Results 61 to 70 of about 1,007,443 (313)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

High Actin Expression in Thrombus of Acute Ischemic Stroke Can Be a Biomarker of Atherothrombotic Origin Stroke

Frontiers in Neurology, 2022
BackgroundAs the treatment target, the imaging information and histologic characteristics of the thrombus may differ according to the stroke subtype.
Rongyu Wang, Zhiqiang Wang, Zhiqiang Wang, Lianyan Jiang, Gangfeng Gu, Bo Zheng, Liulin Xian, Yaodan Zhang, Jian Wang   +8 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Actin at cell-cell junctions is composed of two dynamic and functional populations [PDF]

, 2005
The ability of epithelial cells to polarize requires cell-cell adhesion mediated by cadherin receptors. During cell-cell contact, the mechanism via which a flat, spread cell shape is changed into a tall, cuboidal epithelial morphology is not known.
Erasmus, J., Zeikos, K., Braga, V.M.M., Betson, M., Bailly, M., Cramer, L.P., Zhang, J.   +6 more
core  

Regulation of nuclear actin levels and MRTF/SRF target gene expression during PC6.3 cell differentiation [PDF]

, 2022
Actin has important functions in both cytoplasm and nucleus of the cell, with active nuclear transport mechanisms maintaining the cellular actin balance.
Vartiainen, Maria K., Kyheröinen, Salla, Sokolova, Maria, Hyrskyluoto, Alise   +3 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Aminopurvalanol A, a Potent, Selective, and Cell Permeable Inhibitor of Cyclins/Cdk Complexes, Causes the Reduction of in Vitro Fertilizing Ability of Boar Spermatozoa, by Negatively Affecting the Capacitation-Dependent Actin Polymerization

Frontiers in Physiology, 2017
The adoption of high-througput technologies demonstrated that in mature spermatozoa are present proteins that are thought to be not present or active in sperm cells, such as those involved in control of cell cycle.
Nicola Bernabò, Luca Valbonetti, Luana Greco, Giulia Capacchietti, Marina Ramal Sanchez, Paola Palestini, Laura Botto, Mauro Mattioli, Mauro Mattioli, Barbara Barboni   +9 more
doaj   +1 more source

C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response

Frontiers in Cell and Developmental Biology, 2022
Proline:arginine (PR) poly-dipeptides from the GGGGCC repeat expansion in C9orf72 have cytotoxicity and bind intermediate filaments (IFs). However, it remains unknown how PR poly-dipeptides affect cytoskeletal organization and focal adhesion (FA ...
Tomo Shiota, Riko Nagata, Sotaro Kikuchi, Hitoki Nanaura, Masaya Matsubayashi, Mari Nakanishi, Shinko Kobashigawa, Noriyoshi Isozumi, Takao Kiriyama, Kazuaki Nagayama, Kazuma Sugie, Yoshito Yamashiro, Eiichiro Mori, Eiichiro Mori   +13 more
doaj   +1 more source

The dynamic status of actin in the regulation of environmental sensing and homeostatic control in Saccharomyces cerevisiae [PDF]

, 2014
Actin is a highly conserved protein in eukaryotes which forms dynamic cytoskeletal structures. Rapid remodeling of actin filaments is important for the regulation of a broad range of critical cellular processes.
Smethurst, Daniel George Jan
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source