Results 41 to 50 of about 129,829 (283)

Immune checkpoint inhibitor induced hypophysitis: a specific disease of corticotrophs?

Endocrine Connections
Introduction: The aim of this study was to define functional and anatomical pituitary disease at the time of presentation following immune checkpoint inhibitor (ICI) therapy and to describe any changes in pituitary function over time.
Nishchil Patel, Kagabo Hirwa, Gemma Gardner, Kirsten Pearce, Jinny Jeffery, Fizzah Iqbal, Daniel Flanagan   +6 more
doaj   +1 more source

Molecular interpretation of ACTH-β-endorphin coaggregation: relevance to secretory granule biogenesis. [PDF]

PLoS ONE, 2012
Peptide/protein hormones could be stored as non-toxic amyloid-like structures in pituitary secretory granules. ACTH and β-endorphin are two of the important peptide hormones that get co-stored in the pituitary secretory granules. Here, we study molecular
Srivastav Ranganathan, Pradeep K Singh, Uday Singh, Praful S Singru, Ranjith Padinhateeri, Samir K Maji   +5 more
doaj   +1 more source

Nitric oxide donation lowers blood pressure in adrenocorticotrophic hormone-induced hypertensive rats.

, 2004
Adrenocorticotrophic hormone (ACTH) elevates systolic blood pressure (SBP) and lowers plasma reactive nitrogen intermediates in rats. We assessed the ability of NO donation from isosorbide dinitrate (ISDN) to prevent or reverse the hypertension caused by
Andrews, Miles C, McKenzie, Katja US, Schyvens, Christopher G, Whitworth, Judith A, Zhang, Yi   +4 more
core   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Metabolic complications of endogenous Cushing: patient selection for screening

Ожирение и метаболизм, 2013
Aims: this study evaluates the most common associations of symptoms and complications in patients with Cushing’s syndrome (CS) in order to choose a potential population to be screened for CS and estimates the diagnostic accuracy of first line screening ...

doaj   +1 more source

Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]

, 2011
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Koch, Alexander, Hamann, Lutz, Schott, Matthias, Boehm, Olaf, Grotemeyer, Dirk, Kurt, Muhammed, Schwenke, Carsten, Schumann, Ralf R., Bornstein, Stefan R., Zacharowski, Kai   +9 more
core   +1 more source

Rational Design of Ni3+‐Rich Nickel Nitride Enables Paired Electrooxidation of Sterol and Hydrogen Evolution in a Flow Electrolyzer

Advanced Science, EarlyView.
The rational design of Ni3+‐rich active sites on nickel nitride nanosheets via Pd‐induced electronic modulation, which was employed in the electrooxidation of sterol coupled with H2 production in a large flow electrolyzer. This work offers a novel strategy for the design and synthesis of highly efficient electrocatalysts and electrolyzers toward the ...
Suiqin Li, Jieyu Wang, Ge Feng, Jiahui He, Kai Li, Lihao Liu, Yuhang Wang, Zixian Jia, Yanfei Xu, Wenwu Zhong, Xing Zhong, Jianguo Wang   +11 more
wiley   +1 more source

Cerebrospinal fluid rhinorrhea as a complication of ACTH-secreting pituitary macroadenoma in a patient with morbid obesity

Ожирение и метаболизм, 2014
Cushing's disease (CD) is a progressive neuroendocrine disease caused by a pituitary tumor producing excessive amounts of ACTH. In most cases (80-85%) the cause of the disease is a pituitary corticotroph microadenomas (located within the sella, measuring
Dar'ya Viktorovna Petrova, Laris Konstantinovna Dzeranova, Andrey Yurievich Grigoriev, Oksana Vladimirovna Ivashchenko, Anastasia Mikhailovna Lapshina, Aleksandr Valerievich Vorontsov   +5 more
doaj   +1 more source

From Multiple Congenital Anomalies to Pituitary Gland Malformation: Wide Spectrum of Clinical Features in a Family With FOXA2 Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT FOXA2 (hepatocyte nuclear factor‐3β, HNF‐3β) encodes a transcriptional activator involved in early embryogenesis, particularly in the patterning and differentiation of midline structures such as the neural tube, foregut, and pituitary gland. Its role in human pathogenesis was first suspected when patients with deletion of chromosome 20p11.2 ...
Christopher Connolly, Hemant A. Parmar, Lauren Hipp, Tomoyasu Higashimoto   +3 more
wiley   +1 more source

Development of Adrenocorticotrophic Hormone Cells of Adenohypophysis–Adrenal Cortex Axis of Long-tailed Monkey (Macaca fascicularis) during Pre and Postnatal Period

Jurnal Kedokteran Hewan, 2008
The objective of this study is to observe the relationship of development of adrenocorticotropic hormone (ACTH) cells of adenohypophysis–adrenal cortex axis during pre and postnatal period of longtailed monkey (Macaca fascicularis). Five fetuses aged 70,
Nurhidayat Nurhidayat, Ika K. Syarifah, Supratikno Supratikno, Sri Wahyuni   +3 more
doaj   +1 more source