Results 121 to 130 of about 1,969 (137)

Sperm Acrosome Biogenesis and Function During Fertilization

2016
Fil: Buffone, Mariano Gabriel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Biologia y Medicina Experimental. Fundacion de Instituto de Biologia y Medicina Experimental.
openaire   +2 more sources

Equatorial segment protein defines a discrete acrosomal subcompartment persisting throughout acrosomal biogenesis.

Biology of reproduction, 2004
The equatorial segment of the acrosome underlies the domain of the sperm that fuses with the egg membrane during fertilization. Equatorial segment protein (ESP), a novel 349-amino acid concanavalin-A-binding protein encoded by a two-exon gene (SP-ESP) located on chromosome 15 at q22, has been localized to the equatorial segment of ejaculated human ...
Michael J, Wolkowicz, Jagathpala, Shetty, Anne, Westbrook, Ken, Klotz, Frederike, Jayes, Arabinda, Mandal, Charles J, Flickinger, John C, Herr   +7 more
openaire   +1 more source

Human acrosome biogenesis: immunodetection of proacrosin in primary spermatocytes and of its partitioning pattern during meiosis

Development, 1991
ABSTRACT Proacrosin biosynthesis timing during human spermatogenesis has been studied using the monoclonal antibody 41)4 (mAb 4D4). Frozen and paraffin-embedded sections of testicular biopsies were labelled by standard indirect immunofluorescence and avidin-biotin immunoperoxidase procedures.
D, Escalier, J M, Gallo, M, Albert, G, Meduri, D, Bermudez, G, David, J, Schrevel   +6 more
openaire   +2 more sources

Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice.

Biology of reproduction, 2012
An omega-3 fatty acid, docosahexaenoic acid (DHA), is enriched in testicular membrane phospholipids, but its function is not well understood. The Fads2 gene encodes an enzyme required for the endogenous synthesis of DHA. Using Fads2-null mice (Fads2-/-), we found in our preceding studies that DHA deficiency caused the arrest of spermiogenesis and male ...
Manuel, Roqueta-Rivera, Timothy L, Abbott, Mayandi, Sivaguru, Rex A, Hess, Manabu T, Nakamura   +4 more
openaire   +2 more sources

Actin-related protein T3 is required for acrosome biogenesis and sperm function in mice

Development
ABSTRACT Actin-related protein T3 (ACTRT3) is localized in the perinuclear theca (PT) of murine spermatids. We generated Actrt3−/− male mice and showed that they are subfertile, with defects of the acrosome first observed during cap phase.
Andjela Kovacevic, Eva Ordziniak, Naila Umer, Lena Arevalo, Leo D. Hinterlang, Sanaz Ziaeipour, Sara Suvilla, Gina E. Merges, Hubert Schorle   +8 more
openaire   +3 more sources

Acrosome biogenesis and perinuclear theca defects in globozoospermia

Fertility and Sterility, 2012
C. Alvarez Sedó, G. Alvarez, V.Y. Rawe, H. Chemes   +3 more
openaire   +1 more source

Relationship between UBPy and the Endosome System in Acrosome Biogenesis

2009
Summary. One of the major events that characterize spermiogenenesis is the formation of the acrosome. Acrosome-less spermatozoa are infertile; in human, globozoospermia is a rare but severe disorder in male infertility. The acrosome formation is far more complicated than has been so far proposed.
openaire   +1 more source

C-terminal kinesin motor KIFC1 participates in acrosome biogenesis and vesicle transport.

Biology of reproduction, 2004
We have identified a possible role for the KIFC1 motor protein in formation of the acrosome, an organelle unique to spermatogenesis. KIFC1, a C-terminal kinesin motor, first appears on membrane-bounded organelles (MBOs) in the medulla of early spermatids followed by localization to the acrosomal vesicle. KIFC1 continues to be present on the acrosome of
Wan-Xi, Yang, Ann O, Sperry
openaire   +1 more source

Human globozoospermia‐related genes and their role in acrosome biogenesis

WIREs Mechanisms of Disease, 2023
Ricardo D Moreno
exaly  

IZUMO family member 3, IZUMO3, is involved in male fertility through the acrosome formation

Molecular Reproduction and Development, 2021
Naokazu Inoue, Yuhkoh Satouh, Ikuo Wada   +2 more
exaly