Results 121 to 130 of about 1,498,374 (404)

Actin in development

Mechanisms of Development, 2003
1. From molecules to morphologyMetazoan development is often viewed as a series ofinformation processing events in which the genomecomputes where and when to synthesize particular geneproducts. Importantly, development is also a feat ofengineering in which genetic information is used to changecell shape and cell–cell interactions to generate form ...
Jacinto, Antonio, Baum, Buzz
openaire   +2 more sources

Activator-inhibitor coupling between Rho signaling and actin assembly make the cell cortex an excitable medium

Nature Cell Biology, 2015
Animal cell cytokinesis results from patterned activation of the small GTPase Rho, which directs assembly of actomyosin in the equatorial cortex. Cytokinesis is restricted to a portion of the cell cycle following anaphase onset in which the cortex is ...
W. Bement, M. Leda, Alison Moe, A. Kita, Matthew E. Larson, A. Golding, Courtney Pfeuti, Kuan-Chung Su, Ann L. Miller, A. Goryachev, G. von Dassow   +10 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

eLife, 2015
Mitochondrial division, essential for survival in mammals, is enhanced by an inter-organellar process involving ER tubules encircling and constricting mitochondria.
U. Manor, S. Bartholomew, Gonen Golani, E. Christenson, M. Kozlov, H. Higgs, J. Spudich, J. Lippincott-Schwartz   +7 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Actin dynamics switches two distinct modes of endosomal fusion in yolk sac visceral endoderm cells

eLife
Membranes undergo various patterns of deformation during vesicle fusion, but how this membrane deformation is regulated and contributes to fusion remains unknown.
Seiichi Koike, Masashi Tachikawa, Motosuke Tsutsumi, Takuya Okada, Tomomi Nemoto, Kazuko Keino-Masu, Masayuki Masu   +6 more
doaj   +1 more source

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton*

Journal of Biological Chemistry, 1998
The tight junction protein ZO-1 belongs to a family of multidomain proteins known as the membrane-associated guanylate kinase homologs (MAGUKs). ZO-1 has been demonstrated to interact with the transmembrane protein occludin, a second tight junction ...
A. Fanning, Brian J. Jameson, L. Jesaitis, James M. Anderson   +3 more
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Steric regulation of tandem calponin homology domain actin-binding affinity. [PDF]

, 2019
Tandem calponin homology (CH1-CH2) domains are common actin-binding domains in proteins that interact with and organize the actin cytoskeleton. Despite regions of high sequence similarity, CH1-CH2 domains can have remarkably different actin-binding ...
Bausch, Andreas, Belardi, Brian, Fletcher, Daniel A, Harris, Andrew R, Jreij, Pamela, Shams, Hengameh, Wei, Kathy   +6 more
core   +1 more source

MLL regulates the actin cytoskeleton and cell migration by stabilising Rho GTPases via the expression of RhoGDI1 [PDF]

, 2022
Akash Chinchole, Kaisar Ahmad Lone, Shweta Tyagi   +2 more
openalex   +1 more source