Results 91 to 100 of about 1,019,729 (309)

Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex

eLife, 2020
T cell activation by dendritic cells (DCs) involves forces exerted by the T cell actin cytoskeleton, which are opposed by the cortical cytoskeleton of the interacting antigen-presenting cell.
Daniel Blumenthal, Vidhi Chandra, Lyndsay Avery, Janis K Burkhardt   +3 more
doaj   +1 more source

Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation. [PDF]

, 2012
Primary cilia are cellular appendages important for signal transduction and sensing the environment. Bardet-Biedl syndrome proteins form a complex that is important for several cytoskeleton-related processes such as ciliogenesis, cell migration and ...
D Jenkins, PL Beales, Knight, M, Helen May-Simera, Dagan Jenkins, Anna Diaz-Font, Philip L. Beales, Beales, PL, H May-Simera, Diaz-Font, A, Pravincumar, P, A Diaz-Font, Hernandez-Hernandez, V, May-Simera, H, V Hernandez, P Pravincumar, Victor Hernandez-Hernandez, Priyanka Pravincumar, Jenkins, D, M Knight, Martin Knight   +20 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Actin at cell-cell junctions is composed of two dynamic and functional populations [PDF]

, 2005
The ability of epithelial cells to polarize requires cell-cell adhesion mediated by cadherin receptors. During cell-cell contact, the mechanism via which a flat, spread cell shape is changed into a tall, cuboidal epithelial morphology is not known.
Erasmus, J., Zeikos, K., Braga, V.M.M., Betson, M., Bailly, M., Cramer, L.P., Zhang, J.   +6 more
core  

Modulation of the Actin Cytoskeleton via Gelsolin Regulates Vacuolar H+-ATPase Recycling [PDF]

, 2004
The role of the actin cytoskeleton in regulating membrane protein trafficking is complex and depends on the cell type and protein being examined. Using the epididymis as a model system in which luminal acidification is crucial for sperm maturation and ...
Pastor-Soler, Nuria, Breton, Sylvie, Brown, Christopher R., Brown, Dennis, Smith, Peter J. S., Beaulieu, Valerie, Smith, Peter J.S., Da Silva, Nicolas, Brenton, Sylvie   +8 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Single-molecule turnover dynamics of actin and membrane coat proteins in clathrin-mediated endocytosis

eLife, 2019
Actin dynamics generate forces to deform the membrane and overcome the cell’s high turgor pressure during clathrin-mediated endocytosis (CME) in yeast, but precise molecular details are still unresolved. Our previous models predicted that actin filaments
Michael M Lacy, David Baddeley, Julien Berro   +2 more
doaj   +1 more source

Actin

1We present the concept of actin networks, which serve as intracellularframeworks, actuator systems, and pathways for information transferand processing within ...
Tuszyński, Jack, Adamatzky, Andrew, Schnauß, Jörg   +2 more
core   +1 more source

Local measurements of viscoelastic moduli of entangled actin networks using an oscillating magnetic bead micro-rheometer [PDF]

, 1994
A magnetically driven bead micro-rheometer for local quantitative measurements of the viscoelastic moduli in soft macromolecular networks such as an entangled F-actin solution is described.
Sackmann, E., F. Ziemann, J. Radler, E. Sackmann, Ziemann, F., Rädler, Joachim O.   +5 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source