Results 11 to 20 of about 123,237 (299)

Decreased steroidogenic enzyme activity in benign adrenocortical tumors is more pronounced in bilateral lesions as determined by steroid profiling in LC-MS/MS during ACTH stimulation test

Endocrine Connections, 2022
Objective: Large response of steroid precursors, including 17-hydroxyprogesterone, to adrenocorticotropic hormone (ACTH) has been described in adrenocortical tumors, suggesting the existence of intra-tumoral enzymatic deficiencies.
Fidéline Bonnet-Serrano, Maxime Barat, Anna Vaczlavik, Anne Jouinot, Lucas Bouys, Christelle Laguillier-Morizot, Corinne Zientek, Catherine Simonneau, Etienne Larger, Laurence Guignat, Lionel Groussin, Guillaume Assié, Jean Guibourdenche, Ioannis Nicolis, Marie-Claude Menet, Jérôme Bertherat   +15 more
doaj   +1 more source

Evaluation of hemolysis interference and possible protective effect of N-phenyl maleimide on the measurement of small peptides

Türk Biyokimya Dergisi, 2022
This study aims to demonstrate that proteolytic enzymes released as a result of hemolysis decrease the small peptide hormones, whereas N-phenyl maleimide (NPM) can be used to prevent hemolysis interference.
Durmaz Mustafa, Erguder Imge
doaj   +1 more source

ACTH more than 2000 pg/ml; is it immunoassay interference or another matter?

Journal of Pathology of Nepal, 2023
Starting rifampicin in patients with Addison’s disease or adrenal tuberculosis may precipitate an adrenal crisis as a result of the induction of CYP 3A4 which in turn leads to increased breakdown of cortisol.
Vivek Pant, Santosh Pradhan
doaj   +1 more source

Arx expansion mutation perturbs cortical development by augmenting apoptosis without activating innate immunity in a mouse model of X-linked infantile spasms syndrome

Disease Models & Mechanisms, 2020
X-linked infantile spasms syndrome (ISSX) is a clinically devastating developmental epileptic encephalopathy with life-long impact. Arx(GCG)10+7, a mouse model of the most common triplet-repeat expansion mutation of ARX, exhibits neonatal spasms ...
Meagan S. Siehr, Cory A. Massey, Jeffrey L. Noebels   +2 more
doaj   +1 more source

Laporan kasus berbasis bukti: Efektivitas Kortikosteroid dalam Pengobatan Spasme Infantil

Sari Pediatri, 2022
Latar belakang. Spasme infantil (SI) adalah suatu sindrom epilepsi berat dengan awitan masa bayi. Hormon adrenokortikotropik(ACTH) merupakan obat utama pada SI.
Teti Hendrayani, Masayu Rita, Syarif Darwin, Raden Muhammad Indra   +3 more
doaj   +1 more source

Plasma ACTH, α-MSH and cortisol variations in the dog during the oestrous cycle in different photoperiods

Veterinární Medicína, 2015
The hypothalamic-pituitary-adrenal axis (HPA) is a complex system regulated by multiple factors. Sexual dimorphism of this axis has been described in different species under physiological conditions and it has been proposed that sexual hormones could ...
M.F. Gallelli, N. Monachesi, D.D. Miceli, M.F. Cabrera Blatter, N.V. Gomez, A. Meikle, V.A. Castillo   +6 more
doaj   +1 more source

ACTH: The forgotten therapy.

Seminars in Immunology, 2015
Although anti-inflammatory drugs are among the most common class of marketed drugs, chronic inflammatory conditions such as rheumatoid arthritis, multiple sclerosis or inflammatory bowel disease still represent unmet needs. New first-in-class drugs might
T. Montero-Melendez
semanticscholar   +1 more source

Changes in plasma ACTH levels and corticotroph tumor size in patients with Cushing's disease during long-term treatment with the glucocorticoid receptor antagonist mifepristone.

Journal of Clinical Endocrinology and Metabolism, 2014
CONTEXT Pituitary effects of long-term therapy with mifepristone, a glucocorticoid receptor antagonist, in Cushing's disease (CD) patients are not well understood.
M. Fleseriu, J. Findling, C. Koch, S. Schlaffer, M. Buchfelder, Coleman Gross   +5 more
semanticscholar   +1 more source

Adrenal dysfunction in critical care settings

Journal of Pediatric Critical Care, 2017
Adrenal insufficiency (AI) is a frequently discussed but inadequately understood condition among critically ill patients. Increased glucocorticoid action is an essential component of the stress response.
Vinayak Patki, Praveen Khilnani, Jerry Zimmerman   +2 more
doaj   +1 more source

Predictive Factors of Adrenal Insufficiency in Outpatients with Indeterminate Serum Cortisol Levels: A Retrospective Study

Medicina, 2020
Background and Objectives: To diagnose adrenal insufficiency (AI), adrenocorticotropic hormone (ACTH) stimulation tests may need to be performed, but those tests may not be available in some institutions.
Worapaka Manosroi, Mattabhorn Phimphilai, Jiraporn Khorana, Pichitchai Atthakomol, Tanyong Pipanmekaporn   +4 more
doaj   +1 more source