Results 121 to 130 of about 1,019,729 (309)

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. [PDF]

, 2010
In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan.
Soppo, Charlotte Blanche Ekalle, Martin Klingenspor, Eugenio Scanziani, Hrabě de Angelis, M., Fabrizio Bianchi, Di Fiore, Pier Paolo, B. Pozzi, Offenhäuser Nina, Martin Hrabé de Angelis, Klingenspor Martin, B. Rathkolb, Horsch Marion, Horsch, Marion, Rathkolb, B., Nicole Ehrhardt, Wolf Eckhard, V. Gailus Durner, Tacchetti Carlo, Beckers, Johannes, Jan Rozman, Gailus-Durner, Valérie, Ralf Elvert, Hrabé de Angelis, Martin, Wolf, E., Ehrhardt, Nicole, Johannes Beckers, Elvert, Ralf, Tocchetti, Arianna, Pier Paolo Di Fiore, F. Bianchi, Elvert, R., A. Tocchetti, Horsch, M., Klingenspor, Martin, Bianchi, F., Moerth Corinna, Carlo Tacchetti, Ehrhardt Nicole, Pozzi, Benedetta, Scanziani Eugenio, Gagliani, M.C., Offenhäuser, N., Bianchi Fabrizio, Giorgio Scita, Birgit Rathkolb, M. C. Gagliani, Ehrhardt, N., Scita, G., Fuchs, Helmut, di Fiore, P.P., J. Beckers, Zani Fabio, Corinna Moerth, Eckhard Wolf, de Angelis Martin Hrabé, Mörth, C., Pozzi, B., Fuchs Helmut, M. Klingenspor, Beckers Johannes, M. Horsch, Tacchetti, C., Nina Offenhäuser, Rathkolb, Birgit, G. Scita, Tacchetti, Carlo, Bianchi, Fabrizio, Rozman, J., Rozman, Jan, Maria Cristina Gagliani, Charlotte Blanche Ekalle Soppo, Arianna Tocchetti, Ekalle Soppo Charlotte Blanche, Zani, F., N. Ehrhardt, Fuchs, H., J. Rozman, P.P. Di Fiore, Soppo, C.B.E., Valérie Gailus-Durner, Gailus-Durner, V., Gagliani, Maria Cristina, Moerth, Corinna, E. Scanziani, Scanziani, Eugenio, Helmut Fuchs, N. Offenhäuser, C. Tacchetti, Offenhäuser, Nina, Scita, Giorgio, Fabio Zani, C. Moerth, E. Wolf, Tocchetti, A., Elvert Ralf, Di Fiore Pier Paolo, M. Hrabé de Angelis, Tocchetti Arianna, Beckers, J., F. Zani, C. B. Soppo, Gagliani Maria Cristina, Scita Giorgio, Zani, Fabio, Scanziani, E., Klingenspor, M., Rathkolb Birgit, R. Elvert, Marion Horsch, Benedetta Pozzi, Pozzi Benedetta, Gailus-Durner Valérie, Wolf, Eckhard, Rozman Jan, H. Fuchs, Tocchetti, A., Soppo, C.B.E., Zani, F., Bianchi, F., Gagliani, M.C., Pozzi, B., Rozman, J., Elvert, R., Ehrhardt, N., Rathkolb, B., Moerth, C., Horsch, M., Fuchs, H., Gailus-Durner, V., Beckers, J., Klingenspor, M., Wolf, E., De Angelis, M.H., Scanziani, E., Tacchetti, C., Scita, G., Di Fiore, P.P., Offenhäuser, N., Tocchetti, A. ; Soppo, C.B.E. ; Zani, F. ; Bianchi, F. ; Gagliani, M.C. ; Pozzi, B. ; Rozman, J. ; Elvert, R. ; Ehrhardt, N. ; Rathkolb, B. ; Mörth, C. ; Horsch, M. ; Fuchs, H. ; Gailus-Durner, V. ; Beckers, J. ; Klingenspor, M. ; Wolf, E. ; Hrabé de Angelis, M. ; Scanziani, E. ; Tacchetti, C. ; Scita, G. ; di Fiore, P.P. ; Offenhäuser, N.   +116 more
core   +2 more sources

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Flexible polymer-induced condensation and bundle formation of DNA and F-actin filaments [PDF]

, 2001
A simple semi-empirical theory is developed for the ionic strength dependence of the flexible polymer-induced condensation of semiflexible polyelectrolytes such as DNA and F-actin filaments.
Vries, R., de
core  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Effects of insulin and actin on phosphofructokinase activity and cellular distribution in skeletal muscle

Anais da Academia Brasileira de Ciências, 2004
In this work, we report evidences that the association of phosphofructokinase and F-actin can be affected by insulin stimulation in rabbit skeletal muscle homogenates and that this association can be a mechanism of phos-phofructokinase regulation ...
Silva Ana Paula P., Alves Gutemberg G., Araújo Alexandre H.B., Sola-Penna Mauro   +3 more
doaj  

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source