, involving in vitro sperm capacitation. Nonetheless, the optimal capacitation time remains a matter of debate, and it is unknown whether it has an impact on the localization of key membrane proteins.
Miranda Hernández‐Falcó, Paula Sáez‐Espinosa, Alejandro Romero, Andrea López‐Botella, Laura Robles‐Gómez, María José Gómez‐Torres   +5 more
wiley   +1 more source

Spatiotemporal Expression of ARRDC5 in Mammalian Spermatogenesis

Andrology, EarlyView.
ABSTRACT Background Spermiogenesis is the final phase of sperm development during which haploid round spermatids transform into specialized spermatozoa and occurs across distinct stages of sperm production in the seminiferous epithelium. Abnormalities in this process lead to malformations and an inability of sperm to fertilize eggs.
LeeLa D. Robinson, Jon M. Oatley
wiley   +1 more source

Male Mice Heterozygous for Protamine 1 and Protamine 2 Are Infertile, Displaying Sperm Damage and Retention of Protamine 2 Precursors, Transition Proteins, and Histones

Andrology, EarlyView.
ABSTRACT Background During spermiogenesis, protamines (PRMs) replace histones to hypercondense and protect sperm DNA. Rodents and primates express two PRMs (PRM1 and PRM2). Alterations of species‐specific PRM ratios are associated with sub‐ or infertility in mice and humans.
Gina Esther Merges, Christoph Wiesejahn, Mar Domingo‐Lopez, Simon Schneider, Andjela Kovacevic, Lena Arévalo, Hubert Schorle   +6 more
wiley   +1 more source

Biallelic Truncating Variant in LRGUK Is Associated With Severe Multiple Morphological Abnormalities of the Sperm Flagella and Sperm Nuclear Defects in Humans

Clinical Genetics, EarlyView.
A homozygous truncating variant in LRGUK results in loss of the LRGUK protein and causes multiple morphological abnormalities of the flagella (MMAF), disrupted axonemal architecture, central pair defects, abnormal chromatin organization, and severe male infertility, establishing LRGUK as a novel human infertility gene.
Wiâme Mokkedem, Zeina Wehbe, Anne‐Laure Barbotin, Angèle Boursier, Célia Tebbakh, Nicolas Thierry‐Mieg, Marie Bidart, Antonella Migliaccio, Rosanna Chianese, Christophe Arnoult, Raoudha Zouari, Zine‐Eddine Kherraf, Pierre F. Ray, Guillaume Martinez, Charles Coutton   +14 more
wiley   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

Motilidade espermática e integridade acrossomal em doses de sêmen suíno refrigeradas e inoculadas com Esecherichia coli e Staphylococcus aureus Sperm motility and acrossomal integrity in liquid boar semen dosis inoculated with Esecherichia coli and Staphylococcus aureus

Ciência Rural, 2000
Foram utilizados 12 ejaculados, coletados de maneira asséptica, distribuídos em sete tratamentos, sendo um grupo controle e os demais inoculados com três diferentes concentrações de S. aureus ou E. coli (5 x 10(5), 5 x 10(6) e 5 x 10(7) UFC/ml).
Paulo Eduardo Bennemann, Fernando Pandolfo Bortolozzo, Ivo Wentz, Marisa Ribeiro de Itapema Cardoso   +3 more
doaj   +1 more source

The Therapeutic Effects of Crocus sativus L. and Its Constituents on the Improving Treatment of Azoospermia: A Narrative Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Azoospermia, defined as the complete absence of sperm in the ejaculate, is a major cause of male infertility and is classified into obstructive and non‐obstructive forms. While obstructive azoospermia is primarily mechanical in origin, non‐obstructive azoospermia (NOA) is characterized by impaired spermatogenesis and is ...
Faraz Khakshour, Melika Hadad Tehran, Jamal Jalili Shahri, Farid Zeynali, Fahimeh Lavi Arab   +4 more
wiley   +1 more source

Dose‐Dependent Effects of Clinoptilolite Supplementation on Sperm Quality and Oxidative Stress During Canine Semen Cryopreservation

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Clinoptilolite supplementation in canine semen extenders showed dose‐dependent effects during cryopreservation, with 2% yielding optimal post‐thaw sperm quality. Higher concentrations impaired sperm parameters, likely due to oxidative imbalance, highlighting the importance of precise dosing to enhance cryosurvival.
Nurdan Coşkun, Fikret Karaca
wiley   +1 more source