Results 81 to 90 of about 13,944 (183)

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Epididymosome‐Supplemented Extender Induces Changes in Morpho‐Functional Traits and microRNA Levels of Post‐Thaw Sperm and Improves Embryo Developmental Potential

Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT While molecular signature contributes to sperm quality and fertility potential, sperm may lost key molecules during cryopreservation. Since sperm cells are transcriptionally inert and rely on interactions with epididymosomes (epEVs) to acquire molecules, herein, we investigated the effects of the addition of epEVs to the cryopreservation ...
Laura Gabrielli Haupenthal, Maria Alice de Almeida, Cibele Maria Prado, Amanda Nespolo Silva, Gabriela Melendes Schneider, Paola Maria da Silva Rosa, Flávio Vieira Meirelles, Juliano Coelho da Silveira, Felipe Perecin, Maíra Bianchi Rodrigues Alves   +9 more
wiley   +1 more source

Effect of acrosome reaction progress in frozen-thawed boar spermatozoa on the efficiency of in vitro oocyte fertilization

Veterinární Medicína, 2010
A good functional status of cryopreserved boar spermatozoa is very important for successful fertilization of porcine oocytes and in vitro embryo production.
S. Martecikova, P. Hulinska, Z. Reckova, A. Pavlik, M. Jeseta, M. Machatkova   +5 more
doaj   +1 more source

Mussel Spermatozoa Express a Specific Isoform of the Catalytic Subunit of cAMP‐Dependent Protein Kinase

Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT cAMP‐dependent protein kinase (PKA) plays a central role in regulating sperm motility in both invertebrates and mammals. The sea mussel Mytilus galloprovincialis provides a valuable model for investigating the molecular mechanisms underlying gamete activation in externally fertilizing organisms.
Izaskun Ibarguren, Saskia‐Camille Flament‐Simon, Ana P. Losada, Susana. B. Bravo, José Antonio Villamarín   +4 more
wiley   +1 more source

Elevated LncRNA LINC00966 Suppresses PDE2A to Impair Sperm Motility in Asthenozoospermia

FASEB BioAdvances, Volume 8, Issue 8, August 2026.
This study identifies LINC00966 as an upregulated lncRNA in asthenozoospermia associated with reduced sperm quality. Linc00966 suppresses Pde2a, disrupts cGMP signaling, and promotes oxidative stress, thereby impairing spermatogenic cell viability and migration.
Bingrou Guo, Junyi Ke, Hanran Mai, Ting Zhang, Zhaojin Lu, Zilin Zheng, Jieyi Luo, Yifan Zhang, Mei Yan, Shuo Yang, Yanxia Qu, Fan Jiang, Xiaoping Liu, Hao Chen, Liandong Zuo   +14 more
wiley   +1 more source

Evaluation of Oxidative Profiling in Semen Fractions and Its Relationship With Sperm Function in Kangal Akkaraman Rams

Reproduction in Domestic Animals, Volume 61, Issue 8, August 2026.
ABSTRACT The determination of sperm oxidative stress provides significant information related to semen quality. Most studies investigate oxidative stress markers only at the level of seminal plasma, but this approach may provide an incomplete overview of the oxidative status of semen.
Abdulkadir Kaya, Omer Varisli, Ali Senol, Haceli Ocal, Hamide Taskin, Bora Ozarslan   +5 more
wiley   +1 more source

NUCB2/nesfatin-1 suppresses the acrosome reaction in sperm within the mouse epididymis. [PDF]

Anim Cells Syst (Seoul), 2023
Kim S, Sun S, Kim M, Ha J, Seok E, Yang H.   +5 more
europepmc   +1 more source

Effects of pentoxifylline treatment before freezing on motility, viability and acrosome status of poor quality human spermatozoa cryopreserved by the liquid nitrogen vapor method

Brazilian Journal of Medical and Biological Research, 2007
The objective of the present study was to investigate the effects of the direct addition of pentoxifylline (PF) to the ejaculates of men with poor sperm quality before freezing on post-thaw sperm motility, viability, acrosome integrity, and agonist ...
S.C. Esteves, D.M. Spaine, A.P. Cedenho
doaj  

Deep Learning-Based Precision Analysis for Acrosome Reaction by Modification of Plasma Membrane in Boar Sperm. [PDF]

Animals (Basel), 2023
Park M, Yoon H, Kang BH, Lee H, An J, Lee T, Cheong HT, Lee SH.   +7 more
europepmc   +1 more source

The human acrosome reaction.

Asian journal of andrology, 2001
We developed tests of sperm-oocyte interaction: sperm-zona binding, zona-induced acrosome reaction, spermzona penetration and sperm-oolemma binding, using oocytes which failed to fertilise in clinical in vitro fertilization (IVF). Although oocyte defects contribute to failure of sperm oocyte interaction, rarely are all oocytes from one woman affected ...
H W, Baker, D Y, Liu, C, Garrett, M, Martic   +3 more
openaire   +1 more source