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Fabrication Routes for Ionic Conducting Fiber Strain Sensors
Ionic conducting fiber strain sensors (ICFSs) offer compliant, textile‐integrable sensing. Thus far, the commercialization of ICFSs has been constrained by fiber fabrication routes. This review provides a fabrication‐centric analysis of ICFSs correlating processing strategies with material properties and scalability.
Leo John Kershaw +3 more
wiley +1 more source
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NorthStar Perspectives for Actinium-225 Production at Commercial Scale
Current Radiopharmaceuticals, 2018Actinium-225, and its daughter Bismuth-213, have great promise in Alpha Immuno Therapy (AIT) for treatment of various disease modalities. Unfortunately, current production levels of actinium-225 do not support broad use of either actinium-225 or bismuth-213 in development or use for disease treatment.
exaly +3 more sources
Liposomal Actinium-225 as a potential cancer therapeutic
Alpha-particle emitting radionuclides are a promising class of emitters for the treatment of cancer. Emitted alpha-particles deposit considerable energy along a short-ranged trajectory (<100 µm), allowing the potential for highly localized and cytotoxic irradiation of cancer while sparing the surrounding healthy tissues from off-target effects.
openaire +2 more sources
Challenges and opportunities in developing Actinium-225 radiopharmaceuticals
Nuclear Medicine Communications, 2022Actinium-225 (225Ac) has emerged as a promising therapeutic radioisotope for targeted alpha therapy. It emits net four alpha particles during its decay to stable daughter bismuth-209, rightly called an in-vivo nano-generator. Compared to the worldwide demand of 225Ac, the amount produced via depleted thorium-229 sources is minimal, making it an ...
Deeksha, Dhiman +2 more
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Alpha particle-emitting isotopes have been proposed as novel cytotoxic agents for augmenting targeted therapy. Properties of alpha particle radiation such as their limited range in tissue of a few cell diameters and their high linear energy transfer ...
Matthias Miederer +2 more
exaly +2 more sources
Journal of Radioanalytical and Nuclear Chemistry Articles, 1996
Dependence upon pH of Ac and Th distribution coefficients between the cation exchange resin and buffer citrate solutions had been investigated; the optimal conditions are suggested for effective separation of the elements in this system. These results are in successful accordance with such conditions calculated on the basement of Ac and Th citrate ...
V. Tsoupko-Sitnikov +2 more
openaire +1 more source
Dependence upon pH of Ac and Th distribution coefficients between the cation exchange resin and buffer citrate solutions had been investigated; the optimal conditions are suggested for effective separation of the elements in this system. These results are in successful accordance with such conditions calculated on the basement of Ac and Th citrate ...
V. Tsoupko-Sitnikov +2 more
openaire +1 more source
Isolation of actinium-225 for medical purposes
Radiochemistry, 2015A procedure is described for isolation and purification of 225Ac as a 229Th daughter decay product using ion exchange. The process includes the following steps: separation of 229Th from a mixture of 225Ac and 225Ra (225Ac precursor) using an anion-exchange resin; separation of 225Ac and 225Ra using a cation-exchange resin; purification of 225Ac to ...
A. A. Kotovskii +6 more
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Improved in Vivo Stability of Actinium-225 Macrocyclic Complexes
Journal of Medicinal Chemistry, 1999The favorable nuclear properties of actinium-225 ((225)Ac) have led to proposal of this isotope for use in radioimmunotherapy. In an effort to reduce the toxicity of free (225)Ac, a series of ligands were evaluated for stability in vivo. Loss of (225)Ac from acyclic chelating agents resulted in high liver uptake and poor whole body clearance.
K A, Deal +4 more
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Production of actinium-225 for alpha particle mediated radioimmunotherapy
Applied Radiation and Isotopes, 2005The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent.
Rose A, Boll +2 more
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Computer-Assisted Design of Macrocyclic Chelators for Actinium-225 Radiotherapeutics
Inorganic Chemistry, 2020Actinium-225 (225Ac) is an excellent candidate for targeted radiotherapeutic applications for treating cancer, because of its 10-day half-life and emission of four high-energy α2+ particles. To harness and direct the energetic potential of actinium, strongly binding chelators that remain stable in vivo during biological targeting must be developed ...
Amanda Morgenstern +5 more
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