Results 81 to 90 of about 1,291,235 (309)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Shape Changes of Self-Assembled Actin Bilayer Composite Membranes

, 1997
We report the self-assembly of thin actin shells beneath the membranes of giant vesicles. Ion-carrier mediated influx of Mg2+ induces actin polymerization in the initially spherical vesicles.
B. Alberts, D. S. Dimitrov, E. A. Evans, E. Sackmann, H. Hotani, J. D. Pardee, J. Käs, J. Käs, J. Käs, L. Miao, M. Bärmann, M. Elbaum, M. Schindl, M. W. Deem, R. Grimm, R. Lipowsky, R. Lipowsky, S. Kaufmann, S. MacLean-Fletcher, S. Milner, U. Seifert, W. Häckl, W. Häckl   +22 more
core   +1 more source

Mechanics of bundled semiflexible polymer networks [PDF]

, 2007
While actin bundles are used by living cells for structural fortification, the microscopic origin of the elasticity of bundled networks is not understood.
Bausch, A. R., Claessens, M. M. A. E., Frey, E., Heussinger, C., Lieleg, O.   +4 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Occurrence and a possible mechanism of penetration of natural killer cells into k562 target cells during the cytotoxic interaction [PDF]

, 1995
The cytotoxic interaction between cloned human Natural Killer (NK) cells and K562 target cells was studied using confocal laser scanning microscopy (CLSM) and conventional fluorescence microscopy.
de Grooth, B.G., Figdor, Carl, Greve, Jan, Radosevic, K., Radosevic, Katarina, Segers-Nolten, Gezina M.J., van Leeuwen, Anne Marie T.   +6 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

DISC1 is needed for the organization of cellular components at the immunological synapse. [PDF]

, 2019
T-cells carry out their immune functions through receptor-based recognition and adhesion to target cells. The cell-cell junction that is created from this connection is known as the immunological synapse (IS); a cellular structure composed of organized ...
Ramakrishnan, Adarsh
core   +1 more source

Actin cytoskeleton: Thinking globally, actin’ locally [PDF]

Current Biology, 2000
A class of proteins dubbed pipmodulins bind to and sequester the phospholipid PIP2 in the plasma membrane. Local release of PIP2 controls actin dynamics in specific subcellular regions and plays a critical role in regulating actin-based cell motility and morphogenesis.
Lanier, Lorene M., Gertler, Frank
openaire   +3 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Plasma membrane calcium ATPase activity is regulated by actin oligomers through direct interaction [PDF]

, 2013
As recently described by our group, plasma membrane calcium ATPase (PMCA) activity can be regulated by the actin cytoskeleton. In this study, we characterize the interaction of purified G-actin with isolated PMCA and examine the effect of G-actin during ...
Dalghi, Marianela Gisela, Fernández, Marisa Mariel, Ferreira Gomes, Mariela Soledad, Malchiodi, Emilio Luis, Mangialavori, Irene Cecilia, Rossi, Juan Pablo Francisco, Strehler, Emanuel E.   +6 more
core   +1 more source