Results 111 to 120 of about 154,811 (301)

Acrylamide in health and disease

Frontiers in Bioscience, 2011
Acrylamide has been classified as a probable carcinogen and can be ingested, inhaled (e.g. tobacco smoke), or absorbed. Fried, starchy foods are the most prominent sources of exposure. The reaction between asparagine and fructose typically produces the most acrylamide in foods from plant sources.
Kaci N, Pruser, Nick E, Flynn
openaire   +2 more sources

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Genetic and agronomic approaches to decreasing acrylamide precursors in crop plants [PDF]

, 2007
Progress in developing genetic and agronomic approaches for reducing the levels of the principal precursors of acrylamide, asparagine and sugars in crop plants is reviewed. The factors that affect asparagine and sugar accumulation, particularly in cereal
Halford, Nigel G., Muttucumaru, Nira, Parry, Martin A.J., Parry, M. A J, Parry, M. A. J., Halford, N. G., Curtis, Tanya Y., Curtis, T. Y., Muttucumaru, N., Parry, Martin, Halford, Nigel   +10 more
core   +1 more source

Heat‐Suppressing Projection Two‐Photon Lithography Enables High‐Throughput Sub‐Micrometer Manufacturing of Biopolymer Hydrogels for Tissue Engineering

Advanced Science, EarlyView.
The iLEAP technique integrates high‐throughput two‐photon lithography with extrusion printing, bridging sub‐micrometer precision and macroscopic scaffold fabrication. By employing a low‐exothermic photoinitiator, it mitigates thermal damage to biopolymers and preserves bioactivity.
Qifeng Guan, Yanzhe Fu, Xiangyu Xu, Naitao Li, Sen Hou, Kai Wang, Yufan Wang, Jiakun Li, Ping Li, Jiebo Li, Lizhen Wang, Yubo Fan   +11 more
wiley   +1 more source

Acrylamide in cereals: the problem, and potential genetic and agronomic solutions

, 2016
This chapter focuses on the problems associated with the presence of acrylamide in various crops, such as potatoes, wheat and rye, among others, and the risks represented by the dietary intake of acrylamide at the levels present in ...
T. Y. Curtis, N. G. Halford, Halford, N. G., Curtis, T. Y., Halford, Nigel, Curtis, Tanya   +5 more
core   +1 more source

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

Phosphatidylcholine protects against the hepatotoxicity of acrylamide via maintaining metabolic homeostasis of glutathione and glycerophospholipid

Food Science and Human Wellness
Acrylamide is classified as a Class 2A carcinogen and mainly metabolized to produce hepatotoxicity. Phosphatidylcholine is thought to protect the liver from damage, but the protective role of phosphatidylcholine on acrylamide-exposed metabolic disorders ...
Yaoran Li, Wei Jia, Yiju Zhang, Yong Wu, Li Zhu, Jingjing Jiao, Yu Zhang   +6 more
doaj   +1 more source

Root‐Inspired Microneedle Patch With Interlocked Rigid‐Soft Architecture for High Tissue‐Adaptiveness

Advanced Science, EarlyView.
A root‐inspired microneedle array patch uses lattice‐based mechanical interlocking to unite rigid microneedles with a flexible substrate. The interlocked rigid–soft architecture improves interfacial bonding, supports stable adhesion on curved and wet tissues under dynamic motion, and provides a versatile platform for robust biointerfacing and future ...
Jongchan Lee, Yeongjun Song, Yonghyun Cho, Hyo In Kim, Dong‐Hyun Youn, Jinbong Park, Seungbeom Choi, Dohyun Kwon, Brian Jun Lee, Sangyul Baik   +9 more
wiley   +1 more source

Association of Cyp2e1, Gst and Meh Genetic Polymorphisms with Urinary Acrylamide Metabolites in Workers Exposed to Acrylamide

, 2012
This study elucidates the association of acrylamide metabolites, N-acetyl -S-(2-carbamoylethyl)-cysteine (AAMA), N-acetyl-S-(1-carbamoyl-2- hydroxyethyl)-cysteine (GAMA2), and N-acetyl-S-(2-carbamoyl-2-hydroxyethyl )-cysteine (GAMA3) in urine with ...
HUANG, YU-FANG;CHEN, MEI-LIEN;LIOU, SAOU-HSING;UANG, SHI-NIAN;WU, KUEN-YUH, 黃郁芳;陳美蓮;劉紹興;汪禧年;吳焜裕   +1 more
core   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source