Results 71 to 80 of about 2,059,461 (220)

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

open access: yesThe FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari   +7 more
wiley   +1 more source

Calcium ionophore A23187 versus progesterone: induction of acrosome reaction in thawed and prepared cryopreserved semen samples [PDF]

open access: yes
Background: Acrosome reaction facilitates fertilization and it can be induced in-vitro using various stimuli like progesterone, calcium ionophore A23187, prostaglandins, etc.
Arunkumar, Sowbarnika   +2 more
core   +1 more source

Capacitation of mouse sperm is modulated by gamma-aminobutyric acid (GABA) concentration

open access: yesThe Journal of Reproduction and Development, 2019
In mammals, ejaculated sperm acquire their fertilizing ability during migration through the female reproductive tract, which secretes several factors that contribute to sperm capacitation.
Shouhei KURATA   +4 more
doaj   +1 more source

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington   +4 more
wiley   +1 more source

Regulation of the Acrosome Reaction by the Transmembrane Adenylyl Cyclase

open access: yes
REGULATION OF THE ACROSOME REACTION BY THE TRANSMEMBRANE ADENYLYL CYCLASE SEPTEMBER 2012 DOUGLAS HADDAD, B.S., UNIVERSITY OF MASSACHUSETTS AMHERST M.Sc., UNIVERSITY OF MASSACHUSETTS AMHERST Directed by: Pablo Visconti Capacitation prepares mammalian ...
Haddad, Douglas M
core   +1 more source

Studies on male infertility--acrosome reaction of the human sperm incubated in vitro [PDF]

open access: yes, 1985
triple-stain techniqueを用いヒト精子acrosome reactionを観察した.1) mBWW中では培養6時間後まではacrosome reaction陽性精子の割合は漸増した.2) human serum albuminを含まない培養液中ではacrosome reactionはおこらなかった.Caイオン, Ca ionophore A23187, trypsinにはacrosome reactionの誘発作用を認めた.3)不妊患者精子の中で乏精子症患者の精子や運動率が20 ...
岡田, 弘
core  

Possible Role of N-Methyl-D-Aspartate Glutamate Receptors in The Induction of Acrosome Reaction in Human Sperm [PDF]

open access: yesCell Journal
Objective: Acrosome reaction is a receptor and Ca2+-dependent process. N-Methyl-D- aspartate (NMDA) glutamatereceptors are expressed in the human sperm and are involved in the Ca2+ influx.
Hamid Reza Momeni   +5 more
doaj   +1 more source

Synergistic Effects of Thyroxine and Nano‐Melatonin on Post‐Thaw Sperm Quality, Antioxidant Defence and Fertility of Cryopreserved Simmental Bull Semen

open access: yesVeterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Effects of thyroxine (T) and nano‐melatonin (NM) supplementation on cryopreserved Simmental bull semen were evaluated. The combination of thyroxine (0.5 µg/dL) and nano‐melatonin (30 µg/dL) significantly improved post‐thaw sperm motility, membrane integrity, antioxidant status, and fertility while reducing oxidative stress and apoptosis. These findings
Marwa Abonagy   +18 more
wiley   +1 more source

Regulation of the sperm EGF receptor by ouabain leads to initiation of the acrosome reaction [PDF]

open access: yes, 2010
The sperm acrosome reaction occurs after the binding of the capacitated sperm to the egg zona pellucida. This study describes a novel mode of regulation of the sperm epidermal growth factor receptor (EGFR) under physiological conditions and its relevance
Rubinstein, Sara   +5 more
core   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

open access: yesBiological Reviews, Volume 101, Issue 5, Page 2265-2278, October 2026.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido   +2 more
wiley   +1 more source

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