بررسی اثر تداخل عمل استرس بیحرکتی با نیکوتین بر عملکرد محور هیپوفیز-آدرنال در موشهای صحرایی نر بالغ [PDF]
زمینه و هدف: نیکوتین آلکالوئیدی است که از طریق مصرف سیگار مورد استفاده میلیونها نفر در دنیا میباشد، این افراد همزمان در معرض انواعی از استرسزاها قرار دارند که اثراتی را بر بدن، از جمله سیستمهای اندوکرین دارد.
سید ابراهیم حسینی
doaj
HYPERPIGMENTATION AND ACTH – AN OVERVIEW OF LITERATURE [PDF]
Introduction. ACTH (adrenocorticotropic hormone) is a key regulator of adrenal production involving cortisol as an essential hormone for life. The melanin is a pigment which is produced by melanocytes at the level of melanosomes (the melanogenesis ...
Florica Sandru +4 more
doaj +1 more source
Impact of Gene-Gender Effects of Adrenergic Polymorphisms on Hypothalamic-Pituitary-Adrenal Axis Activity in Depressed Patients [PDF]
Objective: There is overwhelming evidence that activation of the hypothalamic-pituitary-adrenal (HPA) system plays a major role in depression and cardiovascular disease in genetically susceptible individuals.
Baghai, Thomas C. +7 more
core +1 more source
Nancy Ho-Mahler,1 Beni Turner,2 Michael Eaddy,2 Mark L Hanke,1 Winnie W Nelson1 1Mallinckrodt Pharmaceuticals, Bedminster, NJ, USA; 2Xcenda, Palm Harbor, FL, USACorrespondence: Nancy Ho-MahlerMallinckrodt Pharmaceuticals, 1425 U.S. Route 206, Bedminster,
Ho-Mahler N +4 more
doaj
The Influence of Hyperactivity of the Hypothalamic-pituitary-adrenal Axis and Hyperglycemia on the 5-HT2A Receptor-mediated Wet-dog Shake Responses in Rats [PDF]
Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis induces hyperglycemia and serotonin (5-HT)2A receptor supersensitivity. In the present study, to investigate the effect of hyperglycemia on the function of 5-HT2A receptors, we compared the 5-
Amano, Manabu +7 more
core +1 more source
Developmental Outcomes of Infants Treated With Combination Therapy for Infantile Spasms
The International Collaborative Infantile Spasms Study (ICISS) Group evaluated the developmental and epilepsy outcomes at 18 months following hormonal treatment alone or hormonal treatment combined with vigabatrin.
Jacqueline Wolak, Sunita N Misra
doaj +1 more source
A case of cushing syndrome of undetermined cause managed medically with cabergoline
We report a 77 year old lady with hypertension and hypokalaemic metabolic alkalosis who was found to have ACTH dependant Cushing Syndrome (CS). Cortisol level was not suppressed during low dose as well as high dose dexamethazone suppression test (HDDST).
Muneer Ahmad +1 more
doaj +1 more source
This is a case report of 59 years old male with adrenocorticotropic hormone ACTH-independent macronodular adrenal hyperplasia (AIMAH), which is a rare cause of Cushing's syndrome. He was detected to have adrenal lesions incidentally on imaging.
Yashendu Sarda +4 more
doaj +1 more source
Nonhypnotic low-dose etomidate for rapid correction of hypercortisolaemia in cushing's syndrome [PDF]
We determined the adrenostatic potential of low-dose nonhypnotic etomidate in six patients with Cushing's syndrome (ectopic Cushing's syndrome,n=2; Cushing's disease,n=3; bilateral adrenal adenoma,n=1). Etomidate was given as a continuous infusion for 32
Allolio, B. +5 more
core +1 more source
DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su +16 more
wiley +1 more source

