Results 81 to 90 of about 8,172 (292)

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

Straightforward Access to Polyfunctionalized δ-Lactams via Domino Aza–Michael/Thia–Michael/Aldol Sequence

Molecules
Domino reactions are powerful tools for the straightforward synthesis of complex molecules with a particular emphasis on functionalized azacycles. We report a contribution in this field, implemented via a new thia–Michael/aldol sequence between readily ...
Axelle Genty, Ismail Alahyen, Marie-José Tranchant, Jérôme Lhoste, Vincent Dalla, Catherine Taillier, Sébastien Comesse   +6 more
doaj   +1 more source

Thermoresponsive polymer micropatterns fabricated by dip-pen nanolithography for a highly controllable substrate with potential cellular applications [PDF]

, 2016
We report a novel approach for patterning thermoresponsive hydrogels based on N,N-diethylacrylamide (DEAAm) and bifunctional Jeffamine ED-600 by dip-pen nanolithography (DPN). The direct writing of micron-sized thermoresponsive polymer spots was achieved
Carol-Anne Smith, Dimitrios A. Lamprou, Duncan Graham, Flory P. J., Karen Faulds, Matthew J. Dalby, Raffaella Suriano, Samuel Mabbott, Stacey Laing, Stiles P. L.   +9 more
core   +3 more sources

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Photopolymerizable monomer formulations for nanoporous proton conducting membranes [PDF]

, 2011
Several monomers and crosslinker in a broad range of concentrations in water and 1-Methyl-2-pyrrolidone (NMP) respectively were screened for their mechanical properties, water uptake and conductivity by photo polymerization with a polar photo initiator ...
Kellner, M., Liska, R., Matović, Jovan, Radovanović, Filip   +3 more
core   +1 more source

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source

Liver and mucous secretion enzymatic biomarkers of Eobania vermiculata treated with some newly synthesized acrylamide derivatives

Journal of Basic and Applied Zoology
Background Acrylamide derivatives have a potential biological activity as well as acting as precursors in many organic syntheses. Moreover, acrylamides and their derivatives cause convulsions and diffused damage to different sections of the nervous ...
Esam M. Emara, Maher A. El-Sawaf, Rasha F. Khalifa   +2 more
doaj   +1 more source

Flexible Dielectric Acoustic Resonator Patch for Tissue Regeneration

Advanced Materials, EarlyView.
A flexible dielectric acoustic resonator patch enables MHz‐range ultrasound generation through resonance amplification without using piezoelectric materials. Conformal integration on a curved substrate allows efficient acoustic delivery to tissue‐mimicking environments.
Donyoung Kang, Byeongseok Ryu, Sujeong Ahn, Junhyub Kim, Myeonghun Jang, Jeong Ho Cho, Won‐Gun Koh, Hyungsuk Lee   +7 more
wiley   +1 more source

Absolut “copper catalyzation perfected”; robust living polymerization of NIPAM : Guinness is good for SET-LRP [PDF]

The controlled polymerization of N-isopropyl acrylamide (NIPAM) is reported in a range of international beers, wine, ciders and spirits utilizing Cu(0)-mediated living radical polymerization (SET-LRP).
Anastasaki, Athina, Becer, C. Remzi, Burns, James (James Adam), Collins, J. (Jennifer), Droesbeke, Martjin, Girault, Mony, Godfrey, Jamie, Haddleton, Alice J., Haddleton, David M., Houben, Claudia, Kiviaho, Jenny K., Li, Muxiu, Li, Zaidong, Lloyd, Danielle J., McEwan, Kayleigh A., McHale, Ronan, Nikolaou, Vasiliki, Nurumbetov, Gabit, Randev, Rajan, Risangud, Nuttapol, Simula, Alexandre, Summers, Christopher J., Waldron, Christopher, Wilson, Paul, Yilmaz, Gokhan, Zhang, Qiang   +25 more
core   +1 more source

Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis

Advanced Materials, EarlyView.
Eutectozymes are sustainable hybrid materials that embed a GOx–HRP cascade within hydrophobic eutectogels featuring a dual supramolecular–covalent network. This architecture preserves native enzyme structure and stability, enables efficient heterogeneous biocatalysis in aqueous media, and positions eutectogels as robust platforms for next‐generation ...
Manuel Eduardo Martinez Cartagena, Lucia Suarez, Aitor Ontoria, Francisca J. Benitez, Elixabete Rezabal, María Soledad Orellano, Marcelo Calderón, Cristián Huck‐Iriart, Agustin S. Picco, Matias L. Picchio, Ana Beloqui   +10 more
wiley   +1 more source