Developmental Outcomes of Infants Treated With Combination Therapy for Infantile Spasms
Pediatric Neurology Briefs, 2019 The International Collaborative Infantile Spasms Study (ICISS) Group evaluated the developmental and epilepsy outcomes at 18 months following hormonal treatment alone or hormonal treatment combined with vigabatrin.
Jacqueline Wolak, Sunita N Misra
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, 2011 Bioluminescence resonance energy transfer analysis is used to study the interaction between melanocortin 2 receptor (MC2R) accessory protein and the MC2R and provides evidence for protein kinase A-dependent conformational changes in the receptor complex ...
Adrian J. L. Clark +9 more
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A case of cushing syndrome of undetermined cause managed medically with cabergoline
Sri Lanka Journal of Medicine, 2018 We report a 77 year old lady with hypertension and hypokalaemic metabolic alkalosis who was found to have ACTH dependant Cushing Syndrome (CS). Cortisol level was not suppressed during low dose as well as high dose dexamethazone suppression test (HDDST).
Muneer Ahmad +1 more
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Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia [PDF]
, 2007 Objective Familial glucocorticoid deficiency type I (FGD1) is a rare form of primary adrenal insufficiency resulting from recessive mutations in the ACTH receptor (MC2R, MC2R).
Hindmarsh, PC +9 more
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Journal of Family Medicine and Primary Care, 2020 This is a case report of 59 years old male with adrenocorticotropic hormone ACTH-independent macronodular adrenal hyperplasia (AIMAH), which is a rare cause of Cushing's syndrome. He was detected to have adrenal lesions incidentally on imaging.
Yashendu Sarda +4 more
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Effect of ACTH on the Proliferation of the Rat Adrenal Gland
, 2003 2003-12Although the regulation of steroidogenesis in adrenal fasciculate and reticularis is stimulated by adrenocorticotrophic hormone (ACTH), its role on the proliferation of adrenocortical call is not established.
Seo, Hisao +4 more
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New Cut-off Value for Low-Dose Acth Stimulation Test in the Diagnosis of Adrenal Insufficiency
, 2023 Aim:Although the peak cortisol response in the low-dose test does not reach the generally accepted value of 18 μg/dL, there are many patients whose adrenal insufficiency diagnosis was ruled out by getting an adequate response with the standard-dose test.
M. Masum Canat +2 more
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Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
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Immune checkpoint inhibitor induced hypophysitis: a specific disease of corticotrophs?
Endocrine ConnectionsIntroduction: The aim of this study was to define functional and anatomical pituitary disease at the time of presentation following immune checkpoint inhibitor (ICI) therapy and to describe any changes in pituitary function over time.
Nishchil Patel +6 more
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Molecular interpretation of ACTH-β-endorphin coaggregation: relevance to secretory granule biogenesis. [PDF]
PLoS ONE, 2012 Peptide/protein hormones could be stored as non-toxic amyloid-like structures in pituitary secretory granules. ACTH and β-endorphin are two of the important peptide hormones that get co-stored in the pituitary secretory granules. Here, we study molecular
Srivastav Ranganathan +5 more
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