Results 251 to 260 of about 1,007,443 (313)

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn   +20 more
wiley   +1 more source

BetaII-spectrin gaps and patches emerge from the patterned assembly of the actin/spectrin membrane skeleton in human motor neuron axons. [PDF]

open access: yesElife
Gazal NG   +14 more
europepmc   +1 more source

Mechanism of actin thin filament pointed-end elongation by leiomodin. [PDF]

open access: yesNat Commun
Brotzman SB   +3 more
europepmc   +1 more source

Leiomodin 2 is a processive pointed-end elongator of actin filaments. [PDF]

open access: yesNat Commun
Biswas S   +4 more
europepmc   +1 more source

HSV-1 US3 Hijacks Conserved Actin Regulatory Complexes to Drive F-Actin Remodeling. [PDF]

open access: yesViruses
Hossain MI   +9 more
europepmc   +1 more source
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Plasmodium motility: actin not actin' like actin

Trends in Parasitology, 2006
Apicomplexan parasites such as Plasmodium and Toxoplasma display actomyosin-dependent motility in the absence of readily detectable actin polymers. Three recent studies indicate that parasite actin polymers, either harvested from parasites or formed from purified recombinant proteins, are exceptionally short ( approximately 100 nm).
Herwig, Schüler, Kai, Matuschewski
openaire   +2 more sources

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