Results 91 to 100 of about 5,280,557 (249)

Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration

Andrology, EarlyView.
ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda, Jiřina Havránková, Hedvika Řimnáčová, Jiří Moravec, František Liška, Martin Knytl, Milena Králíčková, Jan Nevoral   +7 more
wiley   +1 more source

Capacitation of mouse sperm is modulated by gamma-aminobutyric acid (GABA) concentration

The Journal of Reproduction and Development, 2019
In mammals, ejaculated sperm acquire their fertilizing ability during migration through the female reproductive tract, which secretes several factors that contribute to sperm capacitation.
Shouhei KURATA, Yuuki HIRADATE, Kohei UMEZU, Kenshiro HARA, Kentaro TANEMURA   +4 more
doaj   +1 more source

Impact of Chemotherapy on Sperm Functional Characteristics in Patients With Testicular Germ Cell Tumours

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCT) are the most common malignancies among young men and represent a major threat to reproductive health. Both the disease itself and oncological treatments, particularly chemotherapy, can compromise spermatogenesis and semen quality.
Ondrej Sanovec, Ondrej Simonik, Zuzana Kratka, Lukas Ded, Jana Vondrakova, Maryam Qasemi, Barbora Bryndova, Michala Krejci, Daniela Spevakova, Vishma Pratap Sur, Radomir Kren, Tomas Hradec, Pavel Skrobanek, Ludmila Boublikova, Libor Zamecnik, Tomas Buchler, Jiri Neuzil, Pavla Postlerova, Katerina Komrskova   +18 more
wiley   +1 more source

Expression, localization and functions in acrosome reaction and sperm motility of Ca(V)3.1 and Ca(V)3.2 channels in sperm cells: an evaluation from Ca(V)3.1 and Ca(V)3.2 deficient mice.: Cav3.1/3.2 channel functions in sperm physiology [PDF]

, 2007
International audienceIn spermatozoa, voltage-dependent calcium channels (VDCC) have been involved in different cellular functions like acrosome reaction (AR) and sperm motility. Multiple types of VDCC are present and their relative contribution is still
Arnoult, Christophe, Boisseau, Sylvie, Campbell, Kevin,, Chen, Chien-Chang, de Waard, Michel, Escoffier, Jessica, Kim, Daesoo, Serres, Catherine, Shin, Hee-Sup, Stamboulian, Séverine   +9 more
core   +3 more sources

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, EarlyView.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Acrosome reaction in morphologically different types of human spermatozoa

Zdravniški Vestnik, 2011
Background: The aim of our study was to ascertain if the acrosome functionality differs between various morphological types of spermatozoa in human. Methods: Fourteen ejaculates were resuspended in the culture medium with the aim to wash the spermatozoa ...
Mojca Čižek Sajko, Borut Kovačič, Veljko Vlaisavljević   +2 more
doaj  

Possible Role of N-Methyl-D-Aspartate Glutamate Receptors in The Induction of Acrosome Reaction in Human Sperm [PDF]

Cell Journal
Objective: Acrosome reaction is a receptor and Ca2+-dependent process. N-Methyl-D- aspartate (NMDA) glutamatereceptors are expressed in the human sperm and are involved in the Ca2+ influx.
Hamid Reza Momeni, Elham Farjad, Abolghasem Naiemi, Tahereh Etemadi, Mohammad Hussein Abnosi, Niloufar Darbandi   +5 more
doaj   +1 more source

Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization [PDF]

, 2015
Background: Fertilization is a key physiological process for the preservation of the species. Consequently, different mechanisms affecting the sperm and the oocyte have been developed to ensure a successful fertilization. Thus, sperm acrosome reaction is
Avilés Sánchez, Manuel, Bernabeu, Rafael, García Hernández, Eva María, Gil-Izquierdo, Ángel, González-Brusi, Leopoldo, Guerrero, Jaime, Gómez-Torres, María José, Izquierdo-Rico, María José, Medina, Sonia, Orduna, Jesús, Savirón, María, Ten Morro, Jorge   +11 more
core   +2 more sources

Mechanism of sperm capacitation and the acrosome reaction: role of protein kinases.

Asian Journal of Andrology, 2012
Mammalian sperm must undergo a series of biochemical and physiological modifications, collectively called capacitation, in the female reproductive tract prior to the acrosome reaction (AR). The mechanisms of these modifications are not well characterized
D. Ickowicz, Maya Finkelstein, H. Breitbart   +2 more
semanticscholar   +1 more source

Testis‐Enriched F‐Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice

Andrology, EarlyView.
ABSTRACT Background The SCF (Skp–Cullin–F‐box) complex is a major class of E3 ubiquitin ligases. F‐box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F‐box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes.
Yuki Kaneda, Haruhiko Miyata, Masahito Ikawa   +2 more
wiley   +1 more source