Results 101 to 110 of about 1,007,443 (313)

F-actin-Cell001-Cell004

, 2023
 20-time points of structured illumination microscopy F-actin data 
XiaoDong Tang (15310825)
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Fundamental differences

eLife, 2018
The differences between β- and γ-actin are deeper than those between the amino acid sequences of these two proteins.
Peter W Gunning, Edna C Hardeman
doaj   +1 more source

Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity

Frontiers in Cellular Neuroscience, 2020
Willin/FRMD6 is part of a family of proteins with a 4.1 ezrin-radixin-moesin (FERM) domain. It has been identified as an upstream activator of the Hippo pathway and, when aberrant in its expression, is associated with human diseases and disorders.
Nils M. Kronenberg, Nils M. Kronenberg, Andrew Tilston-Lunel, Andrew Tilston-Lunel, Frances E. Thompson, Doris Chen, Wanjia Yu, Kishan Dholakia, Kishan Dholakia, Malte C. Gather, Malte C. Gather, Frank J. Gunn-Moore   +11 more
doaj   +1 more source

Actin

1We present the concept of actin networks, which serve as intracellularframeworks, actuator systems, and pathways for information transferand processing within ...
Tuszyński, Jack, Adamatzky, Andrew, Schnauß, Jörg   +2 more
core   +1 more source

Effects of post-translational modifications catalysed by pollen transglutaminase on the functional properties of microtubules and actin filaments [PDF]

, 2009
TGases (transglutaminases) are a class of calcium-dependent enzymes that catalyse the interactions between acyl acceptor glutamyl residues and amine donors, potentially making crosslinks between proteins.
Del, Duca, Cresti, M, Cai, G, Serafini-Fracassini, D, Bonner, PLR   +4 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons

eLife, 2014
In the vertebrate central nervous system, exploratory filopodia transiently form on dendritic branches to sample the neuronal environment and initiate new trans-neuronal contacts.
Milos Galic, Feng-Chiao Tsai, Sean R Collins, Maja Matis, Samuel Bandara, Tobias Meyer   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Vitamin D Binding Protein: A Historic Overview

Frontiers in Endocrinology, 2020
Vitamin D and all its metabolites are bound to a specific vitamin D binding protein, DBP. This protein was originally first discovered by its worldwide polymorphism and called Group-specific Component (GC).
Roger Bouillon, Frans Schuit, Leen Antonio, Leen Antonio, Fraydoon Rastinejad   +4 more
doaj   +1 more source