Results 71 to 80 of about 1,392 (217)

TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6–GAS6 Axis

open access: yesAdvanced Science, EarlyView.
This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu   +8 more
wiley   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

open access: yesAdvanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi   +4 more
wiley   +1 more source

[225Ac]Ac-labeled matuzumab is an effective radioimmunotherapeutic against EGFR-positive triple negative breast cancer

open access: yesBreast Cancer Research
Background EGFR is overexpressed in TNBC, and “naked” anti-EGFR monoclonal antibodies have been evaluated in clinical trials with dismal effectiveness. Matuzumab is an anti-EGFR monoclonal antibody that can be used to develop theranostics.
Anjong Florence Tikum   +9 more
doaj   +1 more source

Review: Insight on Porous Carbon Positive Electrode for Sodium‐Ion Capacitors: Interplay Between Synthesis, Properties, and Performance

open access: yesAdvanced Science, EarlyView.
Sodium ion capacitor (SIC) is currently constrained by the low discharge capacity of commercial activated carbon as positive electrode material. This review provides a holistic summary of research efforts on alternative porous carbon materials for SIC. Image created by the authors with www.biorender.com.
Ademola Adeniji   +2 more
wiley   +1 more source

Design of a Thorium Metal Target for 225Ac Production at TRIUMF

open access: yesInstruments, 2019
With recent impressive clinical results of targeted alpha therapy using 225Ac, significant effort has been directed towards providing a reliable and sufficient supply of 225Ac to enable widespread using of 225Ac-radiopharmaceuticals.
Andrew K.H. Robertson   +4 more
doaj   +1 more source

Tuning Li+ and Na+ Functionality in Renewable Carbon Electroactive Material Through Site‐Specific Nanostructural Disorder

open access: yesAdvanced Science, EarlyView.
This study presents a selective thermal transformation of polycarbonate into hybrid carbon materials. The structured carbon enhances electrochemical performance, particularly in lithium‐ion systems. Investigations reveal improved bimetallic ion diffusivity through the hybrid microstructure, contributing to excellent charge kinetics.
Montajar Sarkar   +7 more
wiley   +1 more source

Photonuclear Population of 229m,gTh in Th‐Doped Crystals Toward Nuclear Clock Development

open access: yesAdvanced Science, EarlyView.
This study demonstrates a novel photonuclear approach for producing the nuclear clock isomer 229mTh in thorium‐doped crystals, overcoming current supply limitations. Through cross‐section calculations and Monte Carlo simulations, we identify optimal crystal materials and irradiation conditions, achieving high signal‐to‐noise ratios.
Hao‐Yang Lan   +9 more
wiley   +1 more source

Steering the Shape‐shifting of Bullvalene‐PdII Complexes Through Steric and Geometric Strain

open access: yesAngewandte Chemie, EarlyView.
This study explores the use of bis‐pyridyl substituted bullvalenes as dynamic shape‐shifting ligands within cis‐capped PdII complexes. The ring position of the pyridyl nitrogen is critical, leading to a range of Pd2L2 metallacycles and simple PdL complexes, each with distinctive bullvalene isomer preferences (represented in the figure by A‐D isomer ...
André P. Birvé   +2 more
wiley   +2 more sources

Synergistic Intra‐ and Inter‐Nanozyme Electron Transfer through Interfacial Assembly for Enhanced Multi‐Enzyme Activity

open access: yesAdvanced Science, EarlyView.
A novel Prussian blue‐based composite nanoenzymes (PB C‐NZs)‐MoS2/PB, was designed based on the electron transfer mechanism and transport pathway. The structure uses MoS2 as the substrate, with PB grown on its surface through a surface assembly method.
Kun Lu   +7 more
wiley   +1 more source

Hematological toxicity of [225Ac]Ac-PSMA-617 and [177Lu]Lu-PSMA-617 in RM1-PGLS syngeneic mouse model

open access: yesEJNMMI Radiopharmacy and Chemistry
Background Prostate cancer (PC) has a 34% 5-year survival rate after progressing to metastatic castration-resistant prostate cancer (mCRPC), which occurs in 20–30% of cases.
Meryl Maria Vilangattil   +6 more
doaj   +1 more source

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