Results 171 to 180 of about 287,702 (305)
Advanced Science, EarlyView.In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang +10 more
wiley +1 more source
Levamisole Modulation of Podocytes' Actin Cytoskeleton in Nephrotic Syndrome. [PDF]
Biomedicines, 2023 Veissi ST +11 more
europepmc +1 more source
The septin cytoskeleton facilitates membrane retraction during motility and blebbing. [PDF]
, 2012 Increasing evidence supports a critical role for the septin cytoskeleton at the plasma membrane during physiological processes including motility, formation of dendritic spines or cilia, and phagocytosis.
Chen, Yi-Chun M +3 more
core
Advanced Science, EarlyView.Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li +12 more
wiley +1 more source
Thrombocytopenia: A Defect in Actin Dynamics?
European Medical Journal Hematology, 2017 The actin cytoskeleton plays many important roles in the lifecycle of platelets, from biogenesis from megakaryocytes, to activation and clearance from the circulation.
Ariane S. I. Standing
doaj
Cartilage Differentiation and the Actin Cytoskeleton
, 2016 Chondrogenesis, e.g., the formation of cartilage from precursor cells, is characterized by drastic changes in cell shape and size. This involves major reorganization of the cytoskeleton, in particular the actin network. However, we have known for several decades that the actin cytoskeleton does not merely and passively respond to upstream signals but ...
openaire +4 more sources
A T-lymphoma transmembrane glycoprotein (gp180) is linked to the cytoskeletal protein, fodrin. [PDF]
, 1985 A major mouse T-lymphoma surface glycoprotein (gp180) has been identified by labeling cells with 125I and [3H]glucosamine. After ligand-induced receptor patching and/or capping, the amount of gp 180 in the membrane-associated cytoskeleton fraction ...
Bourguignon, LY +3 more
core
Advanced Science, EarlyView.MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun +13 more
wiley +1 more source
Confined Migration Drives Stem Cell Differentiation
Advanced Science, EarlyView.Human mesenchymal stem cell (hMSC) homing to sites of regeneration requires navigation through mechanically confining extracellular matrix environments, inducing rapid and dramatic morphological adaptation. By exposing hMSCs to specific levels of physiological confinement, it is demonstrated that confinement can induce osteogenesis, and that this fate ...
Xu Gao +6 more
wiley +1 more source
Advanced Science, EarlyView.The salivary sheath protein myosin from SBPH is critical for the formation of the salivary sheath and feeding. However, myosin functions as a HAMP and triggered plant BAK1‐mediated PTI responses, which include the activation of calcium signaling pathways, MAPK phosphorylation, ROS bursts, and cell death, thereby triggering JA pathway.
Liangxuan Qi +12 more
wiley +1 more source