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SIRT1 haploinsufficiency recapitulates age-associated subfertility through sperm α-tubulin hyperacetylation. [PDF]

Biol Direct
Iniesta-Cuerda M, Valentova I, Moravec J, Liška F, Králíčková M, Krapf D, Nevoral J.   +6 more
europepmc   +1 more source

Autophagy-Related Proteins Influence Mouse Epididymal Sperm Motility. [PDF]

Int J Mol Sci
Rodríguez-Páez L, Magaña JJ, Aguirre-Alvarado C, Alcántara-Farfán V, Chamorro-Cevallos G, Cristóbal-Luna JM, Rosales-Cruz E, Reyes-Maldonado E, Jiménez-Gutiérrez GE, Cordero-Martínez J.   +9 more
europepmc   +1 more source

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Equatorin is not essential for acrosome biogenesis but is required for the acrosome reaction

Biochemical and Biophysical Research Communications, 2014
The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in mammalian fertilization. However, the regulatory mechanisms controlling acrosome biogenesis and acrosome exocytosis during fertilization are largely unknown.
Shaoyang Ji, Yaqing Wang, Xingxu Huang   +2 more
exaly   +3 more sources

Human globozoospermia‐related genes and their role in acrosome biogenesis

WIREs Mechanisms of Disease, 2022
AbstractThe mammalian acrosome is a secretory vesicle attached to the sperm nucleus whose fusion with the overlying plasma membrane is required to achieve fertilization. Acrosome biogenesis starts during meiosis, but it lasts through the entire process of haploid cell differentiation (spermiogenesis).
openaire   +3 more sources

The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice

2022
Abstract The acrosome is a membranous organelle positioned in the anterior portion of sperm head and is essential for male fertility. Acrosome biogenesis requires the dynamic cytoskeletal shuttling of vesicles towards nascent acrosome which is regulated by a series of accessory proteins.
Ke Xu, Xianwei Su, Kailun Fang, Yue Lv, Gang Lu, Waiyee Chan, Zi-Jiang Chen, Jinlong Ma, Hongbin Liu   +8 more
openaire   +1 more source

RAB2A: a major subacrosomal protein of bovine spermatozoa implicated in acrosomal biogenesis.

Biology of reproduction, 2008
The perinuclear theca (PT) of mammalian sperm is a unique subcellular structure encapsulating the nucleus. Compositionally, the PT is made up of at least six prominent polypeptides (60, 36, 31, 28, 24, and 15 kDa), of which only two have been sequence identified, as well as many less prominent ones.
Jeremi R, Mountjoy, Wei, Xu, Dave, McLeod, David, Hyndman, Richard, Oko   +4 more
openaire   +2 more sources