Results 281 to 290 of about 316,202 (350)

Calponin 3 Regulates Myoblast Proliferation and Differentiation Through Actin Cytoskeleton Remodeling and YAP1-Mediated Signaling in Myoblasts. [PDF]

Cells
Nguyen MT, Ly QK, Ngo THP, Lee W.
europepmc   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

The Actin Cytoskeleton as a Regulator of Proteoglycan 4. [PDF]

Cartilage
Gonzalez-Nolde S, Schweiger CJ, Davis EER, Manzoni TJ, Hussein SMI, Schmidt TA, Cone SG, Jay GD, Parreno J.   +8 more
europepmc   +1 more source

Rod‐Shaped Nanotherapeutics Alleviate Rheumatoid Arthritis by Precisely Disrupting Platelet‐Mediated Pathological Crosstalk via a Morphology‐Dependent Manner

Advanced Science, EarlyView.
Owing to the margination effect, rod‐shaped nanoparticles exhibit markedly enhanced co‐localization with endothelial‐adherent platelets (PLTs) under dynamic blood flow. When internalized by PLTs, rod‐shaped PNR@Res inhibit FAK and PI3K/AKT signaling in a morphology‐dependent manner, thereby disrupting their pathological crosstalk with various ...
Bin Zhang, Yuanyi Hua, Xin Wen, Zhumei Liao, Jianheng Ren, Yajun Weng, Qin Wang   +6 more
wiley   +1 more source

Diffusion model predicts the geometry of actin cytoskeleton from cell morphology. [PDF]

PLoS Comput Biol
Li H, Liu S, Deguchi S, Matsunaga D.
europepmc   +1 more source

Mechanical Stimuli‐Induced Manipulation of Malignant Behavior in Bioprinted Cancer Microtissues via PI3K/NF‐κB Activation

Advanced Science, EarlyView.
A mechanically tunable ECM platform is created by integrating dECM–alginate matrices with in‐bath tumor printing. The mechanically tunable ECM environment drives tumors to acquire hypoxia, mechanotransduction signaling, metastatic traits, and drug‐resistant phenotypes that collectively promote malignant transformation.
Seok‐Hyeon Lee, Jeongho Lee, Min‐Seo Choi, Minjun Ahn, Sik Yoon, Dongjun Lee, Sae‐Ock Oh, Won‐Woo Cho, Byoung Soo Kim   +8 more
wiley   +1 more source

PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators. [PDF]

Nucleic Acids Res
Wang Y, Chembazhi UV, Yee D, Chen S, Ji J, Wang Y, Nguyen KL, Lin P, Ratti A, Hess RA, Qiao H, Ko C, Yang J, Kalsotra A, Mei W.   +14 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

THE ACTIN CYTOSKELETON CONTROLS NADPH OXIDASE ACTIVATION AND G PROTEIN RECRUITMENT MEDIATED BY NEUTROPHIL Gαq-COUPLED RECEPTORS

Levin NK, Dahlgren C, Forsman H, Sundqvist M.   +3 more
europepmc   +1 more source

The Ca²⁺-actin-cytoskeleton axis in podocytes is an important, non-immunologic target of immunosuppressive therapy in proteinuric kidney diseases. [PDF]

Pediatr Nephrol
Hackl A, Weber LT.
europepmc   +1 more source