Results 141 to 150 of about 213,915 (375)

Pro-opiomelanocortin and ACTH–cortisol dissociation during pediatric cardiac surgery

Endocrine Connections
In critically ill adults, high plasma cortisol in the face of low ACTH coincides with high pro-opiomelanocortin (POMC) levels. Glucocorticoids further lower ACTH without affecting POMC.
Arno Téblick, Ilse Vanhorebeek, Inge Derese, An Jacobs, Renata Haghedooren, Sofie Maebe, Gerdien A Zeilmaker-Roest, Enno D Wildschut, Lies Langouche, Greet Van den Berghe   +9 more
doaj   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Cortisol Regulates PD-1 and IL-12 in Canine Leishmaniasis. [PDF]

Parasite Immunol
ABSTRACT Canine visceral leishmaniasis (CanL) is a tropical zoonosis caused by Brazil's protozoan Leishmania (L.) infantum. Disorders in the hypothalamic–pituitary–adrenal (HPA) axis have been reported in human and experimental visceral leishmaniasis, but not yet in canine leishmaniasis.
Ito LTS, Umino GM, Guimarães MA, de Souza BMM, Soares SF, Pereira LEAL, de Lima VMF.   +6 more
europepmc   +2 more sources

Clinical Practice Patterns in Bone Health Assessment and Management in Endogenous Cushing's Syndrome

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Skeletal fragility is a common complication of endogenous Cushing's Syndrome (CS), although specific guidelines for managing bone health are lacking. This study aimed to assess clinicians' current engagement with bone health assessment and management in patients with endogenous CS. Design Retrospective‐cohort design. Patients Seventy‐
Preeshila Behary, Dinushan Raveendran, Ramesh Nair, Aimee Di Marco, Debbie Papadopoulou, Florian Wernig, Ali Abbara, Karim Meeran, Niamh Martin, Jeremy Cox, Alexander N. Comninos   +10 more
wiley   +1 more source

Patients With Pituitary Neuroendocrine Tumours Requiring Neurosurgery –Who Is Referring Them?

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Patients living with pituitary neuroendocrine tumours (PitNETs) present with a spectrum of clinical manifestations and often follow a circuitous route to diagnosis, resulting in diagnostic delays. The objective of this study is to identify and report the various sources of referrals for patients who underwent pituitary resection for ...
Doua S. Ahmed, Brian Herron, Stephen Cooke, Philip Weir, Jane Evanson, Estelle G. Healy, Karen R. Mullan, Stephanie G. Craig, Jacqueline A. James, Márta Korbonits, Steven J. Hunter, Paul Benjamin Loughrey   +11 more
wiley   +1 more source

Cortisol and ACTH responses to severe asphyxia in preterm fetal sheep [PDF]

, 2005
Vincent Roelfsema, Alistair J. Gunn, Mhoyra Fraser, Josine Quaedackers, Laura Bennet   +4 more
openalex   +1 more source

ACTH Stimulation Testing Is Often Unnecessary After Appropriate Patient Preparation Prior to Screening Cortisol Measurement

Clinical Endocrinology, EarlyView.
ABSTRACT Context Screening morning serum cortisol is used to select patients for ACTH stimulation testing to diagnose adrenal insufficiency (AI) but may be affected by pre‐analytical factors. Careful consideration to discontinue confounding medications beforehand may preclude the need for subsequent stimulation testing.
Christopher J. Symonds, Alexander A. Leung, Gregory A. Kline   +2 more
wiley   +1 more source

Ectopic Cushing Syndrome Due to ACTH Secreting Atypic Thymic Carcinoid Tumor [PDF]

, 2016
Cevdet Duran, Meryem Eren Karanis, Süleyman Bakdık, Uysaler Aslan, Mustafa Çalık, Mustafa Çalık   +5 more
openalex   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

ACTH Stimulation Tests for the Diagnosis of Adrenal Insufficiency: Systematic Review and Meta-Analysis.

Journal of Clinical Endocrinology and Metabolism, 2016
N. Ospina, Alaa Al Nofal, I. Bancos, A. Javed, Khalid Benkhadra, Ekta Kapoor, A. Lteif, N. Natt, M. Murad   +8 more
semanticscholar   +1 more source