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Optimized iCIEF Fractionation Enables Deep Profiling of Antibody Drug Conjugate Charge Heterogeneity

ELECTROPHORESIS, EarlyView.
This study developed and optimized an iCIEF fractionation method to characterize ADC charge variants. The optimized approach enabled stable separation, identification of major PTMs, and drug‐load distributions across light and heavy chains. ABSTRACT Antibody drug conjugates (ADCs) are a novel class of therapeutic drugs that combine selectivity of an ...
Eunju Jang, Qunying Zhang, Paul M. Thomas   +2 more
wiley   +1 more source

Effect of Ultrasonic Waves and Other Technological Treatments on the Reduction of Acrylamide and Glycoalkaloids in Frozen Prefried Potatoes. [PDF]

Int J Food Sci
Vargas-Finaflor PG, Obispo-Gavino EO, Contreras-Liza SE, Acha DMH, Macavilca EA, Cruz AGYS, Lozada-Urbano M.   +6 more
europepmc   +1 more source

Reducing acrylamide in bread with plant additives: a systematic review. [PDF]

Food Chem X
Abedini A, Salimi M, Zargaraan A, Sadighara P, Sani MA, Mortazavian AM, Mohammadi A.   +6 more
europepmc   +1 more source

Cannabidiol as a Neuroprotective Agent in Acrylamide-Induced Neurotoxicity: Effects on Oxidative Stress, Inflammation, and Cholinergic Function in Male Mice. [PDF]

J Neurosci Res
Atsopardi K, Mesiakaris K, Sotiropoulos I, Margarity M, Poulas K.   +4 more
europepmc   +1 more source

Optimization and Characterization of P(EDOT-<i>co</i>-Th)-Incorporated Poly(acrylamide)/Poly(vinyl alcohol) Conductive Hydrogels. [PDF]

Micromachines (Basel)
Huang KW, Wang CH, Lin CY, Chakravarthy RD, Liu HY, Chen YH, Yeh MY, Lin HC.   +7 more
europepmc   +1 more source

A degradable PEGDA-dopamine hydrogel with ROS scavenging capacity supports flexible design for nerve repair. [PDF]

Mater Today Bio
Huang L, Lu TY, Berman E, Park A, Ercegovac K, Schimelman J, Chen S.   +6 more
europepmc   +1 more source

Quality and chemical safety of wheat bread enriched with untreated, milled, and <i>Lactiplantibacillus plantarum</i> fermented red lentils (<i>Lens culinaris</i> L.). [PDF]

Food Chem X
Starkute V, Bartkiene E, Mockus E, Radvila E, Matuzeviciute D, Balynaite K, Bredikis A, Ilgunaite G, Juskaite A, Cho V, Rocha JM, Cernauskas D, Ruibys R, Mozuriene E, Akin M, Curtis T, Klupsaite D.   +16 more
europepmc   +1 more source

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Acrylamide neurotoxicity

Nutritional Neuroscience, 2013
Acrylamide, a food contaminant, belongs to a large class of structurally similar toxic chemicals, 'type-2 alkenes', to which humans are widely exposed. Besides, occupational exposure to acrylamide has received wide attention through the last decades.
Pinar, Erkekoglu, Terken, Baydar
openaire   +2 more sources