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The Leukocyte Actin Cytoskeleton
Bulletin de l'Institut Pasteur, 1996The main task of leukocytes is to patrol throughout the body in order to detect and eliminate potentially harmful structures such as invading microorganisms or effete cells. The fulfilment of these functions often requires that cells undergo drastic morphological changes. These changes may be passive, e.g.
Fabienne Richelme +2 more
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Integrins and the actin cytoskeleton
Current Opinion in Cell Biology, 2007The ability to connect to the actin cytoskeleton is a key part of the adhesive function of integrins. This linkage between integrins and the cytoskeleton involves a large complex of integrin-associated proteins that function in both the assembly and disassembly of the link.
Nicholas H. Brown, Isabelle Delon
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Viral manipulations of the actin cytoskeleton [PDF]
Trends in Microbiology, 1997 Viruses succeed as intracellular parasites because of their ability to invade cells and appropriate the cellular machinery required during their life cycle. The actin cytoskeleton of the host cell does not escape viral infection unscathed, but is often co-opted by the virus at many different stages of its life cycle to facilitate the infection process.
Sally Cudmore +2 more
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INTRACELLULAR PATHOGENS AND THE ACTIN CYTOSKELETON
Annual Review of Cell and Developmental Biology, 1998▪ Abstract Many pathogens actively exploit the actin cytoskeleton during infection. This exploitation may take place during entry into mammalian cells after engagement of a receptor and/or as series of signaling events culminating in the engulfment of the microorganism. Although actin rearrangements are a common feature of most internalization events
Dramsi, S., Cossart, P.
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Biomimetic Models of the Actin Cytoskeleton
Small, 2007AbstractThe cytoskeleton is a complex polymer network that plays an essential role in the functionality of eukaryotic cells. It endows cells with mechanical stability, adaptability, and motility. To identify and understand the mechanisms underlying this large variety of capabilities and to possibly transfer them to engineered networks makes it ...
Mireille M. A. E. Claessens +14 more
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Medical aspects of the actin cytoskeleton
Current Opinion in Cell Biology, 1995The actin cytoskeleton is affected in many disease states. The mechanisms by which altered structure or expression of actin or of actin-binding proteins cause specific defects are beginning to emerge. Notable recent findings concern the roles in tumor suppression of proteins that link actin to the cell membrane, the specific functions of actin isoforms
Janmey, P. A., Chaponnier, Christine
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Evidence of Actin in the Cytoskeleton of Microsporidia
Journal of Eukaryotic Microbiology, 1999Using transmission electron microscopy, fluorescence microscopy, immuno‐electron microscopy, and biochemical techniques such as 2‐D electrophoresis and immunoblotting, actin was found in all biological stages of the microsporidia Encephalitozoon hellem and Encephalitozoon cuniculi.
BIGLIARDI, ELISA +9 more
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Prokaryotic origin of the actin cytoskeleton [PDF]
Nature, 2001 It was thought until recently that bacteria lack the actin or tubulin filament networks that organize eukaryotic cytoplasm. However, we show here that the bacterial MreB protein assembles into filaments with a subunit repeat similar to that of F-actin-the physiological polymer of eukaryotic actin.
Fusinita van den Ent +2 more
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Apoptosis and the yeast actin cytoskeleton [PDF]
Cell Death & Differentiation, 2009 Actin represents one of the most abundant and extensively studied proteins found in eukaryotic cells. It has been identified as a major target for destruction during the process of apoptosis. Recent research has also highlighted a role for cytoskeletal components in the initiation and inhibition of apoptotic processes.
Vassilios N. Kotiadis +3 more
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Functional design in the actin cytoskeleton
Current Opinion in Cell Biology, 1999Changes in cell shape, anchorage and motility are all associated with the dynamic reorganisation of the architectural arrays of actin filaments that make up the actin cytoskeleton. The relative expression of these functionally different actin filament arrays is intimately linked to the pattern of contacts that a cell develops with its extracellular ...
J. Victor Small +2 more
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