Results 51 to 60 of about 1,007,443 (313)

Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression

Frontiers in Molecular Neuroscience
Drebrin (DBN), an actin-binding protein critical for the structural integrity and function of dendritic spines, is highly phosphorylated at steady state in neurons.
Rafaela Pedro Silva, Rafaela Pedro Silva, Till G. A. Mack, Marieluise Kirchner, Philipp Mertins, Britta J. Eickholt, Patricia Kreis   +6 more
doaj   +1 more source

Viscoelastic Cell Mechanics and actin remodelling are dependent on the rate of applied pressure [PDF]

, 2012
Background: living cells are subjected to external and internal mechanical stresses. The effects of these stresses on the deformation and subsequent biological response of the cells remains unclear. This study tested the hypothesis that the rate at which
Martin M Knight, Bader, DL, Bader, Dan L., Knight, Martin M., Knight, MM, Pravincumar, Priyanka, Priyanka Pravincumar, Dan L Bader, Pravincumar, P   +8 more
core   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A new family of bacterial actin-like proteins regulates cell morphology in a filamentous cyanobacterium

mSphere
Actin proteins are common to all domains of life and exhibit ATP-dependent polymerization to form filaments. In bacteria, four families of bacterial actin-like proteins (BALPs) have been identified and characterized.
Alicia Nguyen, Garrett M. Jenkins, Peyton D. Brones, Gabriel A. Parrett, Guy M. Hagen, Jeremy M. Bono, Douglas D. Risser   +6 more
doaj   +1 more source

Ofloxacin as a Disruptor of Actin Aggresome “Hirano Bodies”: A Potential Repurposed Drug for the Treatment of Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2020
There is a growing number of aging populations that are more prone to the prevalence of neuropathological disorders. Two major diseases that show a late onset of the symptoms include Alzheimer’s disorder (AD) and Parkinson’s disorder (PD), which are ...
Samridhi Pathak, Haifa Parkar, Sarita Tripathi, Avinash Kale   +3 more
doaj   +1 more source

Age-dependent increase of cytoskeletal components in sensory axons in human skin

Frontiers in Cell and Developmental Biology, 2022
Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites.
Klara Metzner, Klara Metzner, Omar Darawsha, Mengzhe Wang, Nayana Gaur, Nayana Gaur, Yiming Cheng, Annekathrin Rödiger, Christiane Frahm, Otto W. Witte, Fabiana Perocchi, Fabiana Perocchi, Fabiana Perocchi, Hubertus Axer, Julian Grosskreutz, Julian Grosskreutz, Monika S. Brill, Monika S. Brill   +17 more
doaj   +1 more source

Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis [PDF]

, 2007
During animal cell chemotaxis, signalling at the plasma membrane induces actin polymerisation to drive forward cell movement. Since the cellular pool of actin is limited, efficient protrusion formation also requires the coordinated disassembly of pre ...
Larsen, MR, Baum, B, Waterfield, MD, Jovceva, E, Timms, JF   +4 more
core  

Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy [PDF]

, 2013
BACKGROUND: In the heart, cytoplasmic actin networks are thought to have important roles in mechanical support, myofibrillogenesis, and ion channel function.
Benz, PM, Frantz, Stefan, Merkel, CJ, Offner, Kristin, Fleming, Ingrid, Feller, Stephan M., Renné, T, Gambaryan, Stepan, Unger, A, Linke, Wolfgang A., Fischer, T, Merkel, Carla J., Bayer, B, Schuh, K, Benz, Peter M., Wagner, Helga, Ullrich, Melanie, Linke, WA, Bayer, Barbara, Ullrich, M, Offner, K, Renné, Thomas, Abeßer, M, Ursitti, Jeanine A., Frantz, S, Adham, Ibrahim M., Unger, Andreas, Adham, IM, Feller, SM, Fischer, Tobias, Wagner, H, Abeßer, Marco, Schuh, Kai, Gambaryan, S, Fleming, I, Ursitti, JA   +35 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

PXF-1 promotes synapse development at the neuromuscular junction in Caenorhabditis elegans

Frontiers in Molecular Neuroscience, 2022
Guanine nucleotide exchange factors (GEFs) are a family of proteins that modulate small G protein signaling. Mutations in a subfamily of GEFs that act on Rap, known as RapGEFs, have been associated with neurological disorders, and knockout mice display ...
Reagan Lamb, Bithika Dhar, Salvatore J. Cherra   +2 more
doaj   +1 more source