Results 91 to 100 of about 1,007,443 (313)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex
eLife, 2020 T cell activation by dendritic cells (DCs) involves forces exerted by the T cell actin cytoskeleton, which are opposed by the cortical cytoskeleton of the interacting antigen-presenting cell.
Daniel Blumenthal +3 more
doaj +1 more source
Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments [PDF]
, 1999 The influenza virus genome is transcribed in the nuclei of infected cells but assembled into progeny virions in the cytoplasm. This is reflected in the cellular distribution of the virus nucleoprotein (NP), a protein which encapsidates genomic RNA to ...
Pope, Brian +5 more
core
, 2023 20-time points of structured illumination microscopy F-actin data
XiaoDong Tang (15310825)
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Concerted upregulation of CLP36 and smooth muscle actin protein expression in human endometrium during decidualization [PDF]
, 2005 The human endometrium prepares for implantation of the blastocyst by reorganization of its whole cellular network. Endometrial stroma cells change their phenotype starting around the 23rd day of the menstrual cycle.
Neumaier-Wagner, Peruka +7 more
core +1 more source
, 2023 20-time points of structured illumination microscopy F-actin data
XiaoDong Tang (15310825)
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
eLife, 2019 Actin dynamics generate forces to deform the membrane and overcome the cell’s high turgor pressure during clathrin-mediated endocytosis (CME) in yeast, but precise molecular details are still unresolved. Our previous models predicted that actin filaments
Michael M Lacy +2 more
doaj +1 more source
Nucleoskeletal regulation of transcription : Actin on MRTF [PDF]
, 2019 Myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF) form an essential transcriptional complex that regulates the expression of many cytoskeletal genes in response to dynamic changes in the actin cytoskeleton.
Vartiainen, Maria K. +1 more
core +1 more source