Results 71 to 80 of about 1,291,235 (309)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Aminopurvalanol A, a Potent, Selective, and Cell Permeable Inhibitor of Cyclins/Cdk Complexes, Causes the Reduction of in Vitro Fertilizing Ability of Boar Spermatozoa, by Negatively Affecting the Capacitation-Dependent Actin Polymerization

Frontiers in Physiology, 2017
The adoption of high-througput technologies demonstrated that in mature spermatozoa are present proteins that are thought to be not present or active in sperm cells, such as those involved in control of cell cycle.
Nicola Bernabò, Luca Valbonetti, Luana Greco, Giulia Capacchietti, Marina Ramal Sanchez, Paola Palestini, Laura Botto, Mauro Mattioli, Mauro Mattioli, Barbara Barboni   +9 more
doaj   +1 more source

C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response

Frontiers in Cell and Developmental Biology, 2022
Proline:arginine (PR) poly-dipeptides from the GGGGCC repeat expansion in C9orf72 have cytotoxicity and bind intermediate filaments (IFs). However, it remains unknown how PR poly-dipeptides affect cytoskeletal organization and focal adhesion (FA ...
Tomo Shiota, Riko Nagata, Sotaro Kikuchi, Hitoki Nanaura, Masaya Matsubayashi, Mari Nakanishi, Shinko Kobashigawa, Noriyoshi Isozumi, Takao Kiriyama, Kazuaki Nagayama, Kazuma Sugie, Yoshito Yamashiro, Eiichiro Mori, Eiichiro Mori   +13 more
doaj   +1 more source

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [PDF]

, 1994
The myristoylated form of c-Abl protein, as well as the P210bcr/abl protein, have been shown by indirect immunofluorescence to associate with F-actin stress fibers in fibroblasts. Analysis of deletion mutants of c-Abl stably expressed in fibroblasts maps
Baltimore, David, Jackson, Peter K., Janmey, Paul A., Matsudaira, Paul T., Sanders, Mitchell C., Van Etten, Richard A.   +5 more
core   +4 more sources

Curved Tails in Polymerization-Based Bacterial Motility

, 2001
The curved actin ``comet-tail'' of the bacterium Listeria monocytogenes is a visually striking signature of actin polymerization-based motility. Similar actin tails are associated with Shigella flexneri, spotted-fever Rickettsiae, the Vaccinia virus, and
A. Mogilner, A.L. Rozelle, A.R. Bausch, A.V. Zvelindovsky, B. Alberts, C. Kocks, C. Kocks, C.J. Merrifield, D. Pantaloni, D.E. Koppel, E. Domann, E. Gouin, E.J. Jervis, E.L. Palmer, F. Frischknecht, F. Gerbal, F. Gerbal, F. Perrin, F.C. MacKintosh, G.A. Smith, H. Berg, I. Pagonabarraga, J. Crank, J. Steinhauer, J.A. Theriot, J.A. Theriot, J.A. Theriot, J.E. Italiano, Jr., K. Kroy, K. Luby-Phelps, L. Ma, L.A. Cameron, L.G. Tilney, L.M. Machesky, L.M. Machesky, M. A. Moors,, M. Charles, M.B. Goldberg, M.B. Goldberg, M.D. Welch, M.L. Bernardini, P.D. Frymier, R. Thar,, R.A. Brundage, R.A. Heinzen, R.A. Heinzen, S. Cudmore, S. Dramsi, S.F. Hayes, T.P. Loisel, W.L. Zeile   +50 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Formation of Cytoplasmic Actin-Cofilin Rods is Triggered by Metabolic Stress and Changes in Cellular pH

Frontiers in Cell and Developmental Biology, 2021
Actin dynamics plays a crucial role in regulating essential cell functions and thereby is largely responsible to a considerable extent for cellular energy consumption.
Hellen C. Ishikawa-Ankerhold, Hellen C. Ishikawa-Ankerhold, Sophie Kurzbach, Arzu S. Kinali, Annette Müller-Taubenberger   +4 more
doaj   +1 more source

Molecular Model of the Contractile Ring

, 2005
We present a model for the actin contractile ring of adherent animal cells. The model suggests that the actin concentration within the ring and consequently the power that the ring exerts both increase during contraction.
D. Biron, D. Biron, D. Humphrey, D. H. Boal, E. Alvarez-Lacalle, E. Moses, I. Mabuchi, I. Mabuchi, J. Howard, O. Thoumine, R. Rappaport, R. L. Debiasio, T. Tlusty, T. D. Pollard, T. E. Schroeder, T. E. Schroeder   +15 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Coupling of actin hydrolysis and polymerization: Reduced description with two nucleotide states

, 2010
The polymerization of actin filaments is coupled to the hydrolysis of adenosine triphosphate (ATP), which involves both the cleavage of ATP and the release of inorganic phosphate.
Abramowitz M., Bray D., Carlier M.-F., J. Kierfeld, R. Lipowsky, Theriot J. A., X. Li   +6 more
core   +1 more source